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    Spinal fluid introduction
    1.
    发明授权
    Spinal fluid introduction 失效
    脊柱液介绍

    公开(公告)号：US07662133B2

    公开(公告)日：2010-02-16

    申请号：US10782900

    申请日：2004-02-23

    申请人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke ,  Peter A. Weissman

    发明人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke ,  Peter A. Weissman

    IPC分类号： A61M37/00 ,  A61B5/103 ,  A61B5/117

    CPC分类号： A61M5/1456 ,  A61B17/3401 ,  A61B17/8822 ,  A61M5/16827 ,  A61M5/16854 ,  A61M2025/0007 ,  A61M2205/3331

    摘要： A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.

    摘要翻译： 流体引入系统包括导引器，其构造成在脊柱内产生至少69kPa的压力，以及操作器，其配置成致动导引器以根据预定流体导入曲线将流体引入脊柱。 该系统可以包括具有用于接收指示流体引入参数的流体引入数据的代码的计算机可读介质，以及用于在与流体引入数据的时间相关的时间接收表示患者的响应的响应数据。 用于引入流体的方法包括将第一导引器定位在脊柱的第一部分中，将第二导引器定位在脊柱的第二不同部分中，并且不移除第一和第二导引器，将流体引入脊柱的第一部分 与第一导引器一起引入流体到第二引导器到脊柱的第二部分。

    SPINAL FLUID INTRODUCTION
    2.
    发明申请
    SPINAL FLUID INTRODUCTION 审中-公开
    脊柱液介绍

    公开(公告)号：US20100094229A1

    公开(公告)日：2010-04-15

    申请号：US12632038

    申请日：2009-12-07

    申请人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke

    发明人： Nelson Scarborough ,  John V. Hamilton ,  Andy H. Uchida ,  Ralph I. McNall ,  Steven Lepke

    IPC分类号： A61M5/315

    CPC分类号： A61M5/1456 ,  A61B17/3401 ,  A61B17/8822 ,  A61M5/16827 ,  A61M5/16854 ,  A61M2025/0007 ,  A61M2205/3331

    摘要： A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.

    摘要翻译： 流体引入系统包括导引器，其构造成在脊柱内产生至少69kPa的压力，以及操作器，其配置成致动导引器以根据预定流体导入曲线将流体引入脊柱。 该系统可以包括具有用于接收指示流体引入参数的流体引入数据的代码的计算机可读介质，以及用于在与流体引入数据的时间相关的时间接收表示患者的响应的响应数据。 用于引入流体的方法包括将第一导引器定位在脊柱的第一部分中，将第二导引器定位在脊柱的第二不同部分中，并且不移除第一和第二导引器，将流体引入脊柱的第一部分 与第一导引器一起引入流体到第二引导器到脊柱的第二部分。

    Method For Repairing A Rotator Cuff
    3.
    发明申请
    Method For Repairing A Rotator Cuff 审中-公开
    方法修复旋转器袖带

    公开(公告)号：US20100211174A1

    公开(公告)日：2010-08-19

    申请号：US12694831

    申请日：2010-01-27

    申请人： Nelson Scarborough

    发明人： Nelson Scarborough

    IPC分类号： A61F2/08

    CPC分类号： A61F2/0811 ,  A61B17/0401 ,  A61B2017/00004 ,  A61B2017/0414 ,  A61B2017/044 ,  A61F2002/0858 ,  A61F2002/087 ,  A61F2002/0888

    摘要： A method of repairing a rotator cuff is disclosed. The method includes accessing a surgical site including a humerus and a rotator cuff tendon, debriding the rotator cuff tendon and creating a defect in the humerus. The method further includes providing a bone-tendon assembly including at least one graft tendon and at least one bone segment, attaching the at least one bone segment of the bone-tendon assembly within the bone defect such that the at least one graft tendon extends from the humerus and attaching the at least one graft tendon to the rotator cuff tendon.

    摘要翻译： 公开了一种修复肩袖的方法。 该方法包括进入包括肱骨和肩袖肌腱的外科手术部位，清除肩袖腱并在肱骨中产生缺陷。 所述方法还包括提供包括至少一个移植筋和至少一个骨段的骨 - 肌腱组件，将所述骨腱组件的所述至少一个骨段连接在所述骨缺损内，使得所述至少一个移植腱从 肱骨和将至少一个移植物腱附接到肩袖腱上。

    Osteoimplant and Method for Making Same
    6.
    发明申请
    Osteoimplant and Method for Making Same 有权
    植骨及其制作方法

    公开(公告)号：US20070168030A1

    公开(公告)日：2007-07-19

    申请号：US11676429

    申请日：2007-02-19

    申请人： Jean Edwards ,  Lawrence Shimp ,  Michele Diegmann ,  Todd Boyce ,  Nelson Scarborough ,  James Russell

    发明人： Jean Edwards ,  Lawrence Shimp ,  Michele Diegmann ,  Todd Boyce ,  Nelson Scarborough ,  James Russell

    IPC分类号： A61F2/28 ,  A61F2/44

    CPC分类号： A61L27/3683 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02

    摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.

    摘要翻译： 提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。 根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。

    Flowable composition that hardens on delivery to a target tissue site beneath the skin
    8.
    发明授权
    Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权
    可流动的组合物在皮肤递送至目标组织部位时变硬

    公开(公告)号：US09161903B2

    公开(公告)日：2015-10-20

    申请号：US12262705

    申请日：2008-10-31

    申请人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    发明人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    IPC分类号： A61K51/00 ,  A61K9/00 ,  A61K9/14 ,  A61K47/34

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/16 ,  A61K31/573 ,  A61K47/10 ,  A61K47/34 ,  A61K51/1213

    摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.

    摘要翻译： 提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为 能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位 包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。 在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。