公开(公告)号：US10398746B2

公开(公告)日：2019-09-03

申请号：US15420918

申请日：2017-01-31

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Michael Li ,  Markus Krumme

IPC分类号： A61K9/00 ,  A61K36/47 ,  A61K31/192 ,  A61K47/18 ,  A61K47/26 ,  A61K47/38 ,  B29C41/00 ,  A23L27/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K47/46 ,  B29B7/88 ,  B29B13/00 ,  B29C39/02 ,  B29C39/36 ,  B29C39/38 ,  B29C69/00 ,  B29K105/00 ,  B29L7/00

摘要： An edible oral film strip dosage form containing an unpalatable basic active pharmaceutical ingredient and an ion exchange resin as a primary taste masking agent, along with an optional acidic agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

公开(公告)号：US10363228B2

公开(公告)日：2019-07-30

申请号：US13162604

申请日：2011-06-17

申请人： René Eifler ,  Michael Horstmann ,  Regine Kaufmann ,  Patrick Mohr ,  Eric Galia ,  Wolfgang Prange ,  Stefan Buller ,  Klaus Pusecker ,  Jan Stampfuss ,  Susanne Stoelben

发明人： René Eifler ,  Michael Horstmann ,  Regine Kaufmann ,  Patrick Mohr ,  Eric Galia ,  Wolfgang Prange ,  Stefan Buller ,  Klaus Pusecker ,  Jan Stampfuss ,  Susanne Stoelben

IPC分类号： A61F13/00 ,  A61M35/00 ,  A61N1/30 ,  A61K9/70 ,  A61K31/13

摘要： The invention relates to transdermal therapeutic systems (TTS) which include, as active ingredient, the NMDA receptor antagonist memantine or one of its physiologically compatible salts. The TTSs can be produced and used for treating diseases of the central nervous system.

公开(公告)号：US10323138B2

公开(公告)日：2019-06-18

申请号：US15013095

申请日：2016-02-02

申请人： smartpolymer GmbH

发明人： Sabine Riede ,  Marcus Krieg

IPC分类号： A61K9/50 ,  C08L1/02 ,  C09K5/06 ,  D01F1/10 ,  D01F2/00 ,  F28D20/02 ,  A01N25/10 ,  A61K9/70 ,  A61K47/38 ,  D21H21/34 ,  D21H21/36 ,  D21H21/28 ,  D21H21/30 ,  A61K9/16

摘要： The invention relates to a process for producing cellulosic shaped articles with stabilized inclusions in the form of a microfine dispersion of nonpolar organic compounds and mixtures by a dry-wet extrusion process. The shaped articles produced in this way exhibit by comparison with unmodified cellulose fibers a substantially increased storage capacity for nonpolar active substances. They are suitable in particular for use in textiles for clothing, industrial textiles, leisure, medicine and cosmetics. Potential functional effects imparted include the physical effect of heat storage and/or the uniform and finely meterable storage and release of nonpolar active substances and plant extracts from the interior of the fibers of the shaped articles. It is possible through a suitable choice of the nonpolar portion to produce by this process also fibers capable of absorbing liquid or gaseous nonpolar substances.

公开(公告)号：US10292942B2

公开(公告)日：2019-05-21

申请号：US12302065

申请日：2007-05-30

申请人： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

发明人： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

IPC分类号： A61K9/70

摘要： The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

公开(公告)号：US10264798B2

公开(公告)日：2019-04-23

申请号：US13913544

申请日：2013-06-10

申请人： Kalle GmbH

发明人： Matthias Pohl ,  Nico Michaelis

IPC分类号： A22C13/00

摘要： A biopolymer-based food casing having an impregnation on the side facing the food is provided. The impregnation includes at least one hydrophobic, synthetic, organic polymer. By taloring the impregnation, the peelability of the casing may be adjusted to correspond to the type of food contained within the casing. The casing is used, especially, as an artificial sausage casing for raw sausage, scalded-emulsion sausage or cooked-meat sausage.

公开(公告)号：US09687445B2

公开(公告)日：2017-06-27

申请号：US13445716

申请日：2012-04-12

申请人： Michael Hsin Chwen Li

发明人： Michael Hsin Chwen Li

IPC分类号： A61K9/00 ,  A61K47/38 ,  A61K47/32 ,  A61K31/485 ,  A61K45/06 ,  A61K9/16

CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/485 ,  A61K45/06 ,  A61K47/32 ,  A61K47/38 ,  A61K2300/00

摘要： A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.

公开(公告)号：US09585406B2

公开(公告)日：2017-03-07

申请号：US12356615

申请日：2009-01-21

申请人： Ulrich Delius

发明人： Ulrich Delius

IPC分类号： A22C13/00

CPC分类号： A22C13/00 ,  A22C2013/0069 ,  A22C2013/0093

摘要： The invention relates to uncooked dry or semi-dry sausage products in tubular casings that are based on an optionally-coated textile material. The tubular casing has a longitudinal seam with a sealing strip. On the sealing strip is located a discontinuous layer of a sealing polymer. The sealing strip is bonded to the casing essentially at sealing points defined by the discontinuous layer. The invention further relates to a process for producing the uncooked dry or semi-dry sausage product.

摘要翻译： 本发明涉及基于任选涂布的纺织材料的管状肠衣中的未煮干的干或半干香肠产品。 管状壳体具有带密封条的纵向接缝。 在密封条上设置密封聚合物的不连续层。 密封条基本上在由不连续层限定的密封点处接合到壳体。 本发明还涉及生产未煮熟的干或半干香肠制品的方法。

公开(公告)号：US09534099B2

公开(公告)日：2017-01-03

申请号：US13053409

申请日：2011-03-22

申请人： Leo Mans ,  Norbert Tueschen

发明人： Leo Mans ,  Norbert Tueschen

IPC分类号： D21H13/02 ,  C08J9/00 ,  A47L13/16 ,  B32B23/10

CPC分类号： C08J9/0085 ,  A47L13/16 ,  B32B5/18 ,  B32B5/245 ,  B32B23/10 ,  B32B2266/02 ,  B32B2270/00 ,  B32B2307/546 ,  B32B2307/554 ,  B32B2307/7163 ,  B32B2307/732 ,  B32B2432/00 ,  C08J2201/0444 ,  C08J2301/02 ,  D21H13/02

摘要： A cellulose sponge cloth containing a net or grid as internal reinforcement is provided, with the sponge cloth further including a uniform distribution of fibers and/or durably softening polymers that are not water-leachable. The sponge cloth is produced by the viscose process by mixing with the fibers and/or the softening polymers and the pore former with cellulose xanthate and forming the resulting sponge cloth raw material into a thin layer. The grid or net is placed onto this layer, followed by a further layer of the sponge cloth raw material. Coagulation and regeneration baths and optional wash baths are used to dissolve the pore former out of the sponge cloth and regenerate the cellulose. The sponge cloth is bend-resistant, it does not break in the dry state. The sponge cloth is envisioned for cleaning and decontamination.

摘要翻译： 提供了一种含有网或网格作为内部加强筋的纤维素海绵布，其中海绵布还包括均匀分布的纤维和/或耐久地软化不可水浸的聚合物。 通过与纤维和/或软化聚合物和成孔剂与纤维素黄原酸酯混合并将所得海绵布原料混合成薄层，通过粘胶工艺生产海绵布。 将网格或网放置在该层上，然后再铺设一层海绵布原料。 凝结和再生浴和任选的洗涤浴用于将成孔剂从海绵布中溶解并再生纤维素。 海绵布是抗弯曲的，在干燥状态下不会破裂。 海绵布被设想用于清洁和去污。

公开(公告)号：US09403770B2

公开(公告)日：2016-08-02

申请号：US12374539

申请日：2007-07-25

申请人： Giorgio Bertolini ,  Maurizio Gallina ,  Giuseppe Motta ,  Domenico Vergani

发明人： Giorgio Bertolini ,  Maurizio Gallina ,  Giuseppe Motta ,  Domenico Vergani

IPC分类号： C07D211/22

CPC分类号： C07D211/22

摘要： A process for preparing fexofenadine is described, which provides for the hydrolysis of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid-alkyl ester, in a mixture of water and optionally an organic solvent, in the presence of a base; the carboxylate salt of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid is thus obtained, which is then directly reduced as carboxylate in a basic environment with hydrogen in the presence of a suitable hydrogenation catalyst to give the carboxylate of fexofenadine, which is precipitated by neutralization of the solution.

摘要翻译： 描述了制备非索非那定的方法，其提供4- [4- [4-（羟基二苯基甲基）-1-哌啶基] -1-氧代丁基]-α，α-二甲基苯乙酸 - 烷基酯在水溶液 水和任选的有机溶剂，在碱的存在下; 由此得到4- [4- [4-（羟基二苯基甲基）-1-哌啶基] -1-氧代丁基]-α，α-二甲基苯乙酸的羧酸盐，然后在碱性环境中用氢气将其直接还原为羧酸盐 存在合适的氢化催化剂以得到通过溶液中和而沉淀的非索非那定的羧酸盐。

公开(公告)号：US09074407B2

公开(公告)日：2015-07-07

申请号：US12700809

申请日：2010-02-05

申请人： Holger Kliesch ,  Lothar Bothe ,  Dirk Broeder ,  Ingo Fischer

发明人： Holger Kliesch ,  Lothar Bothe ,  Dirk Broeder ,  Ingo Fischer

IPC分类号： B32B5/00 ,  B29C47/06 ,  E06B9/08 ,  E06B9/386 ,  E06B9/24 ,  C08K5/49 ,  C08K5/00 ,  B29C47/00 ,  B32B27/08 ,  B32B27/20 ,  B32B27/36 ,  B32B7/02 ,  B29C47/14 ,  B29C47/88 ,  B29C55/14 ,  B29K67/00 ,  B29K105/00 ,  B29L31/00

CPC分类号： E06B9/24 ,  B29C47/0021 ,  B29C47/065 ,  B29C47/14 ,  B29C47/145 ,  B29C47/8805 ,  B29C47/8815 ,  B29C47/8845 ,  B29C47/887 ,  B29C55/143 ,  B29K2067/00 ,  B29K2105/0026 ,  B29K2105/0032 ,  B29K2105/005 ,  B29K2105/256 ,  B29L2031/7192 ,  B32B7/02 ,  B32B27/08 ,  B32B27/20 ,  B32B27/36 ,  B32B2250/244 ,  B32B2307/3065 ,  B32B2307/40 ,  B32B2307/416 ,  B32B2307/518 ,  B32B2307/71 ,  B32B2451/00 ,  B32B2457/20 ,  C08K5/0066 ,  C08K5/49 ,  E06B9/386 ,  Y10T428/2495 ,  Y10T428/24975 ,  Y10T428/265 ,  Y10T428/2982

摘要： The invention relates to an at least three-layer, biaxially oriented polyester film with a carbon-black-filled outer layer and with two TiO2-containing layers, where a TiO2-containing layer is also an outer layer and where the thickness of the outer layers is from 4 to 15 μm, the thickness of the base layer is ≧the total of the thicknesses of the outer layers, the white outer layer includes at least 15% by weight of TiO2, the base layer includes at least 4% by weight of TiO2, the carbon-black-containing outer layer includes from 3 to 15% by weight of carbon black, and the SV value of the film is at least 600, where all % by weight data are based on the weight of the respective layer, and also to a process for the production of this type of film and to the use of the film in particular in blinds, including roller blinds, Venetian blinds, or projection screens, or in displays.

摘要翻译： 本发明涉及一种至少三层双轴取向的聚酯薄膜，其具有填充炭黑的外层和两个含TiO 2的层，其中含TiO 2的层也是外层，其中外层的厚度 层的厚度为4〜15μm，基层的厚度为外层的厚度的总和，白色外层为TiO 2的至少15重量％，基底层为至少4重量％ 的TiO 2，含炭黑的外层包含3〜15重量％的炭黑，并且膜的SV值为至少600，其中所有重量％的数据都是基于各层的重量 ，以及制造这种类型的薄膜的方法以及特别是在百叶窗，百叶帘或投影屏幕或显示器中的薄片中使用该薄膜。