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    BULK ACOUSTIC WAVE RESONATOR WITH INCREASED DYNAMIC RANGE
    1.
    发明公开
    BULK ACOUSTIC WAVE RESONATOR WITH INCREASED DYNAMIC RANGE 审中-公开

    公开(公告)号：US20240183822A1

    公开(公告)日：2024-06-06

    申请号：US18402113

    申请日：2024-01-02

    Applicant: James Russell Webster ,  Ian Robert Harmon

    Inventor： James Russell Webster ,  Ian Robert Harmon

    IPC: G01N29/036 ,  G01N27/327 ,  G01N29/02 ,  G01N33/53

    CPC classification number: G01N29/036 ,  G01N27/327 ,  G01N29/022 ,  G01N33/5306 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

    Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.

    Miniaturized fluid delivery and analysis system
    5.
    发明授权
    Miniaturized fluid delivery and analysis system 有权
    小型化流体输送和分析系统

    公开(公告)号：US07186383B2

    公开(公告)日：2007-03-06

    申请号：US11078993

    申请日：2005-03-11

    Applicant: James Russell Webster ,  Yuan-Fong Kuo ,  Shaw-Tsu Wang ,  Lung-Wen Tai

    Inventor： James Russell Webster ,  Yuan-Fong Kuo ,  Shaw-Tsu Wang ,  Lung-Wen Tai

    IPC: G01N1/10

    CPC classification number: F04B43/043 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0605 ,  B01L2400/0638 ,  F04B43/02 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T436/2575

    Abstract: An apparatus providing a fluidic cartridge including a first and second substrate and an intermediate interlayer is disclosed. The intermediate interlayer is sealedly interfaced between the first and second substrates to form therein a plurality of channels of capillary dimensions. The apparatus further includes an open reservoir, a pump chamber and a reaction chamber. The open reservoir and reaction chamber are each connected to the pump chamber through the channels. The open reservoir and reaction chamber are in fluid communication with each other via the channels. The apparatus further provides a fluid flow controlling structure, formed in the fluidic cartridge, which restricts a flow of a fluid through the reaction chamber to one direction. The apparatus further provides a linear actuator for providing a pumping action in the pump chamber to pump the fluid to recirculate from the reaction chamber to the open reservior via the channels and pump chamber.

    Abstract translation: 公开了一种提供包括第一和第二基板和中间夹层的流体盒的装置。 中间层间密封地接合在第一和第二基板之间以在其中形成多个毛细管尺寸的通道。 该装置还包括开放储存器，泵室和反应室。 开放的储存器和反应室各自通过通道连接到泵室。 开放的储存器和反应室通过通道彼此流体连通。 该装置还提供了一种流体流动控制结构，其形成在流体盒中，其将流体通过反应室限制流向一个方向。 该装置还提供一种线性致动器，用于在泵室中提供泵送作用以泵送流体，以经由通道和泵室从反应室再循环到开放储存器。

    Micro valve actuator
    9.
    发明授权
    Micro valve actuator 失效
    微型阀门执行器

    公开(公告)号：US06527003B1

    公开(公告)日：2003-03-04

    申请号：US09717016

    申请日：2000-11-22

    Applicant: James Russell Webster

    Inventor： James Russell Webster

    IPC: F16K3102

    CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K31/02 ,  F16K99/0015 ,  F16K99/0036 ,  F16K2099/008 ,  G01N2035/00247 ,  Y10T137/0491

    Abstract: A simple micro valve actuator is disclosed. The micro valve actuator of this invention comprises a sealed vacuum chamber. The micro valve is actuated by providing a current to a thin film heater, which in turn weakens and, under the atmospheric pressure differential, breaks a diaphragm sealing said vacuum chamber whereby the vacuum inside the chamber is released. By applying the micro valve actuator of this invention to a microfluidic channel with a micro valve, the resulting pressure differential deforms the section of the microchannel at the micro valve area and adjacent to the vacuum chamber so to change the flow inside the microchannel. In the preferred embodiments of this invention, the chamber may be prepared in a silicon, glass, or plastic substrate and a diaphragm is vacuum bonded to seal the chamber. The diaphragm may comprise a metallic gas-impermeable film. A releasing member comprising a thin-film metallic heater is then microfabricated on the diaphragm. The assembly so prepared may be bonded to a glass or plastic substrate that contains a microchannel in which a micro valve is prepared. The invented micro valve actuator is suited for a microfluidic platform in changing the flow in a microchannel.

    Abstract translation: 公开了一种简单的微阀致动器。 本发明的微型阀致动器包括一个密封的真空室。 通过向薄膜加热器提供电流来致动微型阀，薄膜加热器又被弱化，并且在大气压差下破坏了密封所述真空室的隔膜，由此腔室内的真空被释放。 通过将本发明的微阀致动器应用于具有微阀的微流体通道，所产生的压力差使微通道的微通道区域与真空室相邻地变形，从而改变微通道内的流动。 在本发明的优选实施例中，室可以制备在硅，玻璃或塑料基板中，并且隔膜被真空接合以密封室。 隔膜可以包括金属气体不可渗透膜。 然后将包含薄膜金属加热器的释放构件在隔膜上微制成。 如此制备的组件可以结合到包含其中制备微型阀的微通道的玻璃或塑料基板。 本发明的微阀致动器适用于微流体平台，以改变微通道中的流动。

    Microfluidic actuator
    10.
    发明授权
    Microfluidic actuator 失效
    微流控制器

    公开(公告)号：US06521188B1

    公开(公告)日：2003-02-18

    申请号：US09717015

    申请日：2000-11-22

    Applicant: James Russell Webster

    Inventor： James Russell Webster

    IPC: B01L300

    CPC classification number: B01L3/50273 ,  B01L2300/0816 ,  B01L2400/049 ,  B01L2400/0677 ,  B01L2400/0683 ,  F04B19/006 ,  F04F3/00 ,  Y10T137/0396 ,  Y10T137/2224

    Abstract: A simple microfluidic actuator includes a sealed vacuum chamber actuated by providing a current to a thin film heater, which in turn weakens and, under the atmospheric pressure differential, breaks a diaphragm sealing said vacuum chamber whereby the vacuum inside said chamber is released. By applying the microfluidic actuator to a microfluidic network the resulting pressure differential can be used to generate a pumping force with the microfluidic network. The chamber may be prepared in a silicon, glass, or plastic substrate. The diaphragm may be a metallic gas-impermeable film. A releasing member comprising a thin-film metallic heater is then microfabricated on the diaphragm. The assembly so prepared may be bonded to a glass or plastic substrate that contains a network of microchannels. The microfluidic actuator is suited for a microfluidic platform in generating driving powers for operations including pumping, metering, mixing and valving of liquid samples.

    Abstract translation: 简单的微流体致动器包括通过向薄膜加热器提供电流而致动的密封真空室，薄膜加热器进一步削弱，并且在大气压力差下，破坏密封所述真空室的膜片，由此释放所述室内的真空。 通过将微流体致动器应用于微流体网络，所得到的压力差可用于产生具有微流控网络的泵送力。 室可以制备在硅，玻璃或塑料衬底中。 隔膜可以是金属气体不可渗透膜。 然后将包含薄膜金属加热器的释放构件在隔膜上微制成。 如此制备的组件可以结合到包含微通道网络的玻璃或塑料基板上。 微流体致动器适用于微流体平台，用于产生用于液体样品的泵送，计量，混合和阀门操作的驱动功率。

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