公开(公告)号：US20050250795A1

公开(公告)日：2005-11-10

申请号：US11131646

申请日：2005-05-18

Applicant: M. Leanna ,  Steven Hannick ,  Michael Rasmussen ,  Jien-Heh Tien ,  Lakshmi Bhagavatula ,  Pulla Singam ,  Bradley Gates ,  Lawrence Kolaczkowski ,  Ramesh Patel ,  Greg Wayne ,  Greg Lannoye ,  Weijiang Zhang ,  Zhenping Tian ,  Kirill Lukin ,  Bikshandarkoil Narayanan ,  David Riley ,  Howard Morton ,  Sou-Jen Chang ,  Cynthia Curty ,  Daniel Plata ,  John Bellettini ,  Bhadra Shelat ,  Tiffany Spitz ,  Cheng-Xi Yang

Inventor： M. Leanna ,  Steven Hannick ,  Michael Rasmussen ,  Jien-Heh Tien ,  Lakshmi Bhagavatula ,  Pulla Singam ,  Bradley Gates ,  Lawrence Kolaczkowski ,  Ramesh Patel ,  Greg Wayne ,  Greg Lannoye ,  Weijiang Zhang ,  Zhenping Tian ,  Kirill Lukin ,  Bikshandarkoil Narayanan ,  David Riley ,  Howard Morton ,  Sou-Jen Chang ,  Cynthia Curty ,  Daniel Plata ,  John Bellettini ,  Bhadra Shelat ,  Tiffany Spitz ,  Cheng-Xi Yang

IPC: C07D473/18 ,  A61K31/522 ,  C07B53/00 ,  C07B61/00 ,  C07C303/30 ,  C07C309/45 ,  C07C309/73 ,  C07D473/00 ,  C07D473/12 ,  C07D473/32 ,  C07D473/40

CPC classification number: C07D473/00 ,  C07C309/73 ,  C07D473/18 ,  Y02P20/55

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

Abstract translation: 用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，另一个是R _{1和R 2是-C（O）C 3 -C 21饱和或单不饱和的任选取代的烷基和 R 3是OH或H; 或其药学上可接受的盐。}

公开(公告)号：US06184376B2

公开(公告)日：2001-02-06

申请号：US09130214

申请日：1998-08-06

Applicant: M. Robert Leanna ,  Steven M. Hannick ,  Michael Rasmussen ,  Jien-Heh J. Tien ,  Lakshmi Bhagavatula ,  Pulla Reddy Singam ,  Bradley D. Gates ,  Lawrence Kolaczkowski ,  Ramesh R. Patel ,  Greg Wayne ,  Greg Lannoye ,  Weijiang Zhang ,  Zhenping Tian ,  Kirill A. Lukin ,  Bikshandarkoil A. Narayanan ,  David A. Riley ,  Howard Morton ,  Sou-Jen Chang ,  Cynthia B. Curty ,  Daniel Plata ,  John Bellettini ,  Bhadra Shelat ,  Tiffany Spitz ,  Cheng-Xi Yang

Inventor： M. Robert Leanna ,  Steven M. Hannick ,  Michael Rasmussen ,  Jien-Heh J. Tien ,  Lakshmi Bhagavatula ,  Pulla Reddy Singam ,  Bradley D. Gates ,  Lawrence Kolaczkowski ,  Ramesh R. Patel ,  Greg Wayne ,  Greg Lannoye ,  Weijiang Zhang ,  Zhenping Tian ,  Kirill A. Lukin ,  Bikshandarkoil A. Narayanan ,  David A. Riley ,  Howard Morton ,  Sou-Jen Chang ,  Cynthia B. Curty ,  Daniel Plata ,  John Bellettini ,  Bhadra Shelat ,  Tiffany Spitz ,  Cheng-Xi Yang

IPC: C07D47318

CPC classification number: C07D473/00 ,  C07C309/73 ,  C07D473/18 ,  Y02P20/55

Abstract: Methods and novel intermediates of the formula: wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2CH2—, R8 is C1-C21 alkyl or a C2-C21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, C1-C6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

Abstract translation: 下式的方法和新型中间体：其中R6和R7是低级烷基或苄基或R6和R7一起是-CH 2 CH 2 - ， - CH 2 CH 2 CH 2 - 或-CH 2 CH 2 CH 2 CH 2 CH 2 - ，R 8是C 1 -C 21烷基或C 2 -C 21单不饱和链烯基， 其可以任选地被独立地选自羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷氧基C 1 -C 6烷基，C 1 -C 6烷酰基，氨基，卤素，氰基，叠氮基，氧代 ，巯基和硝基，R9是醇保护基。 中间体可用于制备下式的无环核苷衍生物：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或单不饱和的，任选取代的 烷基和R 3是OH或H; 或其药学上可接受的盐。

公开(公告)号：US1069693A

公开(公告)日：1913-08-12

申请号：US1911640671

申请日：1911-07-26

Applicant: HAY HOWARD MORTON

Inventor： HAY HOWARD MORTON

CPC classification number: F16F15/02

公开(公告)号：US06878844B2

公开(公告)日：2005-04-12

申请号：US10315580

申请日：2002-12-09

Applicant: M. Robert Leanna ,  Michael Rasmussen ,  Howard Morton ,  Zhenping Tian ,  Daniel Plata ,  Bradley D. Gates ,  Bikshandarkoil A. Narayanan

Inventor： M. Robert Leanna ,  Michael Rasmussen ,  Howard Morton ,  Zhenping Tian ,  Daniel Plata ,  Bradley D. Gates ,  Bikshandarkoil A. Narayanan

IPC: C07D473/18 ,  A61K31/522 ,  C07B53/00 ,  C07B61/00 ,  C07C303/30 ,  C07C309/45 ,  C07C309/73 ,  C07D473/00 ,  C07D473/12 ,  C07D473/32 ,  C07D473/40 ,  C07C69/00

CPC classification number: C07D473/00 ,  C07C309/73 ,  C07D473/18 ,  Y02P20/55

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

Abstract translation: 用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或单不饱和，任选取代的 烷基和R 3是OH或H; 或其药学上可接受的盐。

公开(公告)号：US06613936B1

公开(公告)日：2003-09-02

申请号：US09692599

申请日：2000-10-18

Applicant: M. Robert Leanna ,  Steven M. Hannick ,  Michael Rasmussen ,  Howard Morton ,  Daniel Plata

Inventor： M. Robert Leanna ,  Steven M. Hannick ,  Michael Rasmussen ,  Howard Morton ,  Daniel Plata

IPC: C07C6900

CPC classification number: C07D473/00 ,  C07C309/73 ,  C07D473/18 ,  Y02P20/55

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

Abstract translation: 用于制备下式的无环核苷衍生物的方法和新型中间体：其中R 1和R 2中的一个是氨基酸酰基，R 1和R 2中的另一个是-C（O）C 3 -C 21饱和或单不饱和，任选取代的 烷基和R 3是OH或H; 或其药学上可接受的盐。

公开(公告)号：US728461A

公开(公告)日：1903-05-19

申请号：US1901081943

申请日：1901-11-11

Applicant: HAY HOWARD MORTON

Inventor： HAY HOWARD MORTON

CPC classification number: B32B21/14 ,  D21H19/34 ,  Y10T428/31982