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公开(公告)号:US08853234B2
公开(公告)日:2014-10-07
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: C07D498/06 , C07D498/16 , C07D471/14 , C07D513/14
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US08575177B2
公开(公告)日:2013-11-05
申请号:US12946759
申请日:2010-11-15
申请人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
发明人: Mustapha Haddach , Joe A. Tran , Fabrice Pierre , Collin F. Regan , Nicholas B. Raffaele , Suchitra Ravula , David M. Ryckman
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06
摘要: The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula:
摘要翻译: 本发明提供抑制蛋白激酶CK2活性的化合物(CK2活性)以及含有这些化合物的组合物。 这些化合物和组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症,疼痛和某些免疫学疾病,并具有以下通式:
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公开(公告)号:US20110218184A1
公开(公告)日:2011-09-08
申请号:US13043956
申请日:2011-03-09
申请人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo NAGASAWA , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A61K31/497 , C07D513/14 , A61K31/496 , A61K31/5377 , C07D471/14 , A61K31/4375 , A61K31/551 , C07D417/14 , A61K31/541 , A61P35/00 , C12N5/071
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US07928100B2
公开(公告)日:2011-04-19
申请号:US12245619
申请日:2008-10-03
申请人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
发明人: Johnny Yasuo Nagasawa , Fabrice Pierre , Mustapha Haddach , Michael Schwaebe , Levan Darjania , Jeffrey P. Whitten
IPC分类号: A01N43/62 , A61K31/55 , C07D243/08
CPC分类号: C07D513/14 , C07D471/14 , C07D498/06 , C07D498/16
摘要: The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
摘要翻译: 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的新型喹诺酮化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其制备和使用方法。
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公开(公告)号:US20110071136A1
公开(公告)日:2011-03-24
申请号:US12883688
申请日:2010-09-16
申请人: Mustapha HADDACH , Fabrice PIERRE
发明人: Mustapha HADDACH , Fabrice PIERRE
IPC分类号: A61K31/4365 , C12N5/09 , C07D495/04 , C07D471/04 , C07D491/048 , C07D221/12 , C07D221/06 , C07D487/04 , C07D513/04 , A61K31/4375 , A61K31/4355 , A61K31/473 , A61K31/437 , A61K31/4985 , A61K31/55 , A61K31/519 , A61P35/00 , A61P31/00 , A61P33/02 , A61P31/18 , A61P31/22 , A61P31/14 , A61P31/16 , A61P33/12 , A61P29/00 , A61P27/02
CPC分类号: C07D495/04 , C07D221/10 , C07D221/16 , C07D471/04 , C07D487/04 , C07D491/048 , C07D513/04
摘要: The invention provides compounds that inhibit CK2 and/or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.
摘要翻译: 本发明提供抑制CK2和/或Pim激酶的化合物和含有这些化合物的组合物。 这些三环化合物和含有它们的组合物可用于治疗增殖性疾病如癌症,以及其它激酶相关病症,包括炎症,疼痛,致病性感染和某些免疫学疾病。
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公开(公告)号:US20090093465A1
公开(公告)日:2009-04-09
申请号:US12201892
申请日:2008-08-29
申请人: Fabrice PIERRE , Mustapha HADDACH
发明人: Fabrice PIERRE , Mustapha HADDACH
IPC分类号: A61K31/551 , C07D471/04 , A61K31/4375 , C07D513/04 , C12N9/12 , C12N5/06 , C12Q1/48 , A61K31/437 , A61K31/519
CPC分类号: C12Q1/485 , C07D471/04 , C07D513/04 , G01N2333/91215 , G01N2500/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖和调节蛋白激酶活性。 本发明的分子可以调节酪蛋白激酶(CK)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US08168651B2
公开(公告)日:2012-05-01
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/44 , C07D471/02
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号:US07834180B2
公开(公告)日:2010-11-16
申请号:US12274302
申请日:2008-11-19
IPC分类号: C07D513/22 , C07D487/22 , C07D471/22 , C07D471/14 , C07D498/22 , A61P35/00 , A61P43/00
CPC分类号: C07D471/14 , C07D495/14 , C07D513/14
摘要: Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1, W, X, B′, R and n are as defined herein.
摘要翻译: 具有式1的化合物是通过在非亲核性碱存在下使式(6A)化合物与式(7)化合物或其互变异构体接触来制备的,其中V,A,Z,L, W,X,B',R和n如本文所定义。
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公开(公告)号:US20100004298A1
公开(公告)日:2010-01-07
申请号:US12557835
申请日:2009-09-11
申请人: Qing Dong , Fabrice Pierre , Jianqiang Wang
发明人: Qing Dong , Fabrice Pierre , Jianqiang Wang
IPC分类号: A61K31/426 , C07D277/18 , C12N9/99 , A61P29/00 , A61P37/00 , A61P25/00 , A61P31/12 , A61P19/08 , C07D285/08 , C07D285/12 , C07D271/06 , C07D249/14 , C07D263/02 , A61K31/433 , A61K31/4245 , A61K31/421 , A61K31/4196
CPC分类号: C07D271/07 , C07D249/14 , C07D263/48 , C07D277/42 , C07D277/56 , C07D285/08 , C07D417/04 , C07D417/10 , C07D417/12
摘要: Provided are 5-membered heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
摘要翻译: 提供的是5元杂环的p38激酶,包括p38alpha和p38beta激酶,抑制剂。 还提供了含有这些化合物的药物组合物。 还提供了使用化合物和组合物的方法,包括治疗,预防或改善p38激酶介导的疾病和病症(包括但不限于炎性疾病和病症)的一种或多种症状的方法。
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公开(公告)号:US20090239859A1
公开(公告)日:2009-09-24
申请号:US12396084
申请日:2009-03-02
IPC分类号: A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号: C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译: 本发明部分地涉及具有某些生物活性的分子,包括但不限于抑制细胞增殖,调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶(Flt)活性。 本发明还部分涉及使用这种分子的方法。
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