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    1,1 '-[[(SUBSTITUTED ALKYL)IMINO]BIS(ALKYLENE)]BIS-FERROCENES AND THEIR USE IN I ELECTROCHEMICAL ASSAYS BY LABELLING SUBSTRATES OF INTEREST
    3.
    发明申请
    1,1 '-[[(SUBSTITUTED ALKYL)IMINO]BIS(ALKYLENE)]BIS-FERROCENES AND THEIR USE IN I ELECTROCHEMICAL ASSAYS BY LABELLING SUBSTRATES OF INTEREST 审中-公开
    1,1' - [[（取代的烷基）亚胺基]双（双（亚烷基）]双岐杆菌及其在I电子测定中的用途标记基质

    公开(公告)号：US20150293107A1

    公开(公告)日：2015-10-15

    申请号：US14410296

    申请日：2013-06-21

    Applicant: Atlas Genetics Limited

    Inventor： Barrie MARSH ,  David PEARCE ,  Christopher FROST

    IPC: G01N33/58 ,  C12Q1/68 ,  C07F17/02

    CPC classification number: G01N33/58 ,  C07F17/02 ,  C12Q1/6816 ,  C12Q2563/113

    Abstract: Compounds of general formula I wherein Fc and Fc′ may be the same or different and are substituted ferrocenyl moieties having at least one ring substituent selected from sulfur-containing groups, phosphorus-containing groups, iodo, chloro, silyl, fluoroalkyl groups containing two or more fluorine atoms, heteroaryl, substituted phenyl, and cyano, wherein if present as sole substituent the cyano group is located on the proximal cyclopentadienyl ring; X is a spacer, Y is a spacer, Z is a spacer; and R is a linker group. Compound I may be used to make labelled substrates, functionalised compounds for making labelled substrates and may be used as labels in an electrochemical assay.

    Abstract translation: 通式I的化合物，其中Fc和Fc'可以相同或不同，并且是具有至少一个选自含硫基团，含磷基团，碘，氯，甲硅烷基，含有两个或多个的氟代烷基的环取代基的取代的二茂铁基部分 更多的氟原子，杂芳基，取代的苯基和氰基，其中如果作为唯一取代基存在，则氰基位于近端环戊二烯基环上; X是间隔物，Y是间隔基，Z是间隔基; 并且R是连接基团。 化合物I可以用于制备标记的底物，用于制备标记的底物的官能化化合物，并且可以在电化学测定中用作标记。

    Instrument for performing a diagnostic test on a fluidic cartridge
    5.
    发明授权
    Instrument for performing a diagnostic test on a fluidic cartridge 有权

    公开(公告)号：US10751719B2

    公开(公告)日：2020-08-25

    申请号：US15547786

    申请日：2016-02-02

    Applicant: Atlas Genetics Limited

    Inventor： Ben Arlett ,  Tom Edwards

    IPC: B01L3/00 ,  G01N35/10 ,  G01N35/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: A cartridge reader is configured to carry out a diagnostic test on a fluid sample contained within a fluidic cartridge. The cartridge comprises first, second and third collapsible blisters containing at least one reagent for use in the diagnostic test. The cartridge reader comprises an upper clamp, occupying a fixed position relative to the reader and a lower clamp, movable relative to the upper clamp, and wherein the upper clamp and the lower clamp are configured to receive and hold a fluidic cartridge therebetween. First, second and third blister actuators are mounted on the upper clamp, for aligning with first, second and third collapsible blisters of a fluidic cartridge inserted into the reader. The first, second and third blister actuators are movable relative to the upper clamp, between a first position in which the blister actuators are spaced apart from the collapsible blisters comprised on the fluidic cartridge received between the upper and lower clamps, and a second position in which the blister actuators depress the collapsible blisters, thereby collapsing the blisters and ejecting the reagents contained therein into a channel in the microfluidic cartridge.

    Detection method for Neisseria gonorrhoeae
    6.
    发明授权
    Detection method for Neisseria gonorrhoeae 有权

    公开(公告)号：US10519514B2

    公开(公告)日：2019-12-31

    申请号：US15511893

    申请日：2015-09-17

    Applicant: Atlas Genetics Limited

    Inventor： Danny Filer ,  Claire Ferrao ,  Sharon Chadwick

    IPC: C12Q1/68 ,  C12Q1/689

    Abstract: A method of detecting the presence of Neisseria gonorrhoeae in a sample. The method involves detecting a first target sequence taken from the NGO1642 gene and/or a second target sequence taken from the NGO1012 gene. The method may involve a step of amplifying the target sequence, and may involve hybridising the target sequence to a nucleic acid probe and identifying hybridisation. The method may involve simultaneous detection of other target sequences, e.g. from other pathogens.

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