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公开(公告)号：US20070238697A1
公开(公告)日：2007-10-11
申请号：US11634526
申请日：2006-12-05
申请人： John Jackson , Helen Burt
发明人： John Jackson , Helen Burt
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
摘要翻译： 组合物，方法等包括岩藻多糖如岩藻依聚糖以治疗手术粘连，关节炎和牛皮癣。
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公开(公告)号：US20070003629A1
公开(公告)日：2007-01-04
申请号：US11435780
申请日：2006-05-18
申请人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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公开(公告)号：US09186410B2
公开(公告)日：2015-11-17
申请号：US13581463
申请日：2011-03-01
申请人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
发明人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K33/24 , C07C217/00 , C07D207/46 , A61K47/10 , A61K9/51 , A61K47/34 , C08G65/34 , C08G65/48 , C08G83/00 , C08G65/333 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译： 本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基 。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的 在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。 此外，还提供了制造dHPG的方法。
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公开(公告)号：US20070298123A1
公开(公告)日：2007-12-27
申请号：US11830080
申请日：2007-07-30
申请人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K31/337 , A61F2/04 , A61F2/06 , A61K31/426 , A61K31/565 , A61K33/24 , A61P27/02 , C07C233/64 , C07D305/14 , C07K2/00 , C07K14/00 , C07J1/00 , C07H5/04 , C07D475/08 , C07D277/22 , A61P9/10 , A61P19/02 , A61K31/702 , A61K31/519 , A61F2/20 , A61K31/165
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20060240113A1
公开(公告)日：2006-10-26
申请号：US11435742
申请日：2006-05-18
申请人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K31/525 , A61K31/4745 , A61K31/427 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20060189785A1
公开(公告)日：2006-08-24
申请号：US11296184
申请日：2005-12-06
申请人： John Jackson , Jason Zastre , Helen Burt
发明人： John Jackson , Jason Zastre , Helen Burt
IPC分类号： C08G63/08
CPC分类号： A61K9/0019 , A61K9/0024 , A61K9/1075 , A61K31/337 , A61K47/10 , A61K47/32 , A61K47/34
摘要： This invention provides compositions comprising a hydrophobic drug, a biocompatible micelle forming polymer, and a biocompatible low molecular weight, water-soluble polymer. Also provided are devices for injection of such compositions and for the use of such compositions to form hydrophobic drug containing micelles within the body of a patient.
摘要翻译： 本发明提供了包含疏水性药物，生物相容性胶束形成聚合物和生物相容性低分子量水溶性聚合物的组合物。 还提供了用于注射这种组合物的装置，并且使用这种组合物在患者体内形成含有胶束的疏水性药物。
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公开(公告)号：US20060121117A1
公开(公告)日：2006-06-08
申请号：US11332170
申请日：2006-01-17
申请人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K9/14 , A61K31/525 , A61K31/4745 , A61K31/427 , A61K31/337
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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公开(公告)号：US20080020063A1
公开(公告)日：2008-01-24
申请号：US11830186
申请日：2007-07-30
申请人： William HUNTER , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William HUNTER , Lindsay Machan , A. Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K31/337 , A61F2/04 , A61F2/06 , A61K31/4985 , A61K31/728 , A61P9/00 , A61K33/24 , A61K31/56 , A61K31/426 , A61K31/165
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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公开(公告)号：US20070003630A1
公开(公告)日：2007-01-04
申请号：US11435854
申请日：2006-05-18
申请人： William Hunter , Lindsay Machan , A. Larry-Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Larry-Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
摘要翻译： 本发明提供了包含抗血管生成因子和聚合物载体的组合物。 抗血管生成因子的代表性实例包括抗侵袭因子，视黄酸及其衍生物和紫杉醇。 还提供了栓塞血管，消除胆汁，尿道，食管和气管/支气管阻塞物的方法。
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公开(公告)号：US20050123605A1
公开(公告)日：2005-06-09
申请号：US10959349
申请日：2004-10-07
申请人： William Hunter , Lindsay Machan , A. Larry-Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
发明人： William Hunter , Lindsay Machan , A. Larry-Arsenault , Helen Burt , John Jackson , Stephen Dordunoo
IPC分类号： C07D305/14 , A61F2/02 , A61F2/06 , A61F2/84 , A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/70 , A61K31/122 , A61K31/136 , A61K31/175 , A61K31/185 , A61K31/19 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/519 , A61K31/57 , A61K33/24 , A61K38/00 , A61K38/55 , A61K38/57 , A61K45/00 , A61K45/06 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61K47/48 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61P1/04 , A61P1/16 , A61P7/04 , A61P9/00 , A61P11/00 , A61P13/02 , A61P27/02 , A61P35/00 , C07K14/81 , C08L23/08 , C08L29/04 , C08L67/04 , A61K9/20 , A61K31/20
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K9/7007 , A61K31/122 , A61K31/136 , A61K31/165 , A61K31/185 , A61K31/203 , A61K31/335 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/4745 , A61K31/519 , A61K31/525 , A61K31/555 , A61K31/565 , A61K31/57 , A61K31/702 , A61K33/00 , A61K33/06 , A61K33/24 , A61K33/30 , A61K38/57 , A61K45/06 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/622 , A61L2430/36 , B82Y5/00 , C07C233/64 , C07K14/811 , C08L23/0853 , C08L29/04 , C08L67/04 , C08L2203/02 , C08L2312/00 , Y10S977/773 , Y10S977/915 , C08L23/08 , A61K2300/00 , C08L2666/18 , C08L2666/06 , C08L2666/04
摘要： The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
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