公开(公告)号：US10086061B2

公开(公告)日：2018-10-02

申请号：US15550433

申请日：2016-03-10

申请人： The United States of America, as represented by the Secretary of the Army, on behalf of the Walter Reed Army Institute of Research

发明人： Stephen J. Thomas ,  Kenneth H. Eckels ,  Joseph R. Putnak

IPC分类号： A61K39/12 ,  A61K39/395 ,  A61K39/00 ,  C12N7/00

摘要： Immunogenic compositions comprising one or more inactivated dengue viruses and one or more inactivated non-dengue flaviviruses and methods of making and using thereof are provided.

公开(公告)号：US10577578B2

公开(公告)日：2020-03-03

申请号：US15553328

申请日：2016-03-10

申请人： WALTER REED ARMY INSTITUTE OF RESEARCH DEPARTMENT OF THE ARMY ,  Tatyana Savransky ,  Jackie Williams

发明人： Tatyana Savransky ,  Jackie Williams

IPC分类号： C12N1/10 ,  C12N13/00 ,  C12N3/00

摘要： Described in this application is a method for producing Plasmodium sporozoites in a cell-free, mosquito-free in vitro culture-system. Compositions and methods resulting from applying the methods of the present invention are described.

公开(公告)号：US20180064803A1

公开(公告)日：2018-03-08

申请号：US15693650

申请日：2017-09-01

申请人： Janssen Vaccines & Prevention B.V. ,  Beth Israel Deaconess Medical Center, Inc. ,  Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc ,  Walter Reed Army Institute of Research

发明人： Frank TOMAKA ,  Maria Grazia PAU ,  Johanna SCHUITEMAKER ,  Dan BAROUCH ,  Jintanat ANANWORANICH ,  Merlin ROBB ,  Nelson L. MICHAEL ,  Jerome KIM

IPC分类号： A61K39/21 ,  C12N7/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/70 ,  A61P31/18 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2710/24043 ,  C12N2710/24143 ,  C12N2740/16021 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12N2740/16234 ,  C12N2740/16271

摘要： Methods for inducing an immune response against Human Immunodeficiency Virus (HIV) in HIV-infected subjects undergoing antiretroviral therapy (ART) are described. The methods include administering an adenovirus vector primer vaccine and a modified vaccinia virus (MVA) vector booster vaccine encoding mosaic HIV antigens.

公开(公告)号：US10881684B2

公开(公告)日：2021-01-05

申请号：US16083497

申请日：2017-06-26

申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE ARMY, ON BEHALF OF THE WALTER REED ARMY INSTITUTE OF RESEARCH

发明人： Robert W. Kaminski ,  Kevin R. Turbyfill ,  Edwin V. Oaks ,  Kristen Clarkson

IPC分类号： A61K31/739 ,  A61K39/39 ,  A61P37/04 ,  A61K39/112 ,  C07K14/25 ,  A61K38/16 ,  A61K45/06 ,  A61K47/69 ,  A61K47/61 ,  A61K9/00 ,  A61K39/00

摘要： Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof.

公开(公告)号：US09193739B2

公开(公告)日：2015-11-24

申请号：US14377126

申请日：2013-02-08

申请人： Walter Reed Army Institute of Research

发明人： Carl R. Alving ,  Gary R. Matyas ,  Arthur E. Jacobson ,  Fuying Li ,  Malliga R. Iyer ,  Kenner C. Rice ,  Kejun Cheng ,  Alexander Mayorov

IPC分类号： A61K31/485 ,  C07D489/02 ,  C07K16/00 ,  C07D497/08 ,  A61K47/48 ,  C07K16/18 ,  A61K39/00

CPC分类号： C07D497/08 ,  A61K31/439 ,  A61K31/485 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

摘要： In this application is described a composition and method for inducing in a subject anti-hapten antibodies without inducing antibodies to the carrier protein. Kits for designing and making compositions with desired haptens are also described.

摘要翻译： 在本申请中描述了在受试者抗半抗原抗体中诱导而不诱导针对载体蛋白的抗体的组合物和方法。 还描述了用于设计和制备具有期望的半抗原的组合物的试剂盒。

公开(公告)号：US20150098935A1

公开(公告)日：2015-04-09

申请号：US14377126

申请日：2013-02-08

申请人： Walter Reed Army Institute of Research

发明人： Carl R. Alving ,  Gary R. Matyas ,  Arthur E. Jacobson ,  Fuying Li ,  Malliga R. Iyer ,  Kenner C. Rice ,  Kejun Cheng ,  Alexander Mayorov

IPC分类号： C07D497/08 ,  C07K16/18 ,  A61K47/48

CPC分类号： C07D497/08 ,  A61K31/439 ,  A61K31/485 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76

摘要： In this application Is described a composition and method for Inducing In a subject anti-hapten antibodies without Inducing antibodies to the carrier protein. Kits for designing and making compositions with desired haptens are also described. In this application Is disclosed a synthetic liposome composition comprising liposomes (L) containing monophosphoryl lipid A (MPLA) [L(MPLA)] and an immunoconjugate comprising a carrier and a hapten. In one embodiment, the carrier is a 23 amino acid hydrophobic membrane proximal external region peptide (MPER) derived from the gp41 transmembrane protein of HIV-1 that spontaneously associates with the outer surface of bilayers of liposomes containing MPLA during liposome formation.

摘要翻译： 在本申请中描述了用于诱导受试者抗半抗原抗体而不诱导对载体蛋白的抗体的组合物和方法。 还描述了用于设计和制备具有期望的半抗原的组合物的试剂盒。 在本申请中公开了包含含有单磷酰脂质A（MPLA）[L（MPLA）]的脂质体（L）和包含载体和半抗原的免疫缀合物的合成脂质体组合物。 在一个实施方案中，载体是衍生自HIV-1的gp41跨膜蛋白的23个氨基酸疏水性膜近端外部区域肽（MPER），其在脂质体形成期间与含有MPLA的脂质体的双层的外表面自发缔合。

公开(公告)号：US20170240618A1

公开(公告)日：2017-08-24

申请号：US15505375

申请日：2015-08-21

申请人： WALTER REED ARMY INSTITUTE OF RESEARCH DEPARTMENT OF THE ARMY

发明人： Daniel V. Zurawski

IPC分类号： C07K16/12 ,  C12N1/20 ,  G01N33/569

CPC分类号： C07K16/1203 ,  A61K2039/505 ,  C07K16/1217 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/70 ,  C12N1/20 ,  G01N33/56911 ,  G01N2333/212

摘要： Described are a therapeutic monoclonal antibody specific for the Type Six Secretion System (T6SS) needle protein of Acinetobacter baumannii (A. baumannii) and methods of use. Specifically, the antibody specifically binds to hemolysin co-regulated protein (Hep). Further disclosed are methods of using an anti-Hep antibody for detecting A. baumannii in a sample as well as a mutant A. baumannii strain comprising a deletion or mutation in its genome such that said deletion or mutation interrupts the proper translation of its hep protein.

公开(公告)号：US09334246B2

公开(公告)日：2016-05-10

申请号：US14426275

申请日：2014-03-13

申请人： The United States of America, as represented by the Secretary of the Army, on behalf of the Walter Reed Army Institute of Research

发明人： Richard J. Sciotti ,  Gregory A. Reichard ,  Kristina M. Pannone ,  Victor E. Zottig

IPC分类号： C07D251/42 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  A61K31/53 ,  A61P33/06 ,  C07D251/22 ,  C07D251/18 ,  C07D487/08 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/08

CPC分类号： A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D251/18 ,  C07D251/22 ,  C07D251/42 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D487/08 ,  C07D491/08 ,  Y02A50/411

摘要： Disclosed herein are triazine compounds and methods of making and using thereof to treat malaria, provide chemoprophylaxis, and/or treat or inhibit infection by one or more Plasmodium spp.

摘要翻译： 本文公开了三嗪化合物及其制备和用途以治疗疟疾，提供化学预防和/或治疗或抑制一种或多种疟原虫感染的方法。

公开(公告)号：US20140335126A1

公开(公告)日：2014-11-13

申请号：US14363131

申请日：2012-12-05

申请人： DUKE UNIVERSITY ,  THE GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ,  ARMY INSTITUTE OF RESEARCH ,  NEW YORK UNIVERSITY

发明人： Barton F. Haynes ,  Huaxin Liao ,  Jerome Kim ,  Nelson Michael ,  Susan B. Zolla-Pazner

IPC分类号： C07K14/005 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C07K14/162 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2710/24043 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

摘要翻译： 本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及用于HIV-1的疫苗及其制备和使用方法。

公开(公告)号：US20140294892A1

公开(公告)日：2014-10-02

申请号：US14305572

申请日：2014-06-16

申请人： The U.S.A, as represented by the Secretary, Department of Health & Human Services ,  The Walter Reed Army Institute of Research

发明人： Alexander G. Pletnev ,  Joseph R. Putnak ,  Robert M. Chanock ,  Brian R. Murphy ,  Stephen S. Whitehead ,  Joseph E. Blaney

IPC分类号： A61K39/12 ,  C12Q1/68

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24162 ,  C12Q1/6888 ,  Y02A50/386 ,  Y02A50/394

摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

摘要翻译： 本发明涉及建立在用于产生免疫原性，活的，减毒的西尼罗病毒疫苗的登革病毒骨架上的减毒，免疫原性的西尼罗病毒嵌合体。