公开(公告)号：US20240316129A1

公开(公告)日：2024-09-26

申请号：US18570867

申请日：2022-06-16

申请人： The UAB Research Foundation ,  RESBIOTIC NUTRITION, INC.

发明人： Charitharth Vivek LAL ,  Nancy Wenger

IPC分类号： A61K35/747 ,  A61K9/00 ,  A61K36/19 ,  A61K36/53 ,  A61K36/9066

CPC分类号： A61K35/747 ,  A61K9/0053 ,  A61K36/19 ,  A61K36/53 ,  A61K36/9066

摘要： A combination of herbal extracts and a probiotic supplement and formulated as a dietary supplement helps mitigate symptoms of bronchopulmonary disease in conjunction with the anti-inflammatory mechanisms of the probiotics. Provided are embodiments of a probiotic nutraceutical composition that delivers 3 strains of Lactobacillus spp. to the gut lining of human subjects to reduce neutrophilic inflammation as a result of or causative agent of bronchopulmonary disease. In addition to the three Lactobacillus spp. strains, the compositions can include herbal extracts from holy basil, turmeric, and vasaka for respiratory relief.

公开(公告)号：US20240298974A1

公开(公告)日：2024-09-12

申请号：US18430270

申请日：2024-02-01

申请人： THE UAB RESEARCH FOUNDATION ,  The Board of Regents of the University of Texas System

发明人： Adeel Ilyas ,  Sandipan Bankim Behari Pati

IPC分类号： A61B5/00 ,  A61B5/293 ,  A61B5/374 ,  G16H10/60 ,  G16H50/70

CPC分类号： A61B5/7275 ,  A61B5/374 ,  A61B5/4094 ,  A61B5/7257 ,  A61B5/7267 ,  A61B5/746 ,  G16H10/60 ,  G16H50/70 ,  A61B5/293

摘要： The present disclosure describes various embodiments of systems, apparatuses, and methods for predicting an onset of a seizure by identifying a pro-octal state in advance of the seizure, potentially hours prior to seizure onset. One such method comprise acquiring, by a computing device, electroencephalography (EEG)-based features from brain activity electrical recordings of an individual; inputting, by the computing device, the EEG-based features into a deep neural network-based classifier; classifying, by the computing device using the deep neural network-based classifier, the EEG-based features to a real-valued principal dimension; and/or based on a value of the real-valued principal dimension, generating, by the computing device, a prediction of a seizure onset pro-ictal event.

公开(公告)号：US20240270828A1

公开(公告)日：2024-08-15

申请号：US18688935

申请日：2022-09-06

申请人： THE UAB RESEARCH FOUNDATION ,  TEXAS BIOMEDICAL RESEARCH INSTITUTE

发明人： James KOBIE ,  Michael PIEPENBRINK ,  Paul GOEPFERT ,  Mark R. WALTER ,  Nathan ERDMANN ,  Ashlesha DESHPANDE ,  Luis MARTINEZ-SOBRIDO ,  Jun-Gyu PARK

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61P31/14

CPC分类号： C07K16/1003 ,  A61P31/14 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure is based, at least in part, on certain human monoclonal antibodies, or antigen binding fragments thereof, having unexpected broad neutralizing activities against SARS-CoV-2. The disclosed antibodies and/or antigen-binding fragments thereof are therapeutic agents for the treatment of SARS-CoV-2 infections and are suitable for use in therapeutic methods to protect individuals from SARS-CoV-2 infections.

公开(公告)号：US20240174721A1

公开(公告)日：2024-05-30

申请号：US18516332

申请日：2023-11-21

申请人： THE UAB RESEARCH FOUNDATION

发明人： Michael Niederweis ,  Mikhail Pavlenok

IPC分类号： C07K14/35 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

CPC分类号： C07K14/35 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N27/44756 ,  G01N33/48721

摘要： Provided herein are mutant single-chain Mycobacterium smegmatis porin (Msp) and uses thereof.

公开(公告)号：US20240124928A1

公开(公告)日：2024-04-18

申请号：US18305770

申请日：2023-04-24

申请人： University of Washington ,  The UAB Research Foundation

发明人： Jens H. Gundlach ,  Michael Niederweis ,  Thomas Z. Butler ,  Mikhail Pavlenok ,  Mark A. Troll ,  Suja Sukumaran

IPC分类号： C12Q1/6869 ,  A61K39/04 ,  C07K14/35 ,  C12N13/00 ,  G01N27/447 ,  G01N33/487 ,  G01N33/68

CPC分类号： C12Q1/6869 ,  A61K39/04 ,  C07K14/35 ,  C12N13/00 ,  G01N27/44704 ,  G01N27/44791 ,  G01N33/48721 ,  G01N33/6872 ,  A61K39/00

摘要： Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

公开(公告)号：US11945857B2

公开(公告)日：2024-04-02

申请号：US17126396

申请日：2020-12-18

申请人： THE UAB RESEARCH FOUNDATION

发明人： Max D. Cooper ,  Brantley R. Herrin ,  Matthew N. Alder

IPC分类号： C07K16/12 ,  C07K16/10 ,  C07K16/34

CPC分类号： C07K16/1278 ,  C07K16/1018 ,  C07K16/1063 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/76

摘要： Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.

公开(公告)号：US20230414309A1

公开(公告)日：2023-12-28

申请号：US18265080

申请日：2021-12-07

申请人： THE UAB RESEARCH FOUNDATION

发明人： Kyle Wood ,  Andres Morales ,  Sean Simmons

IPC分类号： A61B50/26 ,  A61G13/10

CPC分类号： A61B50/26 ,  A61G13/101

摘要： A surgical tool support system is provided. The system includes a support portion, a swivel arm, and a tool holder for holding a surgical tool coupled to a distal end of the swivel arm. The tool holder can have a locking joint controlled by an actuator such that the tool holder can be locked into a position along multiple axes of rotation. The system can offset the force required by a user to move the surgical tool, thereby reducing fatigue.

公开(公告)号：US11767346B2

公开(公告)日：2023-09-26

申请号：US17689324

申请日：2022-03-08

申请人： University of Florida Research Foundation, Incorporated ,  The UAB Research Foundation

发明人： Sergei Zolotukhin ,  Sanford L. Boye ,  Shannon E. Boye ,  Damien Marsic ,  Paul D. Gamlin

IPC分类号： C07K14/005 ,  C12N15/10 ,  C12N15/86 ,  C12N7/00

CPC分类号： C07K14/005 ,  C12N15/1037 ,  C12N15/86 ,  C12N7/00 ,  C12N2320/32 ,  C12N2750/14011 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

摘要： Adeno associated viral (AAV) particles are emerging as a useful vehicle for gene delivery to various organs and tissues, one of them being the retina. Provided here are variant AAV (for example, variant serotype 2 (AAV2)) capsid proteins and variant capsid protein containing particles with enhanced ability to transduce retinal cells.

公开(公告)号：US11753374B2

公开(公告)日：2023-09-12

申请号：US17529199

申请日：2021-11-17

申请人： Southern Research Institute ,  UAB Research Foundation

发明人： Mark J. Suto ,  Bini Mathew ,  Anupam Agarwal ,  Amie M. Traylor

IPC分类号： C07D207/416 ,  C07D405/04 ,  C07D417/10

CPC分类号： C07D207/416 ,  C07D405/04 ,  C07D417/10

摘要： The present disclosure is concerned with biaryl aminomaleimide compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230263826A1

公开(公告)日：2023-08-24

申请号：US17891020

申请日：2022-08-18

申请人： The UAB Research Foundation

发明人： Sasanka Ramanadham ,  Hanil Kumar Challa

IPC分类号： A61K35/17 ,  A61P3/08

CPC分类号： A61K35/17 ,  A61P3/08

摘要： The invention relates to cells for adoptive cell therapy, e.g., adoptive immunotherapy. The cells include macrophages in which the iPLA2β gene is disrupted. Also provided are methods and uses of the cells, such as in adoptive therapy in the treatment or prevention of type 1 diabetes (T1D). Also provided are methods for engineering, preparing, and producing the cells, and compositions containing the cells. In some aspects, the provided embodiments provide an improved composition and method for the treatment of T1D. Among the cells disclosed herein are those in which certain genes and/or gene products have been disrupted, modified and/or repressed, in particular via disruption that impairs or reduces expression of iPLA2β.