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公开(公告)号:US4476017A
公开(公告)日:1984-10-09
申请号:US500661
申请日:1983-06-03
申请人: Daniel H. Scharff , Lev J. Leytes
发明人: Daniel H. Scharff , Lev J. Leytes
CPC分类号: C07H21/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00423 , B01J2219/005 , B01J2219/0059 , B01J2219/00596 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N30/6004 , G01N30/6047 , G01N30/6082 , G01N30/6091
摘要: A column for use in DNA synthesis. The column is transparent and is disposable to allow access to the resin beads within the column. The column includes end caps which are engageable with a housing and a screw to secure the column in the housing.
摘要翻译: 用于DNA合成的色谱柱。 该柱是透明的并且是一次性的以允许进入柱内的树脂珠。 该柱包括可与壳体接合的端盖和用于将柱固定在壳体中的螺钉。
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公开(公告)号:US06297018B1
公开(公告)日:2001-10-02
申请号:US09494407
申请日:2000-01-28
申请人: Todd E. French , Douglas N. Modlin , John C. Owicki , James S. Richey , Lev J. Leytes , Enal S. Razvi
发明人: Todd E. French , Douglas N. Modlin , John C. Owicki , James S. Richey , Lev J. Leytes , Enal S. Razvi
IPC分类号: C02Q168
CPC分类号: G01N21/6445 , B01J2219/00315 , B01J2219/00317 , B01J2219/00529 , B01J2219/00605 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L3/50853 , B01L9/523 , B01L2300/0829 , B82Y15/00 , C07K7/06 , C07K7/08 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6858 , C40B60/14 , G01N21/76 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , G01N2333/9121 , C12Q2565/107 , C12Q2561/119
摘要: Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.
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公开(公告)号:US5310523A
公开(公告)日:1994-05-10
申请号:US750325
申请日:1991-08-27
CPC分类号: G01N33/54366 , C12Q1/6813 , C12Q1/682
摘要: A self-contained assembly for assaying an analyte in a liquid sample. The pair of disc-like rotatable plates forming the assembly are relatively rotatable to align reagent reservoirs in one plate with a reaction well in the other plate, for sequential addition of multiple reagents, either in liquid or solid form, to the reaction well. In one embodiment, the reaction well includes solid-phase particles which can be transferred from the reaction well to spaced wells in the assembly by a combination of relative movement of the plate, and rotation of the entire assembly.
摘要翻译: 用于测定液体样品中分析物的独立组件。 形成组件的一对盘状可旋转板相对可旋转,以将一个板中的试剂储存器与另一个板中的反应井对准,以将液体或固体形式的多种试剂顺次加入到反应井中。 在一个实施方案中,反应井包括固相颗粒,其可以通过板的相对运动和整个组件的旋转的组合从反应井转移到组件中的间隔开的孔。
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公开(公告)号:US4690165A
公开(公告)日:1987-09-01
申请号:US898867
申请日:1986-08-20
申请人: Lev J. Leytes , Harry A. Penhasi
发明人: Lev J. Leytes , Harry A. Penhasi
CPC分类号: B01F5/0077 , B01F5/008 , Y10T137/2567 , Y10T137/7843 , Y10T137/7889
摘要: A mixing valve includes a housing having inlet ports and an outlet port that intersect at a valve chamber. A valve core within the valve chamber includes passages in fluid communication with the inlet and outlet ports. The passages intersect at a cavity within the valve core. An elastomeric seal retained within the cavity sealingly engages the valve core around the passages in the absence of fluid pressure in the inlets. Injection of a pressurized fluid in one of the inlets causes the seal to move away from both the corresponding inlet passage to permit fluid flow from the pressurized inlet port to the outlet port and compresses the seal around the other inlet port to provide a tighter seal than existed before application of pressure to the first port.
摘要翻译: 混合阀包括具有入口和与阀室相交的出口的壳体。 阀室内的阀芯包括与入口和出口流体连通的通道。 通道在阀芯内的空腔处相交。 保持在腔内的弹性体密封件在入口处没有流体压力的情况下密封地接合通道周围的阀芯。 在一个入口中注入加压流体使得密封件从相应的入口通道移开,以允许流体从加压入口端口流到出口端口并且压缩围绕另一个入口端口的密封件以提供更紧密的密封件 在向第一港口施加压力之前存在。
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公开(公告)号:US06025985A
公开(公告)日:2000-02-15
申请号:US118341
申请日:1998-07-16
申请人: Lev J. Leytes , William G. Burton , Yong Paik , Glenn R. Edwards , Douglas N. Modlin , Amer El-Hage
发明人: Lev J. Leytes , William G. Burton , Yong Paik , Glenn R. Edwards , Douglas N. Modlin , Amer El-Hage
IPC分类号: G01N21/64 , B01L9/00 , C40B60/14 , F21V21/18 , G01N21/03 , G01N21/17 , G01N21/21 , G01N21/27 , G01N21/76 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G06F1/16
CPC分类号: G01N21/76 , B01L9/523 , B82Y15/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L2300/0829 , C40B60/14 , Y10S436/807 , Y10S436/809 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/25
摘要: A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.
摘要翻译: 一种用于高通量分析仪的可移动控制单元,其可操作地安装在分析仪壳体上的多个位置处。
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公开(公告)号:US06902703B2
公开(公告)日:2005-06-07
申请号:US09777343
申请日:2001-02-05
申请人: Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
发明人: Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
IPC分类号: B01L3/00 , C07F15/00 , C12Q1/68 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L3/02
CPC分类号: G01N35/028 , B01L3/50853 , C07F15/0053 , C12Q1/6816 , C12Q1/6827 , G01N21/253 , G01N21/645 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/2575 , C12Q2565/107
摘要: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
摘要翻译: 本发明提供了用于制备和/或分析样品的综合样品处理系统及其组件。 组件可以包括传输模块,流体模块和分析模块等。
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公开(公告)号:US06488892B1
公开(公告)日:2002-12-03
申请号:US09478819
申请日:2000-01-05
申请人: William G. Burton , Douglas N Modlin , Derrick A. Richardson , Jon F. Petersen , Joseph S. Leytes , John C. Owicki , Amer El-Hage , Lev J. Leytes
发明人: William G. Burton , Douglas N Modlin , Derrick A. Richardson , Jon F. Petersen , Joseph S. Leytes , John C. Owicki , Amer El-Hage , Lev J. Leytes
IPC分类号: G01N2129
CPC分类号: B01L9/523 , B01J2219/00315 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L2300/0829 , B82Y15/00 , C40B60/14 , G01N21/0303 , G01N35/028 , Y10T436/11
摘要: Sample-holding devices and systems for efficiently utilizing relatively small-volume fluid samples.
摘要翻译: 用于有效利用相对小体积流体样品的样品保持装置和系统
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