公开(公告)号：US4367454A

公开(公告)日：1983-01-04

申请号：US350320

申请日：1982-02-19

Applicant: Frank Modica

Inventor： Frank Modica

IPC: B60J7/185 ,  B60R25/00 ,  B60R25/10 ,  B60J7/10

CPC classification number: B60J7/194 ,  B60R25/00 ,  B60R25/1001 ,  Y10T292/1028

Abstract: An alarm and locking device for deterring theft of removable vehicle rooftops. An alarm is sounded if an unauthorized attempt to remove a rooftop is made, while successful removal of the rooftop is prevented by a locking mechanism.

Abstract translation: 一种用于防止可拆卸车顶屋顶被盗窃的报警和锁定装置。 如果未经授权的企图拆除屋顶，则会发出警报，同时通过锁定机构防止屋顶的成功拆卸。

公开(公告)号：US20210348109A1

公开(公告)日：2021-11-11

申请号：US17317797

申请日：2021-05-11

Applicant: Frank MODICA ,  Nicholas CHOPAS ,  James William LUTHER ,  Bertold ENGLER ,  Andrea BESANA ,  Thomas Alan PEACH

Inventor： Frank MODICA ,  Nicholas CHOPAS ,  James William LUTHER ,  Bertold ENGLER ,  Andrea BESANA ,  Thomas Alan PEACH

IPC: C12M1/42 ,  C12M1/32 ,  C12M3/00

Abstract: Electroporation systems and methods are provided that include a processing assembly including a housing, a lid rotationally connectable to the housing, an opening in a top surface of the housing, an electroporation chamber below the opening in the housing, wherein the electroporation chamber comprises (i) two or more electrodes coated with an electrically conductive, non-cytotoxic material, and (ii) a gasket forming the shape of the electroporation chamber and defining the volume of one or more wells within the electroporation chamber. The system may include a docking station, the docking station comprising, a housing, a port in the housing configured to receive the processing assembly, a lid connected to the housing, one or more contacts configured to connect the docking station to an electroporation system housing.

公开(公告)号：US20070117158A1

公开(公告)日：2007-05-24

申请号：US11434321

申请日：2006-05-12

Applicant: Frank Coumans ,  Jan Greve ,  Frank Modica ,  Leon Terstappen ,  Arian Tibbe ,  John Verrant

Inventor： Frank Coumans ,  Jan Greve ,  Frank Modica ,  Leon Terstappen ,  Arian Tibbe ,  John Verrant

IPC: G06T7/20 ,  G01N33/567 ,  C12M1/34

CPC classification number: C12M41/36 ,  G01N15/1475

Abstract: The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity of the instruments prevents wider use, for example, CD4 analysis in HIV monitoring in resource-poor countries. The novel device, methods and algorithms disclosed herein largely overcome these limitations. Briefly, all cells in a biological sample are fluorescently labeled, but only the target cells are also magnetically labeled. In addition, non-magnetically labeled cells are imaged for viability in a modified slide configuration. The labeled sample, in a chamber or cuvet, is placed between two wedge-shaped magnets to selectively move the magnetically labeled cells to the observation surface of the cuvet. An LED illuminates the cells and a CCD camera captures the images of the fluorescent light emitted by the target cells. Image analysis performed with a novel algorithm provides a count of the cells on the surface that can be related to the target cell concentration of the original sample. The compact cytometer system provides a rugged, affordable and easy-to-use technique, which can be used in remote locations.

Abstract translation: 通过流式细胞术对流体细胞的计数被广泛应用于许多学科，例如评估不同体液中的白细胞亚群或环境样品，食品和体液中的细菌污染。 对于许多应用，仪器的成本，尺寸和复杂性阻止了更广泛的使用，例如资源贫乏国家的艾滋病毒监测中的CD 4分析。 本文公开的新颖的装置，方法和算法在很大程度上克服了这些限制。 简言之，生物样品中的所有细胞都被荧光标记，但只有靶细胞也被磁性标记。 另外，非磁性标记的细胞在修改的载玻片配置中的存活力被成像。 将标记的样品置于室或铜管中，放置在两个楔形磁体之间，以选择性地将磁性标记的细胞移动到铜管的观察表面。 LED照亮细胞，CCD相机捕获由靶细胞发射的荧光的图像。 用新算法进行的图像分析提供了与原始样品的靶细胞浓度相关的表面上的细胞计数。 紧凑型细胞仪系统提供坚固，经济实惠且易于使用的技术，可用于偏远地区。

公开(公告)号：US20050075244A1

公开(公告)日：2005-04-07

申请号：US10990378

申请日：2004-11-17

Applicant: Leonid Galperin ,  Frank Modica ,  Thomas McBride

Inventor： Leonid Galperin ,  Frank Modica ,  Thomas McBride

IPC: B01J23/656 ,  B01J37/00 ,  B01J37/02 ,  B01J37/24 ,  C10G35/085 ,  C10G35/09 ,  B01J23/62

CPC classification number: C10G35/09 ,  B01J23/6567 ,  B01J35/0093 ,  B01J37/0009 ,  B01J37/0207 ,  B01J37/24 ,  C10G35/085

Abstract: A process for preparing a naphtha reforming catalyst has been developed. The process involves the use of a chelating ligand such as ethylenediaminetetraacetic acid (EDTA). The aqueous solution of the chelating ligand and a tin compound is used to impregnate a support, e.g., alumina extrudates. A platinum-group metal is also an essential component of the catalyst. Rhenium may also be a component. A reforming process using the catalyst has enhanced yield, activity, and stability for conversion of naphtha into valuable gasoline and aromatic products.

Abstract translation: 已经开发了制备石脑油重整催化剂的方法。 该方法包括使用螯合配体如乙二胺四乙酸（EDTA）。 螯合配体和锡化合物的水溶液用于浸渍载体，例如氧化铝挤出物。 铂族金属也是催化剂的重要组成部分。 铼也可以是组分。 使用该催化剂的重整方法具有提高的石脑油转化成贵重汽油和芳香族产物的产率，活性和稳定性。

公开(公告)号：US20070191222A1

公开(公告)日：2007-08-16

申请号：US11697471

申请日：2007-04-06

Applicant: Leonid Galperin ,  Frank Modica ,  Thomas McBride

Inventor： Leonid Galperin ,  Frank Modica ,  Thomas McBride

IPC: B01J23/00 ,  B01J23/44

CPC classification number: C10G35/09 ,  B01J23/6567 ,  B01J35/0093 ,  B01J37/0009 ,  B01J37/0207 ,  B01J37/24 ,  C10G35/085

Abstract: A process for preparing a naphtha reforming catalyst has been developed. The process involves the use of a chelating ligand such as ethylenediaminetetraacetic acid (EDTA). The aqueous solution of the chelating ligand and a tin compound is used to impregnate a support, e.g., alumina extrudates. A platinum-group metal is also an essential component of the catalyst. Rhenium may also be a component. A reforming process using the catalyst has enhanced yield, activity, and stability for conversion of naphtha into valuable gasoline and aromatic products.

Abstract translation: 已经开发了制备石脑油重整催化剂的方法。 该方法包括使用螯合配体如乙二胺四乙酸（EDTA）。 螯合配体和锡化合物的水溶液用于浸渍载体，例如氧化铝挤出物。 铂族金属也是催化剂的重要组成部分。 铼也可以是组分。 使用该催化剂的重整方法具有提高的石脑油转化成贵重汽油和芳香族产物的产率，活性和稳定性。

公开(公告)号：US20070153280A1

公开(公告)日：2007-07-05

申请号：US11701765

申请日：2007-02-02

Applicant: Frank Coumans ,  Arthur Marlin ,  Frank Modica ,  John Verrant

Inventor： Frank Coumans ,  Arthur Marlin ,  Frank Modica ,  John Verrant

IPC: G01N21/25

CPC classification number: G01N21/6458 ,  G01N15/1475 ,  G01N2015/1006 ,  G01N2015/1488 ,  G01N2021/6421

Abstract: The present invention provides a system for imaging circulating tumor cells from blood after enrichment. The system is designed to provide optimum use in a clinical laboratory setting with minimum laboratory bench top space. Operator intervention is minimized compared to other analytical methodologies. The system is useful in the enumeration and identification of target cells in a sample specimen for screening and detection of early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies for individual patients.

Abstract translation: 本发明提供了一种用于在浓缩后从血液中循环肿瘤细胞成像的系统。 该系统设计为在临床实验室设置中提供最佳使用，具有最少的实验室台面空间。 与其他分析方法相比，操作员干预最小化。 该系统在用于筛选和检测早期转移前癌症的样品标本中的靶细胞的计数和鉴定中是有用的，响应于治疗监测疾病缓解和选择更有效的剂量方案或针对个体患者的替代疗法。

公开(公告)号：US20050215838A1

公开(公告)日：2005-09-29

申请号：US10807626

申请日：2004-03-24

Applicant: Antoine Negiz ,  Edwin Boldingh ,  Frank Modica ,  Gregory Maher

Inventor： Antoine Negiz ,  Edwin Boldingh ,  Frank Modica ,  Gregory Maher

IPC: C07C4/24 ,  C07C5/22 ,  C07C6/12

CPC classification number: C07C6/126 ,  C07C2529/26 ,  C07C15/08

Abstract: A catalyst, and a process for using the catalyst, that effectively converts and transalkylates indane and C10 and heavier polycyclic aromatics into C8 aromatics is herein disclosed. The catalyst comprises a solid-acid support such as mordenite plus a metal component such as rhenium. The catalyst provides excellent conversion of such heavy aromatic species as naphthalene, which is also observed by a decrease in the ending-boiling-point of a hydrocarbon stream passed over the catalyst. The same catalyst is also effective for transalkylation of lighter aromatics, thus yielding a valuable xylenes product stream out of the process.

Abstract translation: 本文公开了一种催化剂和使用该催化剂的方法，其有效地将茚满和C 10 N和更重的多环芳烃转化和烷基化到C 8芳烷烃中。 催化剂包括固体酸载体如丝光沸石和金属组分如铼。 该催化剂提供了诸如萘之类的重芳族物质的极好的转化率，这也是通过在催化剂上通过的烃流的终沸点降低而观察到的。 相同的催化剂对于较轻的芳族化合物的烷基转移也是有效的，因此在工艺中产生有价值的二甲苯产物流。

公开(公告)号：US4369130A

公开(公告)日：1983-01-18

申请号：US220275

申请日：1980-12-29

Applicant: Ralph J. Bertolacini ,  Eugene H. Hirschberg ,  Frank Modica

Inventor： Ralph J. Bertolacini ,  Eugene H. Hirschberg ,  Frank Modica

IPC: B01D53/50 ,  B01J23/10 ,  B01J29/06 ,  B01J29/08 ,  C10G11/05

CPC classification number: B01D53/508 ,  B01J29/061 ,  B01J29/088 ,  C10G11/05 ,  B01J23/10

Abstract: Sulfur oxides are removed from a gas by an absorbent comprising at least one inorganic oxide selected from the group consisting of the oxides of aluminum, magnesium, zinc, titanium, and calcium in association with at least one free or combined rare earth metal selected from the group consisting of lanthanum, cerium, praseodymium, samarium, and dysprosium, wherein the ratio by weight of inorganic oxide or oxides to rare earth metal or metals is from about 0.1 to about 30,000. Absorbed sulfur oxides are recovered as a sulfur-containing gas comprising hydrogen sulfide by contacting the spent absorbent with a hydrocarbon in the presence of a hydrocarbon cracking catalyst at a temperature from about 375.degree. to about 900.degree. C. The absorbent can be circulated through a fluidized catalytic cracking process together with the hydrocarbon cracking catalyst to reduce sulfur oxide emissions from the regeneration zone.

Abstract translation: 与含有至少一种选自铝，镁，锌，钛和钙的氧化物的至少一种无机氧化物的吸收剂一起从气体中除去硫氧化物，该至少一种无机氧化物与至少一种游离或组合的稀土金属组合， 由镧，铈，镨，钐和镝组成的组，其中无机氧化物或氧化物与稀土金属或金属的重量比为约0.1至约30,000。 通过在烃裂化催化剂存在下，在大约375°至大约900℃的温度下，使用废吸收剂与烃接触，将吸收的硫氧化物作为包含硫化氢的含硫气体回收。吸收剂可循环通过 流化催化裂化过程与烃裂化催化剂一起减少再生区的硫氧化物排放。