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公开(公告)号：US20070072797A1
公开(公告)日：2007-03-29
申请号：US11410540
申请日：2006-04-25
申请人： Martyn Robinson , Alistair Henry , Alastair Lawson , Hsieng Lu , Christopher Paszty , Kelly Hoffmann , John Latham , David Winkler , Aaron Winters
发明人： Martyn Robinson , Alistair Henry , Alastair Lawson , Hsieng Lu , Christopher Paszty , Kelly Hoffmann , John Latham , David Winkler , Aaron Winters
IPC分类号： A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20070110747A1
公开(公告)日：2007-05-17
申请号：US11411003
申请日：2006-04-25
申请人： Christopher Paszty , Martyn Robinson , Kevin Graham , Alistair Henry , Kelly Hoffmann , John Latham , Hsieng Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron Winters
发明人： Christopher Paszty , Martyn Robinson , Kevin Graham , Alistair Henry , Kelly Hoffmann , John Latham , Hsieng Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron Winters
IPC分类号： A61K39/395 , G01N33/567 , C07K16/18
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US07592429B2
公开(公告)日：2009-09-22
申请号：US11411003
申请日：2006-04-25
申请人： Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
发明人： Christopher Paszty , Martyn Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David Winkler , Aaron George Winters
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US08003108B2
公开(公告)日：2011-08-23
申请号：US11410540
申请日：2006-04-25
申请人： Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
发明人： Hsieng Sen Lu , Christpher Paszty , Martyn Kim Robinson , Alistair James Henry , Kelly Sue Warmington , John Latham , Alastair Lawson , David Winkler , Aaron George Winters
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20090304713A1
公开(公告)日：2009-12-10
申请号：US12276889
申请日：2008-11-24
申请人： Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
发明人： Christoper Paszty , Martin Kim Robinson , Kevin Graham , Alistair James Henry , Kelly Sue Hoffmann , John Latham , Hsieng Sen Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron George Winters
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K7/06 , C07K7/08 , C07K19/00 , C07K14/76 , C07K14/79
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US07872106B2
公开(公告)日：2011-01-18
申请号：US12276889
申请日：2008-11-24
申请人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
发明人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：US20110097342A1
公开(公告)日：2011-04-28
申请号：US12950094
申请日：2010-11-19
申请人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
发明人： Christopher J. Paszty , Martyn K. Robinson , Kevin Graham , Alistair J. Henry , Kelly S. Warmington , John Latham , Hsieng S. Lu , Alastair Lawson , Andy Popplewell , Wenyan Shen , David G. Winkler , Aaron G. Winters
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , C07K7/06 , C07K7/08 , A61P19/08 , A61P19/10
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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8.发明申请Antibodies specific for sclerostin and methods for increasing bone mineralization 有权针对硬皮蛋白的特异性抗体和增加骨矿化的方法公开(公告)号：US20050106683A1
公开(公告)日：2005-05-19
申请号：US10868497
申请日：2004-06-15
申请人： David Winkler , Jiye Shi , John Latham
发明人： David Winkler , Jiye Shi , John Latham
CPC分类号： C07K16/22 , A61K47/643 , A61K47/646 , C07K14/475 , C07K14/51 , C07K16/18 , C07K2317/76 , G01N33/6854 , G01N2333/4704
摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
摘要翻译： 提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。
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公开(公告)号：US20050085418A1
公开(公告)日：2005-04-21
申请号：US10799162
申请日：2004-03-12
申请人： David Winkler , John Latham , John Skonier , Diana Shpektor , Trenton Hayes , James Geoghegan
发明人： David Winkler , John Latham , John Skonier , Diana Shpektor , Trenton Hayes , James Geoghegan
IPC分类号： A61K20060101 , A61K38/18 , A61P19/00 , C07K14/475 , C07K14/51 , C07K14/705 , G01N33/53 , G01N33/74
CPC分类号： C07K14/51 , C07K14/475 , G01N33/74 , G01N2500/00
摘要： Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.
摘要翻译： 提供了组合物和方法，其涉及（i）TGF-β结合蛋白质硬化蛋白与BMP拮抗剂蛋白质chordin形成复合物的意想不到的特异性关联，和（ii）TGF-β结合蛋白质硬化蛋白与BMP拮抗剂 蛋白质头蛋白以形成复合物，其中复合物不能与TGF-β超家族成员如BMP结合。 本发明提供用于筛选测定法的分离的复合物，以鉴定调节骨矿化的药剂，并提供其它相关优点。
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公开(公告)号：US10150968B2
公开(公告)日：2018-12-11
申请号：US13589584
申请日：2012-08-20
申请人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
发明人： Danielle Marie Mitchell , Leon F. Garcia-Martinez , Patricia Dianne McNeill , Ethan Wayne Ojala , Mehmet Inan , John Latham
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
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