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公开(公告)号：US06852705B2
公开(公告)日：2005-02-08
申请号：US09766442
申请日：2001-01-19
CPC分类号： A61K47/24 , A61K9/0019 , A61K39/39 , A61K47/186 , A61K2039/53 , A61K2039/55511
摘要： Improved vaccines or immunogenic or immunological compositions, and methods for making and using the same.
摘要翻译： 改进的疫苗或免疫原性或免疫组合物，以及制备和使用它们的方法。
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公开(公告)号：US07078388B2
公开(公告)日：2006-07-18
申请号：US09760574
申请日：2001-01-16
IPC分类号： A61K48/00
CPC分类号： A61K47/24 , A61K9/0019 , A61K39/39 , A61K47/186 , A61K2039/53 , A61K2039/55511 , Y10S424/813
摘要： DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal species considered, under conditions allowing the in vivo expression of this sequence, and a cationic lipid containing a quaternary ammonium salt, of formula in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is another aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group, this lipid being preferably DMRIE.
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公开(公告)号：US08871225B2
公开(公告)日：2014-10-28
申请号：US12839580
申请日：2010-07-20
IPC分类号： A61K39/008 , C07H21/04 , A61K39/00
CPC分类号： A61K39/008 , A61K2039/53 , A61K2039/545 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供含有体内利什曼原虫KMP11或其表位的载体，其在狗中针对利什曼原虫引起免疫应答，包含所述载体的组合物，针对利什曼原虫接种的方法，以及用于此类方法和组合物的试剂盒。
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公开(公告)号：US08097599B2
公开(公告)日：2012-01-17
申请号：US12794184
申请日：2010-06-04
IPC分类号： C12N15/00
CPC分类号： C07K14/51 , A61K38/1875 , A61K48/005 , A61K48/0075 , C12N15/85 , C12N2800/107
摘要： The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
摘要翻译： 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过血管内肾脏给予本发明的重组载体和药物组合物来预防和/或治疗哺乳动物，有利地在人，狗和猫中的急性和慢性肾功能衰竭的方法。
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公开(公告)号：US20100285066A1
公开(公告)日：2010-11-11
申请号：US12839580
申请日：2010-07-20
IPC分类号： A61K39/008 , A61P33/02
CPC分类号： A61K39/008 , A61K2039/53 , A61K2039/545 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供含有体内利什曼原虫KMP11或其表位的载体，其在狗中针对利什曼原虫引起免疫应答，包含所述载体的组合物，针对利什曼原虫疫苗接种的方法，以及用于此类方法和组合物的试剂盒。
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公开(公告)号：US20080269150A1
公开(公告)日：2008-10-30
申请号：US11803991
申请日：2007-05-16
IPC分类号： A61K31/7088 , C12N15/64 , A61P13/12
CPC分类号： C07K14/51 , A61K38/1875 , A61K48/005 , A61K48/0075 , C12N15/85 , C12N2800/107
摘要： The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
摘要翻译： 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过血管内肾脏给予本发明的重组载体和药物组合物来预防和/或治疗哺乳动物，有利地在人，狗和猫中的急性和慢性肾功能衰竭的方法。
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7.发明申请公开(公告)号：US20120093841A1
公开(公告)日：2012-04-19
申请号：US13272651
申请日：2011-10-13
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/53 , A61K2039/545
摘要： The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.
摘要翻译： 该申请公开了基于表达编码大鼠Her2蛋白的基因的“pING”DNA质粒载体的治疗性疫苗。 根据本公开的疫苗被用作用于具有过表达Her2抗原的癌症的狗和猫的手术，放射和/或化学疗法的辅助治疗，并且延长了手术后无疾病间隔和/或存活时间。 还包括使用所述疫苗的治疗有效的免疫方法。
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公开(公告)号：US20100261782A1
公开(公告)日：2010-10-14
申请号：US12794184
申请日：2010-06-04
CPC分类号： C07K14/51 , A61K38/1875 , A61K48/005 , A61K48/0075 , C12N15/85 , C12N2800/107
摘要： The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.
摘要翻译： 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过血管内肾脏给予本发明的重组载体和药物组合物来预防和/或治疗哺乳动物，有利地在人，狗和猫中的急性和慢性肾功能衰竭的方法。
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公开(公告)号：US20080241193A1
公开(公告)日：2008-10-02
申请号：US11942457
申请日：2007-11-19
CPC分类号： A61K39/008 , A61K2039/53 , A61K2039/545 , Y02A50/41
摘要： The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.
摘要翻译： 本发明提供含有体内利什曼原虫KMP11或其表位的载体，其在狗中针对利什曼原虫引起免疫应答，包含所述载体的组合物，针对利什曼原虫接种的方法，以及用于此类方法和组合物的试剂盒。
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10.发明授权Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure 有权嵌合KSAC蛋白的表达及其制备高可溶性蛋白质的方法公开(公告)号：US09315553B2
公开(公告)日：2016-04-19
申请号：US14014437
申请日：2013-08-30
IPC分类号： C12P21/04 , C12N5/00 , C12N5/02 , C12N1/00 , C12N1/12 , C12N1/20 , C07K14/245 , A23L3/015 , A61K39/008 , A61K39/02 , A61L2/00 , C12N9/10 , C12N9/52 , C07K14/44 , C12P21/02 , A61K39/00
CPC分类号： C07K14/44 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/245 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
摘要： The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
摘要翻译： 本发明包括含有具有免疫原性和保护性质的嵌合KSAC蛋白质的疫苗或组合物，以及使用方法，包括向动物施用其抗原性KSAC蛋白质以保护动物。 本发明还包括从由原核生物或真核生物产生的包涵体制备和产生可溶，分解，重折叠或活性蛋白的方法。
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