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公开(公告)号:US12084690B2
公开(公告)日:2024-09-10
申请号:US18488060
申请日:2023-10-17
发明人: Zhaozhong Han , Hongya Pan , Haiyang Li , Lingyu Li
IPC分类号: A61K39/395 , A61K38/43 , A61P25/16 , A61P25/28 , C07K16/18 , C12N9/00 , C12N9/16 , C12N15/63
CPC分类号: C12N9/16 , A61P25/16 , A61P25/28 , C07K16/18 , C12N15/63 , C07K2317/565 , C07K2317/94
摘要: The present application pertains to a fusion protein, comprising a transferrin-binding protein, and an arylsulfatase A (ARSA) or functionally active fragment thereof, wherein the transferrin-binding protein comprises a peptide, an antibody or an antigen-binding fragment of the antibody capable of binding transferrin. The other aspect of the present application provides the preparing methods and the uses of the fusion protein.
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公开(公告)号:US11961587B2
公开(公告)日:2024-04-16
申请号:US17847156
申请日:2022-06-22
发明人: Yibo Jiang
CPC分类号: G11C7/222 , G11C7/1012 , G11C7/1057 , G11C7/1084
摘要: A clock driver comprises: an input multiplexer for receiving a plurality pairs of input clock signals and an input selection signal, and for selectively outputting one pair of the plurality pairs of input clock signals according to the input selection signal; a phase locking loop (PLL) coupled to the input multiplexer to receive one pair of the plurality pairs of input clock signals, and for generating a PLL clock signal according to the received pair of input clock signals; at least two sets of output multiplexers coupled to the PLL to receive the PLL clock signal and an output selection signal, wherein each set of output multiplexers are configured to selectively output the PLL clock signal as a set of output clock signals according to the output selection signal to drive at least one group of memory chips; and a control module configured to detect toggling of the plurality pairs of input clock signals and generate the input selection signal and the output selection signal based on a detection result of the toggling of the plurality pairs of input clock signals.
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公开(公告)号:US11959891B2
公开(公告)日:2024-04-16
申请号:US16089503
申请日:2017-01-05
发明人: Ruijun Tian , Wendong Chen
CPC分类号: G01N30/06 , C07K1/36 , G01N30/6078 , G01N30/89 , G01N2030/065
摘要: Disclosed is a proteomics sample preparation device, comprising a pipette tip, an ion exchange resin filler and a solid-phase extraction membrane. The solid-phase extraction membrane is filled into the lower end of the pipette tip, and the ion exchange resin filler is filled into the lower end of the pipette tip and is located above the solid-phase extraction membrane. The ion exchange resin filler is a strong cation exchange resin filler or a strong anion exchange resin filler. Disclosed is a protein chromatographic separation platform comprising the proteomic reactor and a liquid chromatography-mass spectrometer. Disclosed is the use of the proteomics reactor and protein chromatographic separation platform in the protein identification and protein quantitative analysis of a cell, a tissue or a blood sample.
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公开(公告)号:US11879153B1
公开(公告)日:2024-01-23
申请号:US18045833
申请日:2022-10-12
发明人: Ruoying Tan , Fengwu Zhang , Xinchang Wang , Qing Cong
IPC分类号: C12Q1/68 , C12Q1/686 , C12Q1/6848 , C12Q1/6806
CPC分类号: C12Q1/686 , C12Q1/6806 , C12Q1/6848 , C12Q2600/16
摘要: The present invention relates to a method for detecting nucleic acids by fluorescent PCR. The method combines primer-activated polymerization reaction and specific fluorescence-labeled probe, which detects the target nucleic acid with high selectivity and high specificity.
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公开(公告)号:US11858957B2
公开(公告)日:2024-01-02
申请号:US17359990
申请日:2021-06-28
发明人: Lijing Chen , Roland Joseph Billedeau , Jim Li
IPC分类号: C07H19/167 , C07H19/067 , C07H19/23
CPC分类号: C07H19/167 , C07H19/067 , C07H19/23
摘要: The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.
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公开(公告)号:US11739387B2
公开(公告)日:2023-08-29
申请号:US17329176
申请日:2021-05-25
发明人: Sheng Guo , Xiaobo Chen , Wubin Qian , Henry Li
IPC分类号: C12Q1/6886
CPC分类号: C12Q1/6886 , C12Q2600/156 , C12Q2600/16
摘要: The disclosure provides methods and compositions, e.g., kits, for identifying or authenticating a sample, e.g., a tumor model, based on the genotype of the sample at a group of SNP loci.
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公开(公告)号:US11661452B2
公开(公告)日:2023-05-30
申请号:US16982605
申请日:2019-03-15
申请人: WUXI BIOLOGICS IRELAND LIMITED , CSTONE PHARMACEUTICALS , CSTONE PHARMACEUTICALS (SUZHOU) CO., LTD. , CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD.
发明人: Yunying Chen , Jing Li
IPC分类号: A61K39/395 , A61K39/00 , C12Q1/68 , C12N5/02 , C12N1/20 , C12N15/00 , C07K16/00 , C07K16/46 , C07H21/04 , C07K16/28 , G01N33/68
CPC分类号: C07K16/2803 , G01N33/68 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/70503
摘要: The present disclosure provides anti-LAG-3 heavy-chain antibody or the antigen-binding domain thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.
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公开(公告)号:US11453711B2
公开(公告)日:2022-09-27
申请号:US17467288
申请日:2021-09-06
发明人: Yuanyuan Zhang , Haixia Zou , Xinyu Zhao , Yaoguang Jin , Xu Chen , Peng Zhai , Wei Guo
IPC分类号: C07K14/605 , C07K14/475 , A61K38/00 , A61K47/64
摘要: The present disclosure provides fusion polypeptides comprising GLP-1 and GDF15, the polypeptide complexes, and the conjugates thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
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公开(公告)号:US11417414B2
公开(公告)日:2022-08-16
申请号:US16914457
申请日:2020-06-28
发明人: Gang Shan , Yong Zhang
摘要: The present application discloses an apparatus for repairing a defect of a memory module, comprises: a central buffer having an address recording module for recording defective address information indicating one or more defective memory addresses in the memory module; the central buffer is configured to receive an access command for accessing a target address in the memory module from a memory interface, and to determine whether to generate a repair access command for repairing the target address according to a comparison result; and a data buffer having a data recording module for recording repair data; wherein the data buffer is coupled between the memory interface and the memory module to buffer data interacted therebetween, and is coupled to the central buffer to receive the access command or the repair access command; the data buffer is configured to write target data associated with the access command into the data recording module as repair data corresponding to a target address according to the repair access command, or read repair data from the data recording module as target data corresponding to a target address.
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公开(公告)号:US11414696B1
公开(公告)日:2022-08-16
申请号:US17469897
申请日:2021-09-09
发明人: Yuchao Chen
IPC分类号: C12Q1/6837
摘要: The present disclosure provides a microarray comprising a plurality of probes. Each probe comprises a first oligonucleotide and a second oligonucleotide. The location of each probe on the microarray can be determined by the length of the first oligonucleotide and the length of the second oligonucleotide, thus providing a spatially barcoded microarray. Also provided are the methods of producing such spatially barcoded microarray. Also provided are the method of using such spatially barcoded microarray.
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