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公开(公告)号：US09164015B2
公开(公告)日：2015-10-20
申请号：US13538898
申请日：2012-06-29
Applicant: Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
IPC: H01L27/146 , G01N1/31
CPC classification number: G01N1/312
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
Abstract translation: 一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品 从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。
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公开(公告)号：US08673643B2
公开(公告)日：2014-03-18
申请号：US12957203
申请日：2010-11-30
Applicant: Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
CPC classification number: G01N1/312 , G01N2001/368
Abstract: A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.
Abstract translation: 提供了一种用于染色生物样品的闭环自动化方法。 该方法包括提供生物样品，通过在试剂中流动来染色生物样品的至少一部分，监测生物样品的一种或多种光学特性，以及基于至少一种光学特性来计算品质因数。 还提供了用于生物样品的迭代染色的自动装置。
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公开(公告)号：US20130287645A1
公开(公告)日：2013-10-31
申请号：US13458092
申请日：2012-04-27
Applicant: Kashan Ali Shaikh , Jessica Marie Godin , Alex David Corwin , Robert John Filkins
Inventor： Kashan Ali Shaikh , Jessica Marie Godin , Alex David Corwin , Robert John Filkins
CPC classification number: B32B37/0076 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0655 , B32B37/182 , B32B38/0008 , B32B2535/00 , Y10T156/10 , Y10T156/1056 , Y10T156/108
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. Methods for fabricating the subassembly and assembled flow cell are also provided. The method includes the steps of adhering a gasket layer to a substrate layer, wherein the gasket layer may contain enclosed features and adhering an adherent layer to the gasket layer. The subassembly may be sealed against a solid support to form a flow cell.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 还提供了用于制造子组件和组装流动池的方法。 该方法包括以下步骤：将衬垫层粘附到衬底层，其中衬垫层可以包含封闭特征并将粘附层粘附到衬垫层。 子组件可以密封在固体支撑件上以形成流动池。
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公开(公告)号：US08093971B2
公开(公告)日：2012-01-10
申请号：US12340775
申请日：2008-12-22
Applicant: Xuefeng Wang , Alex David Corwin , Bo Li , Kanakasabapathi Subramanian , Kuna Venkat Satya Rama Kishore
Inventor： Xuefeng Wang , Alex David Corwin , Bo Li , Kanakasabapathi Subramanian , Kuna Venkat Satya Rama Kishore
IPC: H01H51/22
CPC classification number: H01H59/0009 , H01H1/0036 , H01H2001/0078 , H01H2001/0084 , Y10T29/49105
Abstract: A micro electromechanical system switch having an electrical pathway is presented. The switch includes a first portion and a second portion. The second portion is offset to a zero overlap position with respect to the first portion when the switch is in open position (or in the closed position depending on the switch architecture). The switch further includes an actuator for moving the first portion and the second portion into contact.
Abstract translation: 提出了具有电路径的微机电系统开关。 开关包括第一部分和第二部分。 当开关处于打开位置时（或根据开关结构处于闭合位置），第二部分相对于第一部分偏移到零重叠位置。 开关还包括用于使第一部分和第二部分移动接触的致动器。
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公开(公告)号：US20100155203A1
公开(公告)日：2010-06-24
申请号：US12340775
申请日：2008-12-22
Applicant: Xuefeng Wang , Alex David Corwin , Bo Li , Kanakasabapathi Subramanian , Kuna Venkat Satya Rama Kishore
Inventor： Xuefeng Wang , Alex David Corwin , Bo Li , Kanakasabapathi Subramanian , Kuna Venkat Satya Rama Kishore
CPC classification number: H01H59/0009 , H01H1/0036 , H01H2001/0078 , H01H2001/0084 , Y10T29/49105
Abstract: A micro electromechanical system switch having an electrical pathway is presented. The switch includes a first portion and a second portion. The second portion is offset to a zero overlap position with respect to the first portion when the switch is in open position (or in the closed position depending on the switch architecture). The switch further includes an actuator for moving the first portion and the second portion into contact.
Abstract translation: 提出了具有电路径的微机电系统开关。 开关包括第一部分和第二部分。 当开关处于打开位置时（或根据开关结构在关闭位置），第二部分相对于第一部分偏移到零重叠位置。 开关还包括用于使第一部分和第二部分移动接触的致动器。
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Patent Agency Ranking
公开(公告)号：US20140001337A1
公开(公告)日：2014-01-02
申请号：US13538898
申请日：2012-06-29
Applicant: Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
IPC: H01L27/146
CPC classification number: G01N1/312
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
Abstract translation: 一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品 从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。
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公开(公告)号：US20140055853A1
公开(公告)日：2014-02-27
申请号：US13595175
申请日：2012-08-27
Applicant: Alex David Corwin , Robert John Filkins , Kashan Ali Shaikh , Adriana Ines Larriera Moreno
Inventor： Alex David Corwin , Robert John Filkins , Kashan Ali Shaikh , Adriana Ines Larriera Moreno
CPC classification number: G01N1/31 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L9/527 , B01L2300/041 , B01L2300/046 , B01L2300/0822 , B01L2300/0877 , G01N1/312 , G01N2001/317
Abstract: An open top microfluidic device comprising a microfluidic slide carrier and one or more multiplexing stations is provided which allows sequential staining and imaging without the need for using or removing a coverslip on a mounted biological sample.
Abstract translation: 提供了包括微流体载玻片载体和一个或多个多路复用站的开口顶部微流体装置，其允许顺序染色和成像，而不需要在安装的生物样品上使用或去除盖玻片。
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公开(公告)号：US08900529B2
公开(公告)日：2014-12-02
申请号：US13458092
申请日：2012-04-27
Applicant: Kashan Ali Shaikh , Jessica Marie Godin , Alex David Corwin , Robert John Filkins
Inventor： Kashan Ali Shaikh , Jessica Marie Godin , Alex David Corwin , Robert John Filkins
IPC: B01L99/00
CPC classification number: B32B37/0076 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0655 , B32B37/182 , B32B38/0008 , B32B2535/00 , Y10T156/10 , Y10T156/1056 , Y10T156/108
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. Methods for fabricating the subassembly and assembled flow cell are also provided. The method includes the steps of adhering a gasket layer to a substrate layer, wherein the gasket layer may contain enclosed features and adhering an adherent layer to the gasket layer. The subassembly may be sealed against a solid support to form a flow cell.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 还提供了用于制造子组件和组装流动池的方法。 该方法包括以下步骤：将衬垫层粘附到衬底层，其中衬垫层可以包含封闭特征并将粘附层粘附到衬垫层。 子组件可以密封在固体支撑件上以形成流动池。
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公开(公告)号：US08354899B2
公开(公告)日：2013-01-15
申请号：US12565127
申请日：2009-09-23
Applicant: Christopher Fred Keimel , Marco Francesco Aimi , Shubhra Bansal , Reed Roeder Corderman , Kuna Venkat Satya Rama Kishore , Eddula Sudhakar Reddy , Atanu Saha , Kanakasabapathi Subramanian , Parag Thakre , Alex David Corwin
Inventor： Christopher Fred Keimel , Marco Francesco Aimi , Shubhra Bansal , Reed Roeder Corderman , Kuna Venkat Satya Rama Kishore , Eddula Sudhakar Reddy , Atanu Saha , Kanakasabapathi Subramanian , Parag Thakre , Alex David Corwin
IPC: H01H51/22
CPC classification number: H01H1/0036 , H01H59/0009 , H01H2001/0052 , H01H2001/0084 , Y10T29/49105
Abstract: Provided is a device, such as a switch structure, that includes a contact and a conductive element that is configured to be deformable between a first position in which the conductive element is separated from the contact and a second position in which the conductive element contacts the contact. The conductive element can be formed substantially of metallic material configured to inhibit time-dependent deformation. For example, the metallic material may be configured to exhibit a maximum steady-state plastic strain rate of less than 10−12 s−1 when subject to a stress of at least about 25 percent of a yield strength of the metallic material and a temperature less than or equal to about half of a melting temperature of the metallic material. The contact and the conductive element may be part of a microelectromechanical device or a nanoelectromechanical device. Associated methods are also provided.
Abstract translation: 提供了一种诸如开关结构的装置，其包括触点和导电元件，导电元件被配置为可在导电元件与触点分离的第一位置和导电元件接触的第二位置之间变形 联系。 导电元件可以基本上由配置成抑制时间变形的金属材料形成。 例如，当受到金属材料的屈服强度的至少约25％的应力和金属材料的屈服强度的应力时，金属材料可以被配置为表现出小于10-12s -1的最大稳态塑性应变速率 小于或等于金属材料的熔融温度的大约一半。 接触和导电元件可以是微机电装置或纳米机电装置的一部分。 还提供了相关的方法。
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公开(公告)号：US20120135458A1
公开(公告)日：2012-05-31
申请号：US12957203
申请日：2010-11-30
Applicant: Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
CPC classification number: G01N1/312 , G01N2001/368
Abstract: A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.
Abstract translation: 提供了一种用于染色生物样品的闭环自动化方法。 该方法包括提供生物样品，通过在试剂中流动来染色生物样品的至少一部分，监测生物样品的一种或多种光学特性，以及基于至少一种光学特性来计算品质因数。 还提供了用于生物样品的迭代染色的自动化装置。
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