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    Chemiluminescence detection method and device
    3.
    发明授权
    Chemiluminescence detection method and device 失效
    化学发光检测方法及装置

    公开(公告)号：US06576476B1

    公开(公告)日：2003-06-10

    申请号：US09302158

    申请日：1999-04-29

    申请人： Michael T. Taylor ,  Amer El-Hage ,  Glenn R. Edwards ,  Douglas N. Modlin

    发明人： Michael T. Taylor ,  Amer El-Hage ,  Glenn R. Edwards ,  Douglas N. Modlin

    IPC分类号： G01N2117

    CPC分类号： G01N21/253 ,  G01N21/76 ,  Y10T436/114165

    摘要： A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.

    摘要翻译： 用于从样品中检测化学发光的装置。 该装置可以包括用于支撑样品的台和以下元件中的一个或多个：（1）光学头，（2）用于将化学发光从样品传输到检测器的光中继结构，（3）驱动机构， （4）用于检测光继电器结构对样品的接近度的传感器，（5）用于选择光继电器结构的有效直径的掩模结构，以及（6）用于阻挡外来光进入光中继结构的挡板 。

    Device for projectile dispensing of small volume liquid samples
    5.
    发明授权
    Device for projectile dispensing of small volume liquid samples 失效
    小容量液体样品的射弹分配装置

    公开(公告)号：US5964381A

    公开(公告)日：1999-10-12

    申请号：US968657

    申请日：1997-11-12

    申请人： Amer El-Hage ,  Joseph Leytes

    发明人： Amer El-Hage ,  Joseph Leytes

    IPC分类号： B01L3/02 ,  G01N35/00 ,  B67D5/42 ,  B65D5/72 ,  B67D5/52

    CPC分类号： B01L3/0268 ,  B01L3/022 ,  B01L2400/0478 ,  G01N2035/00237

    摘要： A piston is disposed inside a tube having an inner cross sectional size and shape uniform along its length. The tube has an open end. The piston is free to move linearly inside the tube and preferably may move out of the tube through the open end. If the tube is cylindrical, for example, it has a constant inner diameter. The open end of the tube is neither tapered or flaring. Liquid samples are aspirated into the device by pulling the piston back. The sample is then ejected by accelerating the piston to a minimum velocity to force the liquid sample out of the open end of the tube. The velocity of the sample is sufficient to render negligible the effects of surface tension forces. The volume of the liquid sample dispensed is determined by the inner diameter of the tube and the piston displacement. Accurate positioning of the piston provides samples of accurate volumes. A specific embodiment of the present invention uses a tube with an inner diameter of 0.5 mm, resulting in a volume displacement of 1.9 microliters per centimeter of piston travel.

    摘要翻译： 活塞设置在具有沿其长度的内横截面尺寸和形状均匀的管内。 管具有开口端。 活塞可自由地在管内线性移动，并且优选地可以通过开口端移出管。 如果管是圆柱形的，例如，其具有恒定的内径。 管的开口端既不是锥形的，也不是扩口。 通过拉动活塞将液体样品吸入装置。 然后通过将活塞加速到最小速度来迫使样品离开管的开口端排出样品。 样品的速度足以使表面张力的影响忽略不计。 分配的液体样品的体积由管的内径和活塞位移确定。 活塞的精确定位提供了准确体积的样品。 本发明的具体实施例使用内径为0.5mm的管，导致每厘米活塞行程为1.9微升的体积位移。

    Method of producing a probe for aspirating and dispensing probe having surface sensing capability
    6.
    发明授权
    Method of producing a probe for aspirating and dispensing probe having surface sensing capability 失效
    用于产生具有表面感测能力的吸引和分配探针的探针的方法

    公开(公告)号：US5843378A

    公开(公告)日：1998-12-01

    申请号：US790096

    申请日：1997-01-29

    申请人： Amer El-Hage ,  Rick V. Stellmacher

    发明人： Amer El-Hage ,  Rick V. Stellmacher

    IPC分类号： G01F23/24 ,  G01N35/10 ,  B01L3/02

    CPC分类号： G01N35/1009 ,  G01F23/24 ,  G01F23/245 ,  G01N2035/1025 ,  Y10T436/2575

    摘要： A method of producing a probe for aspirating and dispensing liquid. A fluid conduit and rod are positioned in the central bore of a tube so that an inlet end of the conduit and a contact end of the rod protrude from an upper end of the tube and a discharge end of the conduit and a sensing end of the rod protrude from a lower end of the tube. The tube has a heat-shrinkable outer layer and a meltable inner layer. The tube is heated so that its outer layer shrinks and its inner layer melts to encapsulate middle portions of the conduit and rod. A circuit board having first and second traces and first and second holes is placed on the upper end of the tube so that the inlet end of the conduit is inserted through the first hole and the contact end of the rod is inserted through the second hole. The conduit and rod are attached to the board so that the conduit is electrically connected to the first trace and the rod is electrically connected to the second trace. First and second conducting pins are also attached to the board. The conducting pins electrically connect the traces to a voltage sensing circuit when the probe is attached to a probe positioning device.

    摘要翻译： 一种生产用于吸入和分配液体的探针的方法。 流体导管和杆定位在管的中心孔中，使得导管的入口端和杆的接触端从管的上端突出并且管的排出端和导管的感测端 杆从管的下端突出。 该管具有可热收缩的外层和可熔融的内层。 加热管，使其外层收缩，其内层熔化以封装导管和棒的中间部分。 具有第一和第二迹线和第一和第二孔的电路板被放置在管的上端，使得导管的入口端插入穿过第一孔，并且杆的接触端插入穿过第二孔。 管道和杆被附接到板，使得导管电连接到第一迹线，并且杆电连接到第二迹线。 第一和第二导电引脚也连接到电路板。 当探针附接到探针定位装置时，导电引脚将迹线电连接到电压感测电路。

    Devices and methods for sample analysis
    10.
    发明授权
    Devices and methods for sample analysis 失效
    仪器和样品分析方法

    公开(公告)号：US06486947B2

    公开(公告)日：2002-11-26

    申请号：US09767434

    申请日：2001-01-22

    申请人： Douglas N. Modlin ,  Amer El-Hage ,  John C. Owicki

    发明人： Douglas N. Modlin ,  Amer El-Hage ,  John C. Owicki

    IPC分类号： G01N710

    CPC分类号： G01N21/6452 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/03 ,  G01N2021/0346

    摘要： Devices and methods for containing and analyzing small sample volumes that are sandwiched between solid surfaces. The devices may include an automated drive mechanism that controls the relative positions of the surfaces and an environmental-control mechanism that controls the humidity, temperature, and/or other environmental conditions around the small sample volume. In some embodiments, at least one of the surfaces has a light-transmissive window for allowing optical analysis of a sample contained between the surfaces.

    摘要翻译： 用于容纳和分析夹在固体表面之间的小样品体积的装置和方法。 这些装置可以包括控制表面的相对位置的自动驱动机构和控制小样品体积周围的湿度，温度和/或其他环境条件的环境控制机构。 在一些实施例中，至少一个表面具有用于允许对包含在表面之间的样品进行光学分析的透光窗口。