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公开(公告)号：US20230134948A1
公开(公告)日：2023-05-04
申请号：US17915376
申请日：2021-04-01
摘要： A staining method includes staining a biological sample with a coumarin fluorescent dye to provide a fluorescent-stained sample, and bringing the fluorescent-stained sample into contact with osmium tetroxide, further embedding the sample in an epoxy resin, and subsequently slicing the sample to provide a section sample including the fluorescent-stained sample.
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公开(公告)号：US20210354988A1
公开(公告)日：2021-11-18
申请号：US17277525
申请日：2019-08-08
申请人： NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM , HAYASHIBARA CO., LTD.
IPC分类号： C01B32/159 , C01B32/172 , C01B32/174 , H01L51/00
摘要： To reduce cost for the method for separating semiconducting carbon nanotube from a mixture of metallic and semiconducting carbon nanotubes. The separation method includes preparing a dispersion by mixing a first substance, a second substance, SDS, SC, and a mixture of metallic and semiconducting carbon nanotubes with a solvent, wherein the dispersion into two layers, which are a first layer mainly containing the first substance and a second layer mainly containing the second substance, whereby the semiconducting carbon nanotube is transferred into the first layer, and the metallic carbon nanotube is transferred into the second layer, wherein the first substance is an α-glucan which is composed of glucose linked via α-glucosidic linkage and which has a weight average molecular weight Mw of 4,000 to 7,000 and has a ratio in amount of α-1, 6 linked glucose residues to the entire glucose residues of 40 to 70%.
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公开(公告)号：US20180346949A1
公开(公告)日：2018-12-06
申请号：US15780706
申请日：2016-12-02
发明人： Seiichiro KISHISHITA , Shoko KANASHIMA , Manabu MIYATA , Takuo YAMAMOTO , Katsuhiko HINO , Tomoyuki NISHIMOTO
IPC分类号： C12P19/04 , C12P19/14 , C12P19/18 , A23L29/269 , A23P30/10
CPC分类号： C12P19/04 , A23B5/06 , A23L5/00 , A23L7/109 , A23L29/00 , A23L29/20 , A23L29/269 , A23P30/10 , A61K9/20 , A61K47/36 , C08B37/00 , C08L3/00 , C12P19/14 , C12P19/18 , C12Y302/01094
摘要： An object of the present invention is to provide an α-glucan mixture in a preferable molecular weight range, which can be made into a transparent film with advantageous strength and water solubility when an edible film is made by using the α-glucan mixture without adding any plasticizer.The above object is solved by providing an α-glucan mixture, which is obtainable by a process comprising the steps of gelatinizing waxy starch and liquefying the resulting gelatinized waxy starch by allowing an amylase to act on it, having the following characteristics (1) and (2): (1) having the weight average molecular weight (Mw) in a range of 150 kDa to 3,000 kDa; and (2) having the value of dividing weight average molecular weight (Mw) with number average molecular weight (Mn), Mw/Mn, of 35.1 or lower.
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4.发明申请公开(公告)号：US20180179245A1
公开(公告)日：2018-06-28
申请号：US15905407
申请日：2018-02-26
发明人： Takashi SHIBUYA , Seisuke IZAWA
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
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公开(公告)号：US20170320900A1
公开(公告)日：2017-11-09
申请号：US15653131
申请日：2017-07-18
发明人： Takashi SHIBUYA , Seisuke IZAWA
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
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6.发明授权Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid 有权包含含水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法公开(公告)号：US09186368B2
公开(公告)日：2015-11-17
申请号：US14295546
申请日：2014-06-04
IPC分类号： C07H17/04 , A61K31/7048 , C12P19/18 , C12P19/60 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
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7.发明申请BRANCHED ALPHA-GLUCAN, ALPHA-GLUCOSYLTRANSFERASE WHICH FORMS THE GLUCAN, THEIR PREPARATION AND USES 有权分支的ALPHA-GLUCAN，ALPHA-GLUCOSYLTRANSFERASE，其形成葡萄糖，其制备和用途公开(公告)号：US20150267234A1
公开(公告)日：2015-09-24
申请号：US14734607
申请日：2015-06-09
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。
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8.发明申请THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, CONTAINING ADENOSINE N1-OXIDE AS AN EFFECTIVE INGREDIENT 有权含有腺苷酸氧化酶作为有效成分的炎症性疾病治疗剂公开(公告)号：US20140315849A1
公开(公告)日：2014-10-23
申请号：US14323091
申请日：2014-07-03
发明人： Keizo KOHNO , Emiko OHASHI , Hajime KUSANO , Shigeharu FUKUDA , Tatsuya ISHIHARA
IPC分类号： A61K31/708 , A61K31/7076
CPC分类号： A61K31/7076 , A61K8/602 , A61K31/7052 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/708 , A61K45/06 , A61K2800/10 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07H19/067 , C07H19/167
摘要： The present invention has an object to provide an effective and safe therapeutic agent for inflammatory diseases such as sepsis, hepatitis, and inflammatory bowel disease, and solves the above object by providing a therapeutic agent for inflammatory diseases containing adenosine N1-oxide or a derivative thereof as an effective ingredient.
摘要翻译： 本发明的目的是提供一种用于炎症性疾病如败血症，肝炎和炎症性肠病的有效且安全的治疗剂，并且通过提供含有腺苷N1氧化物或其衍生物的炎性疾病的治疗剂来解决上述目的 作为有效成分。
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公开(公告)号：US20220202685A1
公开(公告)日：2022-06-30
申请号：US17609042
申请日：2020-05-01
发明人： Kiyomi AIZAWA , Masaki MIYAKE , Hitoshi MITSUZUMI
IPC分类号： A61K8/67 , A61K8/37 , A61K8/73 , A61K8/34 , A61K8/86 , A61Q19/10 , A61Q19/02 , A61Q19/08 , A61Q19/00
摘要： The present invention addresses the problem of providing a gel-type skin external composition containing a L-ascorbic acid derivative, which has excellent shape retention, stability, and excellent feeling of use even when salts coexist in the composition. The above problem is solved by providing a gel-type skin external composition containing a L-ascorbic acid derivative, a nonionic synthetic water-soluble polymer, and a natural water-soluble polysaccharide.
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公开(公告)号：US20180243195A1
公开(公告)日：2018-08-30
申请号：US15756698
申请日：2016-09-01
CPC分类号： A61K8/602 , A61K8/36 , A61K8/365 , A61K8/368 , A61K8/49 , A61K8/498 , A61K8/60 , A61K9/08 , A61K9/16 , A61K9/20 , A61K31/19 , A61K31/198 , A61K31/353 , A61K31/702 , A61K31/7048 , A61Q19/00 , A61Q19/02
摘要： [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin.[Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).
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