公开(公告)号：US10071042B2

公开(公告)日：2018-09-11

申请号：US15304181

申请日：2015-04-13

申请人： Hayashibara Co., Ltd.

发明人： Keizo Kohno ,  Satomi Miyata ,  Toshiharu Hanaya ,  Shigeharu Fukuda

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K8/60 ,  A61Q19/02 ,  A61Q19/08 ,  A61K8/44 ,  A61K31/7076 ,  A61K31/706 ,  A61K31/7064

摘要： The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5′-phosphate, analogs thereof, and their salts.

公开(公告)号：US20130065293A1

公开(公告)日：2013-03-14

申请号：US13666220

申请日：2012-11-01

申请人： Hayashibara Co., Ltd.

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12N9/10 ,  C12N1/20

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

公开(公告)号：US09186368B2

公开(公告)日：2015-11-17

申请号：US14295546

申请日：2014-06-04

申请人： Hayashibara Co., Ltd.

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C07H17/04 ,  A61K31/7048 ,  C12P19/18 ,  C12P19/60 ,  A61K9/16

CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

公开(公告)号：US20150267234A1

公开(公告)日：2015-09-24

申请号：US14734607

申请日：2015-06-09

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12P19/04 ,  C12P19/18

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

公开(公告)号：US09872872B2

公开(公告)日：2018-01-23

申请号：US14879280

申请日：2015-10-09

申请人： Hayashibara Co., Ltd.

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C07H17/04 ,  A61K31/7048 ,  C12P19/18 ,  C12P19/60 ,  A61K9/16

CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

公开(公告)号：US09528134B2

公开(公告)日：2016-12-27

申请号：US14734607

申请日：2015-06-09

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keiji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12P19/04 ,  C12P19/18 ,  A21D2/18 ,  A23C9/13 ,  A23C9/154 ,  A23L1/09 ,  A23L1/19 ,  A23L1/20 ,  A23L1/305 ,  A23L2/39 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00 ,  C08B37/00 ,  C12N9/10 ,  C12R1/06 ,  C12R1/09

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。

公开(公告)号：US09090923B2

公开(公告)日：2015-07-28

申请号：US14160749

申请日：2014-01-22

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12P19/18 ,  A21D2/18 ,  A23C9/13 ,  A23C9/154 ,  A23L1/09 ,  A23L1/19 ,  A23L1/20 ,  A23L1/305 ,  A23L2/39 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00 ,  C08B37/00 ,  C12N9/10 ,  C12P19/04 ,  C12R1/06 ,  C12R1/09

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitolis 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）在部分甲基化的葡萄糖醇中的2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的总含量为60％以上 醋酸盐 （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

公开(公告)号：US09066968B2

公开(公告)日：2015-06-30

申请号：US14169518

申请日：2014-01-31

申请人： HAYASHIBARA CO. LTD

发明人： Hitomi Ohta ,  Toshiharu Hanaya ,  Shigeharu Fukuda ,  Yoshikatsu Miwa ,  Toshio Miyake

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/715 ,  A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/28

CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/287 ,  A61K2300/00

摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

摘要翻译： 本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

公开(公告)号：US20170049142A1

公开(公告)日：2017-02-23

申请号：US15342462

申请日：2016-11-03

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keiji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： A23L33/21 ,  A61K9/20 ,  A61K9/06 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61K31/718 ,  A61K8/73 ,  A23C9/13 ,  A23C9/154 ,  A23L2/39 ,  A23L9/20 ,  A23L11/00 ,  A23L29/30 ,  A23L33/10 ,  A61Q11/00

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。

公开(公告)号：US09301968B2

公开(公告)日：2016-04-05

申请号：US14323091

申请日：2014-07-03

申请人： Hayashibara Co., Ltd.

发明人： Keizo Kohno ,  Emiko Ohashi ,  Hajime Kusano ,  Shigeharu Fukuda ,  Tatsuya Ishihara

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/708 ,  A61K45/06 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7052 ,  A61K31/7076 ,  C07H19/167 ,  C07H19/067

CPC分类号： A61K31/7076 ,  A61K8/602 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/708 ,  A61K45/06 ,  A61K2800/10 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07H19/067 ,  C07H19/167

摘要： The present invention has an object to provide an effective and safe therapeutic agent for inflammatory diseases such as sepsis, hepatitis, and inflammatory bowel disease, and solves the above object by providing a therapeutic agent for inflammatory diseases containing adenosine N1-oxide or a derivative thereof as an effective ingredient.

摘要翻译： 本发明的目的是提供一种用于炎症性疾病如败血症，肝炎和炎症性肠病的有效且安全的治疗剂，并且通过提供含有腺苷N1氧化物或其衍生物的炎性疾病的治疗剂来解决上述目的 作为有效成分。