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公开(公告)号：US20110318309A1
公开(公告)日：2011-12-29
申请号：US13203144
申请日：2010-02-25
申请人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
IPC分类号： A61K35/74 , C12P17/06 , C07H21/04 , A61P15/00 , A61P3/06 , A61P19/10 , A61P9/10 , C12N1/20 , A61P35/00
CPC分类号： C12R1/01 , A23L33/105 , A61K31/7048 , A61K35/74 , C12P17/06
摘要： The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
摘要翻译： 本发明涉及在50％以上的24小时内将大豆黄素转化为雌马酚的能力的微生物; 含有微生物的食品/饮料或药物组合物; 使用微生物的雌马酚生产方法; 以及能够特异性检测微生物的核酸片段。
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公开(公告)号：US20090253643A1
公开(公告)日：2009-10-08
申请号：US12092355
申请日：2006-11-02
申请人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
IPC分类号： A61K31/7032 , C07C31/18 , C07H3/02 , C07H15/00 , C07H3/06 , C07H3/04 , C07C35/16 , A61K31/047 , A61K31/7004 , A61K31/702 , A61K31/7016 , A61P5/00 , C12N1/00 , C12Q1/04
CPC分类号： C12Q1/04 , A23L5/00 , A23L21/00 , A23L27/33 , A23L29/30 , A23L29/37 , A23L33/125 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/702
摘要： An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equal in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equal and a method of detecting the same. Provided are an equal concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equal concentration-raising or reducing agent; a method of raising or reducing the concentration of equal by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equal; and a method of detecting a microorganism having conversion ability to equal by use of the selective medium.
摘要翻译： 发明内容本发明的目的在于提供一种具有调节体内相同浓度并且能够长期耐受高安全性的药物，食品和饮料，并为具有转化能力的微生物提供选择性培养基 以及相同的检测方法。 提供含有碳水化合物作为活性成分的等浓度升高或还原剂; 使用碳水化合物制备等浓度升高或还原剂; 通过以有效剂量施用碳水化合物来提高或降低相等浓度的方法; 含有转化能力相等的微生物碳水化合物的选择培养基; 以及通过使用选择培养基检测具有相等转化能力的微生物的方法。
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3.发明授权公开(公告)号：US08992947B2
公开(公告)日：2015-03-31
申请号：US13264811
申请日：2010-04-22
申请人： Hideyuki Akaza , Seiji Naito , Toshinori Oka
发明人： Hideyuki Akaza , Seiji Naito , Toshinori Oka
IPC分类号： A61P35/00 , A61K31/513 , G01N33/68 , C12Q1/68 , G01N33/574
CPC分类号： A61K31/513 , A61K2300/00 , C12N2320/31 , G01N33/57438 , G01N2333/91017 , G01N2800/52
摘要： The present invention developed a novel antitumor agent for renal cell carcinoma that cannot be fully treated by the existing therapies. The present invention provides an antitumor agent comprising a combination drug of tegafur/gimeracil/oteracil potassium that ensures an excellent therapeutic effect in renal cell carcinoma patients that is superior to that of the existing therapies, by way of selecting the patients based on thymidylate synthase.
摘要翻译： 本发明开发了一种新的抗肿瘤剂，不能用现有疗法完全治疗肾细胞癌。 本发明提供了一种抗癌剂，其包含替加氟/吉美嘧啶/奥替卡尔钾的组合药物，其通过选择基于胸苷酸合酶的患者，确保优于现有疗法的肾细胞癌患者的优异治疗效果。
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4.发明申请公开(公告)号：US20120101102A1
公开(公告)日：2012-04-26
申请号：US13264811
申请日：2010-04-22
申请人： Hideyuki Akaza , Seiji Naito , Toshinori Oka
发明人： Hideyuki Akaza , Seiji Naito , Toshinori Oka
CPC分类号： A61K31/513 , A61K2300/00 , C12N2320/31 , G01N33/57438 , G01N2333/91017 , G01N2800/52
摘要： The present invention developed a novel antitumor agent for renal cell carcinoma that cannot be fully treated by the existing therapies. The present invention provides an antitumor agent comprising a combination drug of tegafur/gimeracil/oteracil potassium that ensures an excellent therapeutic effect in renal cell carcinoma patients that is superior to that of the existing therapies, by way of selecting the patients based on thymidylate synthase.
摘要翻译： 本发明开发了一种新的抗肿瘤剂，不能用现有疗法完全治疗肾细胞癌。 本发明提供了一种抗癌剂，其包含替加氟/吉美嘧啶/奥替卡尔钾的组合药物，其通过选择基于胸苷酸合酶的患者，确保优于现有疗法的肾细胞癌患者的优异治疗效果。
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公开(公告)号：US09080197B2
公开(公告)日：2015-07-14
申请号：US12092355
申请日：2006-11-02
申请人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Hideyuki Akaza
IPC分类号： A61K31/7004 , A61K31/702 , A61K31/047 , A61P5/00 , C12Q1/04 , A23L1/09 , A23L1/236 , A61K31/7016
CPC分类号： C12Q1/04 , A23L5/00 , A23L21/00 , A23L27/33 , A23L29/30 , A23L29/37 , A23L33/125 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/702
摘要： An object of the invention is to provide a medical drug, a food and drink having a role in regulating the concentration of equol in vivo and being capable of taking for a long time with high safety and provide a selective medium for a microorganism having conversion ability to equol and a method of detecting the same. Provided are an equol concentration-raising or reducing agent containing a carbohydrate as an active ingredient; use of a carbohydrate for producing the equol concentration-raising or reducing agent; a method of raising or reducing the concentration of equol by administrating a carbohydrate in an effective dose; a selective medium containing a carbohydrate for a microorganism having conversion ability to equol; and a method of detecting a microorganism having conversion ability to equol by use of the selective medium.
摘要翻译： 本发明的目的在于提供一种能够在体内调节雌马酚的浓度，能够长时间高安全性地使用的药物，食品和饮料，具有转化能力的微生物的选择性培养基 至雌马酚及其检测方法。 提供含有碳水化合物作为活性成分的雌马酚浓度升高或还原剂; 使用碳水化合物制备雌马酚浓度升高或还原剂; 通过以有效剂量施用碳水化合物来提高或降低雌马酚的浓度的方法; 一种选择性培养基，其含有具有对牛尿酚转化能力的微生物的碳水化合物; 以及通过使用选择性培养基检测具有牛尿酚转化能力的微生物的方法。
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公开(公告)号：US08420073B2
公开(公告)日：2013-04-16
申请号：US13203144
申请日：2010-02-25
申请人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
发明人： Hirokazu Tsuji , Koji Nomoto , Kaoru Moriyama , Hideyuki Akaza
CPC分类号： C12R1/01 , A23L33/105 , A61K31/7048 , A61K35/74 , C12P17/06
摘要： The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
摘要翻译： 本发明涉及在50％以上的24小时内将大豆黄素转化为雌马酚的能力的微生物; 含有微生物的食品/饮料或药物组合物; 使用微生物的雌马酚生产方法; 以及能够特异性检测微生物的核酸片段。
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公开(公告)号：US20100166840A1
公开(公告)日：2010-07-01
申请号：US12300622
申请日：2007-05-11
申请人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
发明人： Homhuan Atthachai , Kentaro Kogure , Hideyoshi Harashima , Ikuya Yano , Yoshio Hatakeyama , Hidehiro Yokomizo , Hideyuki Akaza
CPC分类号： A61K9/127 , A61K9/1271 , A61K35/74 , A61K39/04 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , A61K2039/57
摘要： The object is to provide a liposome by which a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW) can be pharmaceutically prepared in a form applicable to a living body (i.e., a form in which the bacterial cell component can be dispersed in an aqueous solvent and has a controlled size) without using any surfactant. Disclosed is a liposome having a lipid membrane containing a bacterial cell component insoluble in water and an organic solvent (e.g., BCG-CW).
摘要翻译： 本发明的目的是提供一种可溶于水和有机溶剂（例如BCG-CW）的细菌细胞组分可以以适用于生物体的形式（即细菌细胞成分 可以分散在水性溶剂中并具有受控的尺寸），而不使用任何表面活性剂。 公开了具有含有不溶于水的细菌细胞成分和有机溶剂（例如BCG-CW）的脂质膜的脂质体。
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