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    Method and apparatus for reducing a stent
    1.
    发明申请
    Method and apparatus for reducing a stent 有权
    用于减少支架的方法和装置

    公开(公告)号：US20060265855A1

    公开(公告)日：2006-11-30

    申请号：US11137638

    申请日：2005-05-25

    Applicant: Eric Stenzel

    Inventor： Eric Stenzel

    IPC: B21D39/00

    CPC classification number: A61F2/82 ,  A61F2002/9522 ,  Y10T29/49913

    Abstract: A medical device crimping system comprises a crimper and a plurality of protective strips. The crimper defines a crimping iris, which has an open state and a closed state. In the open state the cross-sectional area of the crimping iris is greater than in the closed state. The plurality of protective strips extend longitudinally through the crimping iris. Each of the strips is radially offset from one another. The strips protect the stent from direct contact with the crimping blades of the crimper.

    Abstract translation: 医疗装置压接系统包括卷边器和多个保护条。 卷曲器定义了卷曲虹膜，其具有打开状态和闭合状态。 在打开状态下，卷曲虹膜的横截面面积大于关闭状态。 多个保护带纵向延伸通过卷曲虹膜。 每个条带彼此径向偏移。 条带保护支架免受卷边机的压接刀片的直接接触。

    Electrohydrodynamic coating fluid delivery apparatus and method
    3.
    发明申请
    Electrohydrodynamic coating fluid delivery apparatus and method 审中-公开

    公开(公告)号：US20070122563A1

    公开(公告)日：2007-05-31

    申请号：US11656504

    申请日：2007-01-23

    Applicant: Dennis Boulais ,  Eric Stenzel

    Inventor： Dennis Boulais ,  Eric Stenzel

    IPC: B05C5/00 ,  B05D3/00 ,  C04B41/00

    CPC classification number: B05B5/025 ,  A61L31/10 ,  A61L31/16 ,  B05B5/08 ,  B05B5/10 ,  B05B5/16

    Abstract: An apparatus and method for improved control of low viscosity fluid flow during electrohydrodynamic spray deposition of the fluid to coat small targets, such as medical devices like stents. The apparatus includes a target holder which applies a first electrical potential to a target, a coating fluid transporter such as a wick, a siphon tube or a siphon tube with a wick therein along which the coating fluid flows from a reservoir to a dispensing end of the transporter, and an electrode which applied a second electrical potential to the coating fluid sufficient to cause the coating fluid to be attracted from the dispensing end of the transporter toward the target. This provides a target coating apparatus with highly self-regulating coating fluid flow characteristics despite the low viscosity of the coating fluid, while producing highly consistent and uniform target coatings.

    Medical device having a lubricant
    5.
    发明申请
    Medical device having a lubricant 审中-公开
    具有润滑剂的医疗装置

    公开(公告)号：US20070078413A1

    公开(公告)日：2007-04-05

    申请号：US11210724

    申请日：2005-08-25

    Applicant: Eric Stenzel

    Inventor： Eric Stenzel

    IPC: A61M25/00 ,  A61M5/00 ,  A61M31/00 ,  A61M5/32

    CPC classification number: A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

    Abstract: A medical device includes a member, a coating, and a lubricant. In one embodiment, the coating includes a therapeutic agent. In one embodiment, the coating is disposed on at least a portion of the body and the lubricant is disposed on at least a portion of the coating. In one embodiment, the lubricant is formulated to provide an effective degree of lubricity between the coating and at least one of a surface of a package configured to receive at least a portion of the medical device, another portion of the medical device, a coating of another medical device, and an uncoated portion of another medical device. In one embodiment, the lubricant is soluble in at least one of water and a bodily fluid of a mammal. In one embodiment, the coating is formulated to release from the member when the medical device is placed within a body of a patient.

    Abstract translation: 医疗装置包括构件，涂层和润滑剂。 在一个实施方案中，涂层包括治疗剂。 在一个实施例中，涂层设置在主体的至少一部分上，润滑剂设置在涂层的至少一部分上。 在一个实施方案中，配制润滑剂以在涂层与包装的表面中的至少一个之间提供有效的润滑性，其被配置为接收医疗装置的至少一部分，医疗装置的另一部分，医疗装置的另一部分 另一医疗设备，以及另一医疗设备的未涂覆部分。 在一个实施方案中，润滑剂可溶于哺乳动物的水和体液中的至少一种。 在一个实施方案中，当医疗装置放置在患者体内时，涂层被配制成从构件释放。

    Coated medical device having an increased coating surface area
    7.
    发明申请
    Coated medical device having an increased coating surface area 审中-公开
    具有增加的涂层表面积的涂覆医疗装置

    公开(公告)号：US20060034884A1

    公开(公告)日：2006-02-16

    申请号：US10916109

    申请日：2004-08-10

    Applicant: Eric Stenzel

    Inventor： Eric Stenzel

    IPC: A61F13/00

    CPC classification number: A61F2/86 ,  A61F2/91 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L25/06

    Abstract: The present invention is directed to a coated medical device for delivering a biologically active agent to a body tissue such as a body lumen, said coated medical device having an increased coating surface area for adjusting the release rate of a biologically active agent, such as a drug, from the coating. The medical device has a coating comprising an outer surface having a surface area and capable of being in direct contact with the body tissue, and a plurality of indentations in the outer surface of the coating. The surface area of the coating outer surface is therefore greater than the surface area of the coating outer surface absent the indentations. The present invention is also directed to a method for making a medical device comprising forming a coating comprising a polymer and a biologically active agent on a surface of a medical device, wherein the coating comprises an outer surface capable of being in direct contact with body tissue, and increasing the surface area of the outer surface by forming indentations on the outer surface of the coating.

    Abstract translation: 本发明涉及一种用于将生物活性剂递送到诸如体腔的身体组织的涂覆医疗装置，所述涂覆的医疗装置具有增加的涂覆表面积，用于调节生物活性剂的释放速率，例如 药物，从涂层。 该医疗装置具有包括具有表面积并能够与身体组织直接接触的外表面的涂层，以及涂层的外表面中的多个凹陷。 因此，涂层外表面的表面积大于没有凹痕的涂层外表面的表面积。 本发明还涉及一种用于制造医疗装置的方法，包括在医疗装置的表面上形成包含聚合物和生物活性剂的涂层，其中所述涂层包括能够与身体组织直接接触的外表面 并且通过在涂层的外表面上形成凹陷来增加外表面的表面积。

    Method of improving the quality and performance of a coating on a coated medical device using a solvent to reflow the coating
    8.
    发明申请
    Method of improving the quality and performance of a coating on a coated medical device using a solvent to reflow the coating 审中-公开
    使用溶剂提高涂层医疗装置上涂层质量和性能的方法来回流涂层

    公开(公告)号：US20050112273A1

    公开(公告)日：2005-05-26

    申请号：US10973183

    申请日：2004-10-25

    Applicant: Eric Stenzel

    Inventor： Eric Stenzel

    IPC: A61L31/10 ,  A61L31/16 ,  A61F2/02

    CPC classification number: A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02

    Abstract: A method is provided for coating at least a portion of at least one medical device. The method includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and spraying, subsequent to the arranging of the polymer and the arranging of the bioactive agent, a solvent on the portion of the medical device. The method may further include selecting a composition of the solvent to achieve a desired agent release response profile for the medical device. A medical appliance is provided having a coating applied by a method that includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and subsequently spraying a solvent on the portion of the medical device. A method is provided for achieving a desired agent release response profile for a medical device by reflowing the coating with a solvent.

    Abstract translation: 提供了一种用于涂覆至少一个医疗装置的至少一部分的方法。 该方法包括在医疗装置的该部分上布置聚合物，将生物活性剂置于医疗装置的该部分上，以及在将聚合物的排列和生物活性剂的排列之后，在 医疗器械。 该方法还可以包括选择溶剂的组合物以实现医疗装置的期望的药剂释放反应曲线。 提供了一种医疗器具，其具有通过包括在医疗装置的部分上布置聚合物的方法施加的涂层，在医疗装置的该部分上布置生物活性剂，随后在医疗装置的该部分上喷涂溶剂。 提供了一种用于通过用溶剂回流涂层来获得用于医疗装置的期望的药剂释放反应曲线的方法。

    Method and apparatus for controlled delivery of active substance
    9.
    发明申请
    Method and apparatus for controlled delivery of active substance 有权
    活性物质的控制递送方法和装置

    公开(公告)号：US20050100582A1

    公开(公告)日：2005-05-12

    申请号：US10701455

    申请日：2003-11-06

    Applicant: Eric Stenzel

    Inventor： Eric Stenzel

    IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/02 ,  A61F2/06

    CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/61 ,  A61L2300/62

    Abstract: The invention relates to a method and device for coating a device with time-release drugs by providing a plurality of micro coated pellets having different release rates on the surface of the medical device structure, e.g., a stent. Organizing the micro pellets with different release rates on the structure can result in the structure having a plurality of release regions with varying release profiles.

    Abstract translation: 本发明涉及一种通过在医疗装置结构例如支架的表面上提供具有不同释放速率的多个微涂层丸剂来涂覆具有时间释放药物的装置的方法和装置。 在结构上以不同的释放速率组织微丸可导致结构具有多个具有变化释放曲线的释放区。

    Method and apparatus for selective ablation of coatings from medical devices
    10.
    发明申请
    Method and apparatus for selective ablation of coatings from medical devices 审中-公开
    从医疗器械选择性消融涂层的方法和装置

    公开(公告)号：US20050087520A1

    公开(公告)日：2005-04-28

    申请号：US10694050

    申请日：2003-10-28

    Applicant: Lixiao Wang ,  Eric Stenzel

    Inventor： Lixiao Wang ,  Eric Stenzel

    IPC: A61F2/00 ,  A61F2/82 ,  B23K26/08 ,  B23K26/36 ,  B23K26/38

    CPC classification number: B23K26/0823 ,  A61F2/0077 ,  A61F2/82 ,  A61F2250/0067 ,  B23K26/361

    Abstract: An apparatus and method for selective ablation of therapeutic coating material from the surfaces of generally tubular medical devices, such as stents or guide wires, is provided. The medical device is rotated about its longitudinal axis, and a laser is operated in coordination with the rotational motion of the medical device to ablate a selected portion of the coating from the device, such as a portion of undesired coating. In a further embodiment, laser ablation of the coating on a medical device is conducted to reduce the amount of coating material on the device to a desired target amount of coating.

    Abstract translation: 提供了一种用于从一般管状的医疗装置（例如支架或引导线）的表面选择性地消融治疗性涂层材料的装置和方法。 医疗装置围绕其纵向轴线旋转，并且与医疗装置的旋转运动协调地操作激光器以从装置（例如不期望的涂层的一部分）烧蚀涂层的选定部分。 在另一实施例中，进行医疗装置上的涂层的激光烧蚀以将装置上的涂层材料的量减少到期望的目标涂层量。

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