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54 条记录 (耗时 0.103 秒)

    Growth factor HTTER36
    6.
    发明授权
    Growth factor HTTER36 失效

    公开(公告)号：US6004780A

    公开(公告)日：1999-12-21

    申请号：US827336

    申请日：1997-03-26

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： A61K48/00 ,  C07K14/495 ,  C12N1/21 ,  C12N15/18 ,  C12N5/00 ,  C12N15/63

    CPC分类号： C07K14/495 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    Adrenergic receptor
    7.
    发明授权
    Adrenergic receptor 失效
    肾上腺素能受体

    公开(公告)号：US5994506A

    公开(公告)日：1999-11-30

    申请号：US30582

    申请日：1998-02-25

    申请人： Daniel R. Soppet ,  Yi Li ,  Mark D. Adams

    发明人： Daniel R. Soppet ,  Yi Li ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12

    CPC分类号： C07K14/70571 ,  C07K14/723 ,  A61K38/00 ,  C12N2799/026

    摘要： A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

    摘要翻译： 公开了人类肾上腺素能受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了肾上腺素能受体多肽的激动剂，其可以用于治疗性地刺激肾上腺素能受体和拮抗剂对抗这些肾上腺素能受体多肽的抑制剂及其用于拮抗肾上腺素能受体的用途。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。

    Human G-protein receptor HCEGH45
    8.
    发明授权
    Human G-protein receptor HCEGH45 失效
    人类G蛋白受体HCEGH45

    公开(公告)号：US5869632A

    公开(公告)日：1999-02-09

    申请号：US465976

    申请日：1995-06-06

    申请人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Daniel R. Soppet ,  Yi Li ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07K14/72 ,  C07K14/705 ,  A61K38/00

    摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人类G蛋白受体HCEGH45多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。 针对这种多肽的拮抗剂可以用于治疗PACAP过度分泌病症并产生药理学遗忘症模型，同时激动剂可用于治疗遗忘症和阿尔茨海默氏病。 还公开了用于检测受体核酸序列中的突变并检测衍生自宿主的样品中可溶形式的受体的诊断方法。

    GROWTH FACTOR HTTER36
    9.
    发明申请
    GROWTH FACTOR HTTER36 审中-公开
    增长因素HTTER36

    公开(公告)号：US20120016107A1

    公开(公告)日：2012-01-19

    申请号：US13008653

    申请日：2011-01-18

    申请人： Daniel R. Soppet ,  Haodong Li

    发明人： Daniel R. Soppet ,  Haodong Li

    IPC分类号： C07K16/18

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/495

    摘要： The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided are antibodies that bind HTTER36, including chimeric, humanized, and single chain antibodies.

    摘要翻译： 本发明公开了生长因子HTTER36（GDF3）多肽和编码这种多肽的多核苷酸。 还提供了结合HTTER36的抗体，包括嵌合，人源化和单链抗体。

    GROWTH FACTOR HTTER36
    10.
    发明申请
    GROWTH FACTOR HTTER36 审中-公开
    增长因素HTTER36

    公开(公告)号：US20110117095A1

    公开(公告)日：2011-05-19

    申请号：US12818854

    申请日：2010-06-18

    申请人： DANIEL R. SOPPET ,  HAODONG LI

    发明人： DANIEL R. SOPPET ,  HAODONG LI

    IPC分类号： A61K39/395 ,  A61P25/00 ,  A61P3/04

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/495

    摘要： The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include the diagnosis, prevention, and treatment of wasting disorders. Also disclosed are antagonists against such polypeptide and their therapeutic uses which include the diagnosis, prevention, and treatment of obesity and obesity-related disorders. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    摘要翻译： 本发明公开了生长因子HTTER36（GDF3）多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和包括诊断，预防和治疗消耗性疾病的多肽的治疗用途产生此类多肽的方法。 还公开了抗这种多肽及其治疗用途的拮抗剂，包括诊断，预防和治疗肥胖症和肥胖相关疾病。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。