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    Methods and Systems for Treating Injured Cardiac Tissue
    3.
    发明申请
    Methods and Systems for Treating Injured Cardiac Tissue 审中-公开
    治疗受伤的心脏组织的方法和系统

    公开(公告)号：US20070042016A1

    公开(公告)日：2007-02-22

    申请号：US11426211

    申请日：2006-06-23

    申请人： Asha Nayak ,  James Keogh

    发明人： Asha Nayak ,  James Keogh

    IPC分类号： A61N1/30 ,  A61F2/00 ,  A61B1/32 ,  A61B17/08

    CPC分类号： A61L27/52 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00392 ,  A61L2400/16 ,  A61L2430/20 ,  A61M5/19 ,  A61N1/306 ,  A61N1/36017 ,  A61N1/362

    摘要： Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.

    摘要翻译： 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。

    Methods and systems for treating injured cardiac tissue
    6.
    发明申请
    Methods and systems for treating injured cardiac tissue 审中-公开
    治疗受伤心脏组织的方法和系统

    公开(公告)号：US20070093748A1

    公开(公告)日：2007-04-26

    申请号：US11643359

    申请日：2006-12-20

    申请人： Asha Nayak ,  James Keogh

    发明人： Asha Nayak ,  James Keogh

    IPC分类号： A61M31/00 ,  A61M37/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2017/0243 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00392 ,  A61N1/306 ,  A61N1/325 ,  A61N1/36014

    摘要： Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.

    摘要翻译： 公开了通过递送向心脏组织提供结构支持的组合物来治疗心脏组织损伤的方法和系统。 该组合物通过提供结合组织或组织结构加强组织结合生物疗法来防止室重塑。 结构上增强的组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。 公开了许多组合物，包括多组分物质如自体血小板凝胶和其它物质。 所公开的组合物可以含有添加剂以增强/增强注射的期望效果。

    Devices and Methods for Injection of Multiple-Component Therapies
    8.
    发明申请
    Devices and Methods for Injection of Multiple-Component Therapies 有权
    用于注射多组分疗法的装置和方法

    公开(公告)号：US20080161772A1

    公开(公告)日：2008-07-03

    申请号：US11969094

    申请日：2008-01-03

    申请人： Asha Nayak ,  Mario Maciel

    发明人： Asha Nayak ,  Mario Maciel

    IPC分类号： A61M5/19

    CPC分类号： A61M5/19 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00495 ,  A61B2018/00392 ,  A61M5/1782 ,  A61M5/204 ,  A61M5/284 ,  A61M5/3137 ,  A61M5/32 ,  A61M5/3294 ,  A61M5/3295 ,  A61M5/44 ,  A61M5/445 ,  A61M5/46 ,  A61M2005/3128 ,  A61M2005/3201 ,  A61M2205/3606 ,  A61M2205/3626 ,  A61M2205/3633 ,  A61M2205/3646

    摘要： Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes) attached to biaxial or coaxial injection cannula(s) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula(s). In some embodiments, the injector devices of the present invention may include a first set of finger grips at a first location and a second set of finger grips at a second location. Also, in some embodiments, the injector devices of the present invention may include depth slops for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the present invention may include refill manifolds with attached syringes or other reservoirs containing the component substances to facilitate refilling of the injectors.

    摘要翻译： 用于将人体或动物受试者注射或以其他方式递送多组分疗法的装置和方法。 具有连接到双轴或同轴注射套管的注射器（例如，注射器）的装置被用于递送特定治疗的多个部件，使得那些部件在离开注射套管之前或之后不久就组合。 在一些实施例中，本发明的注射器装置可以包括在第一位置处的第一组手指夹具和在第二位置处的第二组手指夹具。 而且，在一些实施例中，本发明的注射器装置可以包括用于控制组织内深度的深度斜率，治疗物质在其内被输送。 此外，在一些实施例中，本发明的注射器装置可以包括具有连接的注射器的补充歧管或包含组分物质的其它储存器，以便于重新注入喷射器。

    Patch for treating a septal defect
    9.
    发明申请
    Patch for treating a septal defect 审中-公开
    补片治疗间隔缺损

    公开(公告)号：US20060106420A1

    公开(公告)日：2006-05-18

    申请号：US10988462

    申请日：2004-11-12

    申请人： Mark Dolan ,  Asha Nayak

    发明人： Mark Dolan ,  Asha Nayak

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B17/064 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00615 ,  A61B2017/0641

    摘要： A system for treating a septal defect comprises a treatment device slidably received within a catheter. The device includes a patch attached to a support. The support has a body segment and a plurality of leg segments that self-expand radially outward as the device is released from the catheter. A method for treating a septal defect comprises delivering the treatment device in the catheter proximate a septal defect. The device is slid in a distal direction to release a portion of each leg segment from the catheter, the leg segments partially expanded radially outward. The leg segments are placed in contact with tissue surrounding the septal defect. The device is slid farther until the leg segments are fully released from the catheter and fully expanded, thereby implanting a distal portion of each leg segment in tissue surrounding the septal defect and positioning the patch against the septal defect.

    摘要翻译： 用于治疗间隔缺损的系统包括可滑动地容纳在导管内的治疗装置。 该装置包括附接到支撑件的贴片。 该支撑件具有主体段和多个腿段，当该装置从该导管释放时，该腿段自身径向向外扩张。 用于治疗间隔缺损的方法包括将治疗装置输送到靠近隔膜缺损的导管中。 该装置沿远端方向滑动以从导管释放每个腿段的一部分，腿段部分地径向向外扩张。 腿部段与隔膜缺损周围的组织接触。 该装置滑动得更远，直到腿部段从导管完全释放并完全膨胀，从而将每个腿段的远端部分植入围绕隔膜缺损的组织中，并将补片定位在隔膜缺损处。

    Cardiovascular defect patch device and method
    10.
    发明申请
    Cardiovascular defect patch device and method 审中-公开
    心血管缺损补片装置及方法

    公开(公告)号：US20050256532A1

    公开(公告)日：2005-11-17

    申请号：US10845439

    申请日：2004-05-12

    申请人： Asha Nayak ,  Sean Saint ,  Terry Guinan ,  Ronan Thornton ,  Patrick Hanley ,  Hilda Mulvihill

    发明人： Asha Nayak ,  Sean Saint ,  Terry Guinan ,  Ronan Thornton ,  Patrick Hanley ,  Hilda Mulvihill

    IPC分类号： A61B17/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/04

    CPC分类号： A61B17/0057 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/0061

    摘要： The present invention provides a defect patch device and method that patches a defect in the heart or other cardiovascular tissue. One aspect provides a PFO closure device and method that patches a PFO in the right atrium without the device extending through the PFO into the left atrium. The patch device includes a patch and a heart tissue engaging member for attaching the device over the defect. A deployment device and method includes a device positioner to advance the device out of a catheter and to position the device over the defect to attach the device to the tissue around the defect. The positioner may include a device expander or opener that opens the device for deployment.

    摘要翻译： 本发明提供一种补片在心脏或其他心血管组织中的缺陷的缺陷补丁装置和方法。 一个方面提供了一种PFO闭合装置和方法，其在右心房中修补PFO，而不将装置延伸穿过PFO进入左心房。 补片装置包括补片和心脏组织接合构件，用于将装置附接在缺陷上。 部署装置和方法包括：装置定位器，用于将装置推出导管并将装置定位在缺陷上以将装置附接到缺陷周围的组织。 定位器可以包括打开用于部署的设备的设备扩展器或开启器。