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公开(公告)号：US10004719B1
公开(公告)日：2018-06-26
申请号：US15607825
申请日：2017-05-30
IPC分类号： C07D473/00 , C07D473/34 , C07D471/04 , A61K31/407 , A61K31/79 , A61K31/795 , A61K31/765 , A61K31/4015 , A61K31/41 , A61K9/14 , A61K9/20
CPC分类号： A61K31/407 , A61K9/1635 , A61K9/1641 , A61K9/2054 , A61K9/4866 , A61K31/4015 , A61K31/41 , A61K31/765 , A61K31/79 , A61K31/795 , A61K2300/00
摘要： A spray-dried solid dispersion containing a pharmaceutical compound of formula (I) shown below and a pharmaceutically acceptable polymer, in which the pharmaceutical compound is dispersed in a polymer matrix formed from the pharmaceutically acceptable polymer. Further disclosed are methods for preparing such a solid dispersion and using it for treating hepatitis C virus infection and a pharmaceutical formulation containing same.
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公开(公告)号：US20120157492A1
公开(公告)日：2012-06-21
申请号：US12500952
申请日：2009-07-10
申请人： Ming-Chu Hsu , Chi-Hsin Richard King , Judy Yuan , Wen-Chang Chen , Shan-Yen Chou , Bo Shi
发明人： Ming-Chu Hsu , Chi-Hsin Richard King , Judy Yuan , Wen-Chang Chen , Shan-Yen Chou , Bo Shi
IPC分类号： A61K31/4709 , A61P31/00 , A61P31/04 , C07D401/10
CPC分类号： C07D401/04
摘要： This invention relates to a malic acid salt of (3S,5R)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid. Also disclosed is a method of treating bacterial infection by an effective amount of this salt.
摘要翻译： 本发明涉及（3S，5R）-7- [3-氨基-5-甲基 - 哌啶基] -1-环丙基-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸的苹果酸盐 酸。 还公开了通过有效量的该盐治疗细菌感染的方法。
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公开(公告)号：US20100152452A1
公开(公告)日：2010-06-17
申请号：US12636956
申请日：2009-12-14
IPC分类号： C07D215/56 , C07C229/24 , C07D211/72 , C07C255/04 , C07C233/04
CPC分类号： C07D211/72 , C07B2200/07 , C07C223/02 , C07C233/31 , C07C255/30 , C07C271/18 , C07C271/22 , C07C271/50 , C07D215/56
摘要： This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
摘要翻译： 本发明涉及二醛或二腈化合物，其可用于哌啶，吡咯烷和氮杂环庚烷衍生物的立体选择性合成。
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4.发明授权Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases 有权抑制冠状病毒3CL和黄病毒科病毒蛋白酶的肽样化合物公开(公告)号：US07462594B2
公开(公告)日：2008-12-09
申请号：US11067264
申请日：2005-02-25
申请人： Syaulan Yang , Jen-Dar Wu , Feng-Yih Su , Chun-Wei Kuo , Wen-Chang Chen , Ming-Chu Hsu , Yibin Xiang , Ching-Cheng Wang , Shao-Ying Liao
发明人： Syaulan Yang , Jen-Dar Wu , Feng-Yih Su , Chun-Wei Kuo , Wen-Chang Chen , Ming-Chu Hsu , Yibin Xiang , Ching-Cheng Wang , Shao-Ying Liao
CPC分类号： A61K31/4015 , A61K31/675 , A61K38/04 , C07D207/26 , C07D405/06
摘要： This invention relates to treating an infection with a virus using protease inhibitors. Examples of the protease inhibitors include compounds of formula (II). Each variable is defined in the specification.
摘要翻译： 本发明涉及使用蛋白酶抑制剂治疗病毒感染。 蛋白酶抑制剂的实例包括式（II）的化合物。 每个变量在规范中定义。
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公开(公告)号：US20230012560A1
公开(公告)日：2023-01-19
申请号：US17753515
申请日：2020-09-04
发明人： Chih-Ming Chen , Chu-Chung Lin , Chang-Pin Huang , Chiayn Chiang
IPC分类号： C07D207/36 , C07D401/12 , C07D403/12 , C07D405/14
摘要： A compound of Formula (I) below, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof: (I), in which Ra, Rb, Rc, Rd, X1, X2, R1-R4, W, Z, and L are defined as in the SUMMARY section. Further disclosed are a method of using the above-described compound, salt, stereoisomer, solvate, or prodrug for treating HBV infection and a pharmaceutical composition containing same.
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公开(公告)号：US08211909B2
公开(公告)日：2012-07-03
申请号：US12206060
申请日：2008-09-08
申请人： Ming-Chu Hsu , Chi-Hsin Richard King , Shu-Jen Chen , Luke Lin
发明人： Ming-Chu Hsu , Chi-Hsin Richard King , Shu-Jen Chen , Luke Lin
IPC分类号： A61K31/47
CPC分类号： A61K31/4709
摘要： This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:
摘要翻译： 本发明涉及一种通过向有需要的受试者施用有效量的化合物的方法来治疗甲氧西林非感染性细菌，万古霉素 - 非感染性细菌，青霉素 - 非吸收性细菌，克拉霉素 - 非吸收性细菌或甲硝唑 - 非吸收性细菌的感染， 以下公式：
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公开(公告)号：US20090111757A1
公开(公告)日：2009-04-30
申请号：US12254439
申请日：2008-10-20
申请人： Chu-Chung Lin , Kuang-Yuan Lee , Chen-Fu Liu , Pin Lo , Yo-Chin Liu , Yueh-chiang Han , Chi-Hsin Richard King
发明人： Chu-Chung Lin , Kuang-Yuan Lee , Chen-Fu Liu , Pin Lo , Yo-Chin Liu , Yueh-chiang Han , Chi-Hsin Richard King
CPC分类号： C07K5/0808
摘要： Compounds of formula (I): in which R1, R2, R3 R4, and R5, U, X, Y, and Z are as defined herein. Also disclosed is use of these compounds, alone or in combination with other active agents, to treat hepatitis C virus infection.
摘要翻译： 式（I）化合物：其中R 1，R 2，R 3，R 4和R 5，U，X，Y和Z如本文所定义。 还公开了这些化合物单独或与其它活性剂组合用于治疗丙型肝炎病毒感染的用途。
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公开(公告)号：US20080292626A1
公开(公告)日：2008-11-27
申请号：US12125094
申请日：2008-05-22
申请人： Ching-Cheng Wang , Hung-Chuan Chen , Shu-Huei Wang , Mei-Chun Lin , Tien-Lan Shieh , Ying-Huey Huang , Shih-Chieh Chuang , Chi-Hsin Richard King
发明人： Ching-Cheng Wang , Hung-Chuan Chen , Shu-Huei Wang , Mei-Chun Lin , Tien-Lan Shieh , Ying-Huey Huang , Shih-Chieh Chuang , Chi-Hsin Richard King
IPC分类号： A61K33/24 , C07D239/70 , C07D253/10 , A61K31/495 , A61K31/53 , A61K31/439 , A61K31/4375 , A61K31/728 , A61K31/675 , A61K31/337 , A61K31/506 , A61K39/395 , A61K31/505 , A61K31/519 , A61K31/282 , A61P35/00 , A61P37/02
CPC分类号： A61K31/282 , A61K31/337 , A61K31/4375 , A61K31/439 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/555 , A61K31/675 , A61K31/728 , A61K33/24 , A61K45/06 , C07D239/70 , C07D253/10 , C07D409/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D498/04 , A61K2300/00
摘要： This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated disorder.
摘要翻译： 本发明涉及下面所示的式（I）化合物。 式（I）中的每个变量在说明书中定义。 这些化合物可用于治疗运动蛋白Eg5蛋白介导的病症。
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公开(公告)号：US07378524B2
公开(公告)日：2008-05-27
申请号：US10953937
申请日：2004-09-29
申请人： Chu-Chung Lin , Jen-Fuh Liu , Chih-Wei Chang , Shu-Jen Chen , Yibin Xiang , Pei-Chin Cheng , Jiing-Jyh Jan
发明人： Chu-Chung Lin , Jen-Fuh Liu , Chih-Wei Chang , Shu-Jen Chen , Yibin Xiang , Pei-Chin Cheng , Jiing-Jyh Jan
IPC分类号： C07D215/38
CPC分类号： C07D401/14 , A61K31/4745 , A61K31/519 , C07D215/42 , C07D215/44 , C07D215/46 , C07D219/12 , C07D221/16 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification.
摘要翻译： 本发明涉及用与CXCR3受体结合的某些氨基喹啉化合物治疗炎症和免疫疾病。 氨基喹啉化合物被下面所示的式（I）覆盖。 每个变量在规范中定义。
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公开(公告)号：US20080058382A1
公开(公告)日：2008-03-06
申请号：US11834204
申请日：2007-08-06
申请人： Chi-Feng Yen , Chi-Hsin King , Hua-Chien Chen , Gholam Hakimelahi , Shu-Jen Chen , Ying-Huey Huang , Chien-Huang Wu
发明人： Chi-Feng Yen , Chi-Hsin King , Hua-Chien Chen , Gholam Hakimelahi , Shu-Jen Chen , Ying-Huey Huang , Chien-Huang Wu
IPC分类号： A61K31/44 , A61P19/02 , A61P19/10 , A61P25/28 , C07D401/00
CPC分类号： C07D207/335 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/195 , A61K31/44 , A61K31/445 , C07C211/27 , C07C211/29 , C07C211/30 , C07D209/08 , C07D213/38 , C07D213/42 , C07D213/74 , C07D235/14 , C07D257/02 , C07D333/18 , C07D401/14 , C07D409/14 , C07D471/04
摘要： This invention relates to methods for treating retinopathy and repairing tissue damage. The methods include administering to a subject in need thereof an effective amount of one or more compounds of the following formula. Each variable in this formula is defined in the specification.
摘要翻译： 本发明涉及治疗视网膜病变和修复组织损伤的方法。 所述方法包括向有需要的受试者施用有效量的一种或多种下列化合物。 该公式中的每个变量在规范中定义。
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