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    Miniaturized fluid delivery and analysis system
    4.
    发明授权
    Miniaturized fluid delivery and analysis system 有权
    小型化流体输送和分析系统

    公开(公告)号：US07186383B2

    公开(公告)日：2007-03-06

    申请号：US11078993

    申请日：2005-03-11

    Applicant: James Russell Webster ,  Yuan-Fong Kuo ,  Shaw-Tsu Wang ,  Lung-Wen Tai

    Inventor： James Russell Webster ,  Yuan-Fong Kuo ,  Shaw-Tsu Wang ,  Lung-Wen Tai

    IPC: G01N1/10

    CPC classification number: F04B43/043 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0605 ,  B01L2400/0638 ,  F04B43/02 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T436/2575

    Abstract: An apparatus providing a fluidic cartridge including a first and second substrate and an intermediate interlayer is disclosed. The intermediate interlayer is sealedly interfaced between the first and second substrates to form therein a plurality of channels of capillary dimensions. The apparatus further includes an open reservoir, a pump chamber and a reaction chamber. The open reservoir and reaction chamber are each connected to the pump chamber through the channels. The open reservoir and reaction chamber are in fluid communication with each other via the channels. The apparatus further provides a fluid flow controlling structure, formed in the fluidic cartridge, which restricts a flow of a fluid through the reaction chamber to one direction. The apparatus further provides a linear actuator for providing a pumping action in the pump chamber to pump the fluid to recirculate from the reaction chamber to the open reservior via the channels and pump chamber.

    Abstract translation: 公开了一种提供包括第一和第二基板和中间夹层的流体盒的装置。 中间层间密封地接合在第一和第二基板之间以在其中形成多个毛细管尺寸的通道。 该装置还包括开放储存器，泵室和反应室。 开放的储存器和反应室各自通过通道连接到泵室。 开放的储存器和反应室通过通道彼此流体连通。 该装置还提供了一种流体流动控制结构，其形成在流体盒中，其将流体通过反应室限制流向一个方向。 该装置还提供一种线性致动器，用于在泵室中提供泵送作用以泵送流体，以经由通道和泵室从反应室再循环到开放储存器。

    BULK ACOUSTIC WAVE RESONATOR WITH INCREASED DYNAMIC RANGE
    5.
    发明公开
    BULK ACOUSTIC WAVE RESONATOR WITH INCREASED DYNAMIC RANGE 审中-公开

    公开(公告)号：US20240183822A1

    公开(公告)日：2024-06-06

    申请号：US18402113

    申请日：2024-01-02

    Applicant: James Russell Webster ,  Ian Robert Harmon

    Inventor： James Russell Webster ,  Ian Robert Harmon

    IPC: G01N29/036 ,  G01N27/327 ,  G01N29/02 ,  G01N33/53

    CPC classification number: G01N29/036 ,  G01N27/327 ,  G01N29/022 ,  G01N33/5306 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

    Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.

    Method for defining regions of differing porosity of a nitrocellulose film on a substrate
    7.
    发明申请
    Method for defining regions of differing porosity of a nitrocellulose film on a substrate 审中-公开
    用于限定基材上的硝酸纤维素膜的不同孔隙率的区域的方法

    公开(公告)号：US20090280304A1

    公开(公告)日：2009-11-12

    申请号：US12437520

    申请日：2009-05-07

    Applicant: Ko-Yuan Tseng ,  Shaw-Tzu Wang ,  James Russell Webster

    Inventor： Ko-Yuan Tseng ,  Shaw-Tzu Wang ,  James Russell Webster

    IPC: B32B5/18 ,  B44C1/22 ,  C23F1/08

    CPC classification number: B01D67/0088 ,  B01D2323/283 ,  Y10T428/24802

    Abstract: A method of forming a pattern on a nitrocellulose film on a substrate by providing a nitrocellulose based film of uniform porosity on a substrate; defining a desired pattern on said substrate wherein at least one region of lower porosity is defined and wherein at least one region of normal porosity is defined; exposing to a flow of a suitable solvent vapor over said region of lower porosity wherein said nitrocellulose based film of said region of lower porosity is dissolved by said suitable solvent vapor; removing said suitable solvent vapor and said nitrocellulose based film from said region of lower porosity wherein said lower porosity is capable of separating multiple experiments that are performed simultaneously over said region of normal porosity.

    Abstract translation: 通过在基材上提供均匀孔隙率的硝酸纤维素基膜，在基材上的硝酸纤维素膜上形成图案的方法; 在所述衬底上限定期望的图案，其中限定了低孔隙率的至少一个区域，并且其中定义了至少一个正常孔隙率的区域; 暴露于较低孔隙率的所述区域上的合适溶剂蒸气流，其中所述较低孔隙率的所述硝酸纤维素基膜通过所述合适的溶剂蒸气溶解; 从所述较低孔隙率的区域除去所述合适的溶剂蒸气和所述硝化纤维素基膜，其中所述较低孔隙率能够分离在所述正常孔隙率区域上同时进行的多个实验。

    Capillary electrophoresis devices
    9.
    发明授权
    Capillary electrophoresis devices 失效
    毛细管电泳装置

    公开(公告)号：US07211184B2

    公开(公告)日：2007-05-01

    申请号：US10911455

    申请日：2004-08-04

    Applicant: James Russell Webster ,  Yuan-Fong Kuo ,  Shao-Tsu Wang ,  Chun-Hsien Lee

    Inventor： James Russell Webster ,  Yuan-Fong Kuo ,  Shao-Tsu Wang ,  Chun-Hsien Lee

    IPC: G01N27/453

    CPC classification number: G01N27/44756 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0829 ,  B01L2400/0421

    Abstract: A capillary electrophoresis device as well as a process for fabrication of the device is disclosed. The capillary electrophoresis device comprises a device body structure having a plurality of reservoirs arrayed thereon for loading a sample, and a plurality of rows of grooves transversely defined to be connected with the reservoirs for receiving at least a capillary electrophoresis chip. The capillary electrophoresis chip comprises a straight main separation channel, an injection channel, and a plurality of sample transport channels defined thereon in liquid communication with the reservoirs. After an electrode means is applied, the sample can be transported into the separation channel for detection and analysis.

    Abstract translation: 公开了一种毛细管电泳装置以及该装置的制造方法。 毛细管电泳装置包括具有排列在其上的用于装载样品的多个储存器的装置主体结构，以及横向限定为与储存器连接以用于至少接收毛细管电泳芯片的多排凹槽。 毛细管电泳芯片包括直接主分离通道，注射通道和限定在其上的与储存器液体连通的多个样品输送通道。 在施加电极装置之后，可以将样品运送到分离通道中进行检测和分析。

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