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    Methods and systems for treating injured cardiac tissue
    1.
    发明申请
    Methods and systems for treating injured cardiac tissue 审中-公开
    治疗受伤心脏组织的方法和系统

    公开(公告)号：US20070093748A1

    公开(公告)日：2007-04-26

    申请号：US11643359

    申请日：2006-12-20

    Applicant: Asha Nayak ,  James Keogh

    Inventor： Asha Nayak ,  James Keogh

    IPC: A61M31/00 ,  A61M37/00

    CPC classification number: A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00392 ,  A61N1/306 ,  A61N1/325 ,  A61N1/36014

    Abstract: Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.

    Abstract translation: 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。

    Devices and methods for interstitial injection of biologic agents into tissue
    2.
    发明申请
    Devices and methods for interstitial injection of biologic agents into tissue 有权
    将生物制剂间插注入组织的装置和方法

    公开(公告)号：US20070049863A1

    公开(公告)日：2007-03-01

    申请号：US11545197

    申请日：2006-10-10

    Applicant: Scott Jahns ,  Gary Oehme ,  Matthew Bonner ,  James Keogh

    Inventor： Scott Jahns ,  Gary Oehme ,  Matthew Bonner ,  James Keogh

    IPC: A61M31/00

    CPC classification number: A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    Abstract: Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    Abstract translation: 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Electrosurgical methods and apparatus for making precise incisions in body vessels
    7.
    发明申请
    Electrosurgical methods and apparatus for making precise incisions in body vessels 有权
    电动手术方法和装置，用于精确切开体内血管

    公开(公告)号：US20070123854A1

    公开(公告)日：2007-05-31

    申请号：US11698332

    申请日：2007-01-26

    Applicant: Cynthia Clague ,  Philip Haarstad ,  Scott Jahns ,  James Keogh ,  Christopher Olig ,  Raymond Usher

    Inventor： Cynthia Clague ,  Philip Haarstad ,  Scott Jahns ,  James Keogh ,  Christopher Olig ,  Raymond Usher

    IPC: A61B18/14

    CPC classification number: A61B18/14 ,  A61B18/1482 ,  A61B2018/00386 ,  A61B2018/1407 ,  A61B2090/034 ,  A61B2090/036

    Abstract: Methods and apparatus employed in surgery involving making precise incisions in vessels of the body, particularly cardiac blood vessels in coronary revascularization procedures conducted on the stopped or beating heart are disclosed. Such incisions are created by applying an elongated electrosurgical cutting electrode to the outer surface of the vessel wall in substantially parallel alignment with the body vessel axis, the elongated electrosurgical cutting electrode having a predetermined cutting electrode length exceeding the cutting electrode width. RF energy is applied between the electrosurgical cutting electrode and the ground electrode at an energy level and for a duration sufficient to cut an elongated slit through the vessel wall where the elongated electrosurgical cutting electrode is applied to the surface of the vessel wall.

    Abstract translation: 公开了涉及在停止或跳动的心脏进行的冠状动脉血运重建手术中精确切开身体血管，特别是心脏血管的手术方法和装置。 这种切口是通过将细长的电外科切割电极以与体血管轴线基本平行对准的方式将细长的电外科切割电极施加到血管壁的外表面而形成的，细长的电外切割电极具有超过切割电极宽度的预定切割电极长度。 RF能量在电外科切割电极和接地电极之间以能量水平施加，持续时间足以切割通过血管壁的细长狭缝，其中细长的电外科切割电极被施加到血管壁的表面。

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