利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.046 秒)

    RADIOPROTECTOR COMPOUNDS AND METHODS
    7.
    发明申请
    RADIOPROTECTOR COMPOUNDS AND METHODS 有权
    放射性化合物和方法

    公开(公告)号：US20130109678A1

    公开(公告)日：2013-05-02

    申请号：US13640188

    申请日：2011-04-06

    申请人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Maruccio

    发明人： Roger Francis Martin ,  Jonathan White ,  Pavel Lobachevsky ,  David Winkler ,  Colin Skene ,  Sebastian Maruccio

    IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14

    CPC分类号： C07D401/14 ,  C07D235/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14

    摘要： The invention relates to novel compounds, processes for their preparation and their use in protecting biological materials from radiation damage (radioprotection). Preferred compounds of the invention are those of Formula II, as follows: wherein W represents —N(R1R2) where R1 and R2 are not both hydrogen and where they may together form a 5, 6 or 7 membered ring structure, —NHN(R1R2), —NHR3N(R1R2), —NHR3OR2, —N(R3)R3OR2, —N(R1)R3OR3OR3, —OR3NR1R2, —OR3 or W represents piperidyl, piperazinyl, morpholinyl, thiomorpholinyl or diazepanyl each of which may be optionally substituted by C1 to C4 alkyl, C2 to C4 alkenyl, —N(CO)N(R1R2), —N(CO)OR1, —N(CO)OR3OH, —(CO)NR1R2, —R3(CO)NR1R2, —R3OR1, —OR1, —N(R1R2) or —NH—; R1 and R2 are the same or different and are selected from hydrogen, C1 to C4 alkyl or C2 to C4 alkenyl; R3 is a C1 to C4 alkyl or C2 to C4 alkenyl group or chain; Z is the same or different and represents N or CH; Z′ is the same or different and represents N or C; X represents CH, N or NH, where is a double bond when X is CH or N and a single bond when X is NH; X′ represents N or NH, wherein when X is CH or NX′ is NH and wherein X and X′ are different and further where is a double bond when X′ is N and a single bond when X′ is NH; Q represents H, alkoxyl, —NR1R2, F or Cl; Q1 is absent when Z′ is N and when Z′ is C it represents H, alkoxyl, —NR1R2, F or Cl; A represents a five to ten membered single or multiple ring structure with heterocyclic N or O located at the ortho position, said ring including optional double bonds, substitutions and/or other heteroatoms and pharmaceutically acceptable derivatives thereof.

    摘要翻译： 本发明涉及新化合物，其制备方法及其在保护生物材料免受辐射损伤（放射防护）中的应用。 本发明优选的化合物是式II的化合物，其如下：其中W表示-N（R 1 R 2），其中R 1和R 2不是氢并且它们可以一起形成5,6或7元环结构，-NHN（R 1 R 2 ），-NHR3N（R1R2），-NHR3OR2，-N（R3）R3OR2，-N（R1）R3OR3OR3，-OR3NR1R2，-OR3或W表示哌啶基，哌嗪基，吗啉基，硫代吗啉基或二氮杂环丁基， C 1 -C 4烷基，C 2〜C 4烯基，-N（CO）N（R 1 R 2），-N（CO）OR 1，-N（CO）OR 3 OH， - （CO）NR 1 R 2，-R 3（CO）NR 1 R 2，-R 3 OR 1， -OR1，-N（R1R2）或-NH-; R 1和R 2相同或不同，并且选自氢，C 1至C 4烷基或C 2至C 4链烯基; R3是C1-C4烷基或C2-C4链烯基或链; Z相同或不同，代表N或CH; Z'相同或不同，表示N或C; X表示CH，N或NH，当X为CH或N时为双键，当X为NH时为单键; X'表示N或NH，其中当X是CH或NX'是NH并且其中X和X'不同，并且当X'是N时是双键，当X'是NH时，是单键; Q表示H，烷氧基，-NR1R2，F或Cl; 当Z'为N时，Q1不存在，当Z'为C时，它代表H，烷氧基，-NR1R2，F或Cl; A表示具有位于邻位的杂环N或O的五至十元单环或多环结构，所述环包括任选的双键，取代和/或其它杂原子及其药学上可接受的衍生物。

    Producing a locally optimal path through a lattice by overlapping search
    9.
    发明申请
    Producing a locally optimal path through a lattice by overlapping search 失效
    通过重叠搜索生成通过网格的局部最优路径

    公开(公告)号：US20070005551A1

    公开(公告)日：2007-01-04

    申请号：US11170424

    申请日：2005-06-29

    申请人： David Winkler

    发明人： David Winkler

    IPC分类号： G06F17/30

    CPC分类号： G06Q10/047 ,  Y10S707/99931 ,  Y10S707/99935 ,  Y10S707/99942 ,  Y10S707/99943 ,  Y10S707/99944

    摘要： A system and computer-implemented method for the creation of a structure using Lego building blocks is disclosed. Aspects of the methods are equally appropriate for numerous structures, including but not limited to, studs-up and studs-out configurations or a ‘wall’ style mosaic or a ‘floor’ style mosaic. Given the systems and methods disclosed, aspects of the invention are applicable to three-dimensional sculpture structures too. The system and method may use a recursive overlapping divide-and-conquer breadth-first search feature to improve the quality of the structures while only slightly, if at all, increasing the time and memory required. Furthermore, the system and method may use dithering algorithms and/or cost analysis to determine which building block can be used and placed to achieve high-quality structures. In another example, aspects of the invention may be used to more optimally schedule delivery trucks. In yet another example, aspects of the invention may be used to enhance handwriting recognition and speech recognition.

    摘要翻译： 公开了一种用于使用乐高构建块创建结构的系统和计算机实现的方法。 这些方法的各个方面对于许多结构同样适用，包括但不限于分支和分支结构或“墙”式马赛克或“地板”式马赛克。 鉴于所公开的系统和方法，本发明的方面也适用于三维雕塑结构。 该系统和方法可以使用递归重叠的划分和征服宽度优先搜索特征来提高结构的质量，而仅稍微增加所需的时间和记忆。 此外，系统和方法可以使用抖动算法和/或成本分析来确定哪个构建块可以被使用和放置以实现高质量的结构。 在另一个示例中，本发明的各方面可用于更好地安排运送卡车。 在又一示例中，本发明的各方面可用于增强手写识别和语音识别。