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16 条记录 (耗时 0.013 秒)

    Process for photometric determination of protein C and/or protein S
    1.
    发明授权
    Process for photometric determination of protein C and/or protein S 失效
    蛋白C和/或蛋白S的光度测定方法

    公开(公告)号：US5001069A

    公开(公告)日：1991-03-19

    申请号：US256100

    申请日：1988-10-04

    申请人： Knut Bartl ,  Andreas Dessauer ,  Helmut Lill

    发明人： Knut Bartl ,  Andreas Dessauer ,  Helmut Lill

    IPC分类号： G01N33/68 ,  C12Q1/56 ,  G01N21/78 ,  G01N33/86

    CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N2333/4626 ,  G01N2333/745 ,  G01N2333/96461

    摘要： The present invention provides a process for the photometric determination of protein C and/or protein S activity, especially in plasma, wherein the sample containing the protein C and/or protein S to be determined is incubated with a protein C activator from snake venom with the formation of activated protein C and/or protein S and the decrease of the formation of thrombin from prothrombin brought about by the coagulation factors and the activators thereof is determined by means of a chromogenic thrombin substrate.

    摘要翻译： 本发明提供了一种用于光度测定蛋白C和/或蛋白S活性的方法，特别是在血浆中，其中将待测定的含有蛋白C和/或蛋白S的样品与来自蛇毒的蛋白C激活剂一起温育， 活化蛋白C和/或蛋白S的形成以及由凝血因子及其活化剂引起的凝血酶原形成的凝血酶的形成减少是通过显色凝血酶底物来确定的。

    Analysis element for determination of a coagulation parameter
    6.
    发明授权
    Analysis element for determination of a coagulation parameter 失效
    用于测定凝血参数的分析元素

    公开(公告)号：US4861712A

    公开(公告)日：1989-08-29

    申请号：US046659

    申请日：1987-05-04

    申请人： Knut Bartl ,  Helmut Lill ,  Hans Wielinger

    发明人： Knut Bartl ,  Helmut Lill ,  Hans Wielinger

    IPC分类号： C12Q1/56 ,  C12Q1/00 ,  G01N33/52 ,  G01N33/86

    CPC分类号： G01N33/525 ,  G01N33/86 ,  C12Q2337/12 ,  G01N2333/745 ,  Y10S435/805 ,  Y10S436/81

    摘要： The present invention provides an analysis element for the determination of coagulation parameters with the help of a detectable or a detection reaction-initiating substrate of a protease of the blood coagulation system and at least one factor and/or co-factor of the blood coagulation system and a buffer substance, wherein the factor and/or co-factor, together with a water-soluble, non-ionic polymer which does not falsely influence the course of the coagulation cascade, is impregnated on an open, planar composite structure which consists of a material which does not have a disturbing influence on the course of the coagulation.

    摘要翻译： 本发明提供了一种用于通过凝血系统的蛋白酶的可检测或检测反应引发底物和血液凝固系统的至少一个因子和/或辅因子来确定凝血参数的分析元件 和缓冲物质，其中所述因子和/或辅助因子与不会对凝血级联进程没有错误影响的水溶性非离子聚合物一起浸渍在开放的平面复合结构上，所述平面复合结构由 不会对凝固过程产生干扰的材料。

    Process for determining the perkallikrein content and the partial thromboplastin time of a plasma sample
    7.
    发明授权
    Process for determining the perkallikrein content and the partial thromboplastin time of a plasma sample 失效
    用于测定血浆样品的促凝血素蛋白含量和部分凝血活酶时间的方法

    公开(公告)号：US4732860A

    公开(公告)日：1988-03-22

    申请号：US822364

    申请日：1986-01-24

    申请人： Knut Bartl ,  Helmut Lill

    发明人： Knut Bartl ,  Helmut Lill

    IPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N21/78

    CPC分类号： C12Q1/56 ,  C12Q2337/12 ,  G01N2333/96455

    摘要： The present invention provides a process for the photometric determination of prekallikrein in plasma, wherein plasma is incubated with a surface activator, the extinction obtained is measured, a chromogenic thrombin substrate is then added thereto, the optically determinable group liberated therefrom is measured at short time intervals or continuously and the gradient of the linear part of the curve obtained by plotting the time against the extinction is determined as a measure of the prekallikrein content. The partial thromboplastin time of plasma is simultaneously determined by carrying out the incubation in the presence of calcium ions and a phospholipid and measuring the time it takes the extinction to reach a predetermined level.

    摘要翻译： 本发明提供了一种用于光度测定血浆中前激肽释放酶的方法，其中将血浆与表面活化剂一起温育，测量所得的消光，然后向其中加入显色凝血酶底物，在短时间内测定从其释放的光学上可测定的基团 间隔或连续，并且通过绘制针对灭绝的时间获得的曲线的线性部分的梯度被确定为前激肽释放素含量的量度。 通过在钙离子和磷脂的存在下进行孵育并测量灭绝达到预定水平的时间，同时测定血浆的部分凝血活酶时间。