公开(公告)号：US09961142B2

公开(公告)日：2018-05-01

申请号：US13818360

申请日：2012-02-15

Applicant: Hui Li ,  Xianxia Huang ,  Hanxu Hou ,  Tai Zhou ,  Bing Zhu ,  Changmin Chen ,  Jingbang Zhou

Inventor： Hui Li ,  Xianxia Huang ,  Hanxu Hou ,  Tai Zhou ,  Bing Zhu ,  Changmin Chen ,  Jingbang Zhou

IPC: H04L29/08 ,  H03M13/15 ,  H03M13/03 ,  G06F11/10

CPC classification number: H04L67/1097 ,  G06F11/1092 ,  H03M13/033 ,  H03M13/1515 ,  H04L67/1095

Abstract: A method, device and system disclosed used in storage technique, comprising: splitting a file of size M into k blocks, that is to say, each block is of size M/k; issuing the above k blocks across k different storage nodes in the distributed network storage system in a distributed manner; using the k blocks, constructing n−k independent blocks via linear coding method, and satisfying the property that any k of the n encoded blocks can be used to reconstruct the original data in the file, which means the linear coding method is a kind of Maximum-Distance Separable (MDS) code; distribute the n−k encoded blocks to the rest n−k different storage codes in the distributed network storage systems.

公开(公告)号：US20140342994A1

公开(公告)日：2014-11-20

申请号：US14344289

申请日：2011-09-16

Applicant: Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

Inventor： Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

IPC: A61K38/17 ,  A61K45/06 ,  C07K14/47

CPC classification number: A61K38/1761 ,  A61K38/00 ,  A61K45/06 ,  C07K14/47 ,  C07K14/4747 ,  C07K14/52 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K2319/21 ,  C07K2319/33 ,  C12N15/62 ,  C12N15/63

Abstract: Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

Abstract translation: 提供了包含循环形式的TRAIL的融合蛋白，并且融合蛋白包含位于置换形式的N末端和/或C末端的循环形式的TRAIL和寡肽。 寡肽含有由3-10组氨酸组成的重复序列。 从N末端到C末端的循环形式的TRAIL的组分是：（a）TRAIL的氨基酸135-281，（b）接头，和（c）TRAIL或氨基酸的氨基酸121-135 TRAIL的114-135或TRAIL的氨基酸95-135或含有TRAIL的第121-135位氨基酸的TRAIL的任何氨基酸95-135的片段。 还提供了通过使用融合蛋白治疗癌症的方法。

公开(公告)号：US20140206025A1

公开(公告)日：2014-07-24

申请号：US14240311

申请日：2011-08-30

Applicant: Shifang Yang ,  Junsheng Cui ,  Peng Wei ,  Xiangjun Zheng ,  Bing Zhu

Inventor： Shifang Yang ,  Junsheng Cui ,  Peng Wei ,  Xiangjun Zheng ,  Bing Zhu

IPC: G01N33/50

CPC classification number: G01N33/5091 ,  G01N33/57484 ,  G01N2333/904 ,  G01N2333/91188 ,  G01N2800/52

Abstract: The present invention relates to a method for early evaluation of clinical efficacy of antitumor intervention measure, comprising evaluating the efficacy of the antitumor intervention measure by assaying whether the content of a tumor-damaging biomarker(s) in the blood of a patient having tumor rises as compared to the baseline level before treatment within a time window after the patients receives at least one antitumor intervention measure. In preferable embodiments, the tumor-damaging biomarker(s) is selected from a group consisting of Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH); said tumor is multiple myeloma; said antitumor intervention measure is the administration of CPT alone or the administration of CPT in combination with thalidomide.

Abstract translation: 本发明涉及一种用于早期评估抗肿瘤干预措施的临床疗效的方法，包括通过测定患有肿瘤的患者的血液中的肿瘤损伤性生物标志物的含量是否上升来评估抗肿瘤干预措施的功效 与患者接受至少一种抗肿瘤干预措施后的时间窗内治疗前的基线水平相比。 在优选的实施方案中，肿瘤破坏性生物标志物选自丙氨酸氨基转移酶（ALT），天冬氨酸转氨酶（AST），乳酸脱氢酶（LDH）; 所述肿瘤是多发性骨髓瘤; 所述抗肿瘤干预措施是单独使用CPT或与沙利度胺组合使用CPT。

公开(公告)号：US08521267B1

公开(公告)日：2013-08-27

申请号：US11771660

申请日：2007-06-29

Applicant: Laleh Jalali ,  Jay Snell ,  Elizabeth Bacon ,  Katie Hoberman ,  Bing Zhu

Inventor： Laleh Jalali ,  Jay Snell ,  Elizabeth Bacon ,  Katie Hoberman ,  Bing Zhu

IPC: A61B5/0472

CPC classification number: A61B5/0472 ,  A61B5/0022 ,  A61B5/0031 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/36585 ,  G06F19/00 ,  G16H40/63

Abstract: A method and system are provided for trending a coronary burden such as an ischemic burden or acute myocardial infarction (AMI) for a patient. Trending provides obtaining cardiac data over a period of time, identifying the onset and the termination of coronary episodes based on a ST segment variation within the cardiac data, recording coronary burden information, and presenting the coronary burden information to a user. The coronary burden information may include the number of coronary episodes occurring over a period of time, the time duration of the coronary episodes, and the maximum ST segment variations for the coronary episodes that occur over a period of time.

Abstract translation: 提供了一种方法和系统，用于对患者的冠状动脉负荷如缺血负担或急性心肌梗塞（AMI）进行趋势。 趋势提供在一段时间内获得心脏数据，基于心脏数据内的ST段变化识别冠状动脉发作的发作和终止，记录冠状动脉负荷信息，以及向使用者呈现冠状动脉负荷信息。 冠状动脉负荷信息可以包括在一段时间内发生的冠状动脉发作次数，冠状动脉发作的持续时间以及在一段时间内发生的冠状动脉发作的最大ST段变化。

公开(公告)号：US08352235B1

公开(公告)日：2013-01-08

申请号：US11966602

申请日：2007-12-28

Applicant: Tsair-Chin Lin ,  Bing Zhu ,  Platon Beletsky

Inventor： Tsair-Chin Lin ,  Bing Zhu ,  Platon Beletsky

IPC: G06G7/54 ,  G06F17/50 ,  G06F9/455

CPC classification number: G06F17/5036 ,  G06F17/5022 ,  G06F2217/78

Abstract: A method for modeling power management in an integrated circuit (IC) includes: specifying a circuit design and a power architecture for the IC, the power architecture including a plurality of power domains for specifying power levels in different portions of the IC; determining an emulation module for the IC by including one or more hardware elements for modeling the power architecture in the emulation module; and using the emulation module to simulate changing power levels in one or more power domains of the IC including a power shutoff in at least one power domain.

Abstract translation: 一种用于对集成电路（IC）中的功率管理进行建模的方法包括：指定IC的电路设计和电源架构，所述电源架构包括用于指定所述IC的不同部分中的功率电平的多个功率域; 通过包括用于对仿真模块中的电力架构进行建模的一个或多个硬件元件来确定IC的仿真模块; 以及使用所述仿真模块来模拟所述IC的一个或多个功率域中的变化功率水平，包括在至少一个功率域中的功率切断。

公开(公告)号：US08108194B2

公开(公告)日：2012-01-31

申请号：US12346004

申请日：2008-12-30

Applicant: Bing Zhu ,  Tsair-Chin Lin ,  Tung-sun Tung ,  Jingbo Gao

Inventor： Bing Zhu ,  Tsair-Chin Lin ,  Tung-sun Tung ,  Jingbo Gao

IPC: G06F17/50 ,  G06F9/455

CPC classification number: G06F17/5027 ,  G06F2217/78

Abstract: A method of analyzing power consumption for a DUT (device under test) that includes an integrated circuit or an electronic system includes: providing emulation data for states of the DUT in one or more time windows; determining operational mode values from the emulation data and a selection of operational modes that characterize circuit behavior in the one or more time windows; dividing each time window into one or more segments based on at least one power criterion; determining power-activity values for the one or more segments; determining power-consumption values for the one or more segments from the power-activity values; using the power-activity values and the power-consumption values to determine relative power activity across the one or more segments and adjusting the one or more segments to target high power activity over operational modes in the one or more time windows; and saving one or more values for power activity of the DUT in a computer-readable medium.

Abstract translation: 一种分析包括集成电路或电子系统的DUT（被测设备）的功耗的方法包括：在一个或多个时间窗口中提供DUT的状态的仿真数据; 从所述仿真数据确定操作模式值，以及表征所述一个或多个时间窗口中的电路行为的操作模式的选择; 基于至少一个功率标准将每个时间窗分成一个或多个片段; 确定所述一个或多个段的功率活动值; 从所述功率活动值确定所述一个或多个片段的功耗值; 使用功率活动值和功率消耗值来确定跨越所述一个或多个段的相对功率活动并且调整所述一个或多个段以在所述一个或多个时间窗中的操作模式为目标高功率活动; 并且在计算机可读介质中保存DUT的功率活动的一个或多个值。

公开(公告)号：US20110245699A1

公开(公告)日：2011-10-06

申请号：US13049805

申请日：2011-03-16

Applicant: Jay Snell ,  Bing Zhu ,  Katie Hoberman ,  Harish Krishnaswamy

Inventor： Jay Snell ,  Bing Zhu ,  Katie Hoberman ,  Harish Krishnaswamy

IPC: A61B5/0452

CPC classification number: A61B5/0452 ,  A61B5/7264

Abstract: Cardiac activity is sensed over a plurality of heart beats defining a beat set. For each beat in the set, it is determined whether the beat is a non-classified beat (e.g., paced beat, a beat outside of a specified heart rate range or a PVC), or a classified beat. For each classified beat, it is determined whether the beat is a non-detect beat, a minor beat or a major beat. Counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats are maintained. The beat set is declared to be one of a non-classified set, a major set, a minor set or a non-detect set based on the relative counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats. Over a period of time, counts of beat-set types are maintained and entry into and exit from ST episodes are determined based on these beat-set counts.

Abstract translation: 在定义拍子组的多个心跳上感测到心脏活动。 对于集合中的每个节拍，确定节拍是否是非分类节拍（例如，节奏拍子，指定的心率范围或PVC之外的节拍）或分类节拍。 对于每个分类的节拍，确定节拍是否是非检测节拍，小节奏或主要节拍。 维持分类节拍，非分类节拍，主要节拍，次要节拍和非检测节拍的数量。 基于分类节拍，非分类节拍，主要节拍，次要节拍和非节奏组合的相对计数，节拍组被宣布为非分类组，主要组，未成年组或未检测组之一 检测节拍 在一段时间内，基于这些节拍设置计算确定节拍类型的计数，并且进入和退出ST剧集。

公开(公告)号：US07930017B1

公开(公告)日：2011-04-19

申请号：US11753759

申请日：2007-05-25

Applicant: Eric S. Fain ,  Jay Snell ,  Katie Hoberman ,  Laleh Jalali ,  Bing Zhu ,  Jeffery D. Snell

Inventor： Eric S. Fain ,  Jay Snell ,  Katie Hoberman ,  Laleh Jalali ,  Bing Zhu ,  Jeffery D. Snell

IPC: A61B5/04

CPC classification number: A61B5/0402 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/6846

Abstract: A method and system are provided for trending variation in coronary burden across multiple heart rate ranges. The method and system include obtaining cardiac signals having a segment of interest over a period of time where each cardiac signal has an associated heart rate that falls within at least one heart rate range. Segment variations of the segment of interest are determined and grouped based on the associated heart rates to produce distributions of segment variations that are associated with the heart rate ranges. Trending information is produced by automatically comparing the distributions of segment variations between different heart rate ranges.

Abstract translation: 提供了一种方法和系统，用于跨越多个心率范围的冠状动脉负荷的趋势变化。 所述方法和系统包括在一段时间内获得具有感兴趣区段的心脏信号，其中每个心脏信号具有落入至少一个心率范围内的相关心率。 基于相关的心率来确定和分组感兴趣区段的区段变化，以产生与心率范围相关联的区段变化的分布。 通过自动比较不同心率范围之间的段变化的分布来产生趋势信息。

公开(公告)号：US20100158930A1

公开(公告)日：2010-06-24

申请号：US12446382

申请日：2007-10-19

Applicant: Bing Zhu ,  Shifang Yang ,  Junsheng Cui

Inventor： Bing Zhu ,  Shifang Yang ,  Junsheng Cui

IPC: A61K39/00 ,  C07H21/00 ,  A61P37/04 ,  A61P31/12 ,  A61P31/14

CPC classification number: A61K39/12 ,  A61K2039/585 ,  A61K2039/6031 ,  C07K14/005 ,  C07K14/4725 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

Abstract: The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.

Abstract translation: 本发明提供了包含免疫刺激多肽和人乳头瘤病毒的突变E7蛋白的融合蛋白。 本发明还提供了编码融合蛋白的基因，含有该基因的表达载体，包含该融合蛋白的药物组合物，通过使用融合蛋白治疗或预防人乳头状瘤病毒相关疾病的方法以及融合蛋白的用途 制备用于治疗或预防人乳头状瘤病毒相关疾病的药物。

公开(公告)号：US07725171B1

公开(公告)日：2010-05-25

申请号：US11848606

申请日：2007-08-31

Applicant: Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Katie Hoberman ,  Elizabeth Bacon

Inventor： Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Katie Hoberman ,  Elizabeth Bacon

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61N1/365

Abstract: A method and system are provided for tracking ST shift data. The system includes an implantable medical device having an input configured to receive cardiac signals. Each cardiac signal has an associated heart rate and includes a segment of interest. The implantable medical device further includes a processor configured to determine segment variations of the segment of interest in the cardiac signals. The processor determines a heart rate associated with each of the segment variations with each heart rate falling within a corresponding heart rate range. The implantable medical device also includes a memory configured to store a group of histograms for a corresponding group of heart rate ranges. The histograms store distributions for the segment variations within corresponding heart rate ranges.

Abstract translation: 提供了一种跟踪ST移位数据的方法和系统。 该系统包括具有被配置为接收心脏信号的输入的可植入医疗装置。 每个心脏信号具有相关的心率并且包括感兴趣的部分。 可植入医疗装置还包括被配置为确定心脏信号中感兴趣区段的区段变化的处理器。 每个心率落在对应的心率范围内，处理器确定与每个区段变化相关联的心率。 可植入医疗装置还包括被配置为存储用于相应心率范围组的一组直方图的存储器。 直方图存储在相应的心率范围内的段变化的分布。