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公开(公告)号：US20120269761A1
公开(公告)日：2012-10-25
申请号：US13428869
申请日：2012-03-23
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。
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公开(公告)号：US08912304B2
公开(公告)日：2014-12-16
申请号：US12600596
申请日：2008-05-16
IPC分类号： C08G63/02 , C08G63/668 , A61L27/54 , A61L27/52 , A61L27/58 , A61L27/38 , A61L27/16 , C08G63/21 , C08F283/00
CPC分类号： C08G63/668 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/604 , C08G63/21 , C08L33/02
摘要： The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
摘要翻译： 本发明提供本发明的多元醇基聚合物，材料，药物组合物以及制备和使用本发明的聚合物和材料的方法。 在本发明的某些方面，本发明的聚合物对应于下面描述的聚合物。 示例性的本发明聚合物包括使用与多元羧酸单元（例如柠檬酸，戊二酸或癸二酸）缩合的多元醇单元（例如木糖醇，甘露糖醇，山梨糖醇或麦芽糖醇）制备的那些聚合物。 本发明的聚合物可进一步衍生或修饰。 例如，可以通过向聚合物中加入甲基丙烯酸酯部分使聚合物可光交联。
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公开(公告)号：US20090047256A1
公开(公告)日：2009-02-19
申请号：US11623041
申请日：2007-01-12
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： A61K35/12 , C08G63/00 , C08G63/06 , C08G63/66 , C08G73/02 , A61K47/34 , A61N1/30 , A61K31/7088 , A61K31/715 , A61K38/02 , A61K35/00
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化的共聚物共聚。
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公开(公告)号：US20110297885A1
公开(公告)日：2011-12-08
申请号：US13147390
申请日：2010-02-04
CPC分类号： F26B9/10 , C10B53/02 , C10J3/466 , C10J2300/0903 , C10J2300/0916 , C10J2300/0926 , C10J2300/1659 , C10J2300/1665 , C10L5/361 , C10L5/363 , C10L5/44 , C10L9/083 , F26B3/286 , Y02B40/74 , Y02E50/10 , Y02E50/14 , Y02E50/15 , Y02E50/18 , Y02E50/30 , Y02P20/129
摘要： The invention is directed to a process to prepare a fuel or an intermediate to a fuel from residues as obtained in a palm oil process wherein shredded agricultural residue having a water content of between 40 and 75 wt % water is dried to obtain a dried agricultural residue having a water content of between 5 and 40 wt % and then is compacted into pellets, cubes, or small briquettes having a two dimensional size of between 5 and 1000 mm and a thickness of between 5 and 300 mm and a density of between 200 and 1200 kg/m3.
摘要翻译： 本发明涉及一种从棕榈油工艺中获得的残留物制备燃料或燃料中间体的方法，其中干燥含水量为40至75重量％的水的切碎的农业残余物以获得干燥的农业残留物 具有5至40重量％的含水量，然后压实成具有5至1000mm的二维尺寸和5至300mm之间的密度在200和200之间的颗粒，立方体或小团块 1200 kg / m3。
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公开(公告)号：US20090011486A1
公开(公告)日：2009-01-08
申请号：US11682139
申请日：2007-03-05
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： C12N11/08
CPC分类号： C08J9/0023 , C08G63/20 , C08G63/914 , C08J2201/024 , C08J2207/10 , C08J2367/00
摘要： The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and a population of cells to form elastic porous polymer scaffolds suitable for cell encapsulation and/or proliferation.
摘要翻译： 各方面的本发明提供了用于封装细胞的弹性聚合物组合物。 在各种实施方案中，通过多官能醇或醚和双官能或更高级酸的反应形成聚合物以形成预聚物，其在甘油和细胞群中存在下交联以形成弹性多孔 适用于细胞包封和/或增殖的聚合物支架。
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6.发明授权Method comprising contacting tissue with a cross-linkable polyester prepolymer 有权方法包括使组织与可交联聚酯预聚物接触公开(公告)号：US08691203B2
公开(公告)日：2014-04-08
申请号：US13428869
申请日：2012-03-23
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。
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公开(公告)号：US08143042B2
公开(公告)日：2012-03-27
申请号：US11623041
申请日：2007-01-12
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。
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公开(公告)号：US20110008277A1
公开(公告)日：2011-01-13
申请号：US12600596
申请日：2008-05-16
IPC分类号： A61K31/765 , C08G63/12
CPC分类号： C08G63/668 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/604 , C08G63/21 , C08L33/02
摘要： The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
摘要翻译： 本发明提供本发明的多元醇基聚合物，材料，药物组合物以及制备和使用本发明的聚合物和材料的方法。 在本发明的某些方面，本发明的聚合物对应于下面描述的聚合物。 示例性的本发明聚合物包括使用与多元羧酸单元（例如柠檬酸，戊二酸或癸二酸）缩合的多元醇单元（例如木糖醇，甘露糖醇，山梨糖醇或麦芽糖醇）制备的那些聚合物。 本发明的聚合物可进一步衍生或修饰。 例如，可以通过向聚合物中加入甲基丙烯酸酯部分使聚合物可光交联。
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公开(公告)号：US20100184873A1
公开(公告)日：2010-07-22
申请号：US12640298
申请日：2009-12-17
IPC分类号： C07C27/06
摘要： The invention pertains to a multi-stage process for the production of hydrocarbons from syngas comprising hydrogen and carbon monoxide, which comprises the steps of: a) providing a fresh syngas feed to a first stage Fischer-Tropsch reactor and allowing CO and hydrogen to convert into hydrocarbon products at a temperature in the range from 125 to 400° C. and a pressure in the range from 5 to 150 bar absolute, and a gaseous hourly space velocity in the range from 500 to 10000 Nl/l/h; b) feeding the effluent from the first stage reactor to a separation unit; c) removing a gasous effluent stream comprising hydrogen and CO from the separation unit; d) removing one or more other streams comprising hydrocarbon and/or water from the separation unit; e) conveying a first portion of the gaseous effluent stream to a second stage Fischer-Tropsch reactor and allowing CO and hydrogen to convert into hydrocarbon products in the second stage Fischer-Tropsch reactor at a temperature in the range from 125 to 400° C. and a pressure in the range from 5 to 150 bar absolute, and a gaseous hourly space velocity in the range from 500 to 10000 Nl/l/h, whereby the first stage Fischer-Tropsch reactor and the second stage Fischer-Tropsch reactor are separate reactors; f) feeding the effluent from the second stage Fischer-Tropsch reactor to the separation unit; g) removing a second portion of the gaseous effluent stream as off-gas.
摘要翻译： 本发明涉及用于从包含氢气和一氧化碳的合成气生产碳氢化合物的多级方法，其包括以下步骤：a）向新的第一阶段费 - 托反应器提供新的合成气进料并允许CO和氢转化 在125至400℃的温度和5至150巴绝对压力的范围内的气体产物，并且气时空速在500至10000Nl / l / h的范围内; b）将来自第一级反应器的流出物供给到分离单元; c）从分离单元中除去包含氢和CO的气体流出物流; d）从分离单元去除包含烃和/或水的一种或多种其它流; e）将第一部分气态流出物流输送到第二级费 - 托反应器，并允许CO和氢在第二级费 - 托反应器中在125-400℃的温度下转化成烃产物。 压力范围为5至150巴绝对压力，气时空速为500至10000Nl / l / h，其中第一级费 - 托反应器和第二级费 - 托反应器是分开的 反应堆 f）将来自第二级费 - 托反应器的流出物供给到分离单元; g）除去作为废气的气态流出物流的第二部分。
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