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公开(公告)号：US12064544B2
公开(公告)日：2024-08-20
申请号：US16906976
申请日：2020-06-19
发明人： Dennis Briggs , Simon Do , Eric Rabeno , Abdoulaye Sangare , Mark Vandlik , Vicki Fluck , Christopher Turek
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/3609 , A61M1/36222 , A61M1/36225 , A61M1/362264 , A61M1/362266 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3652 , A61M1/3683 , A61M2202/0439 , A61M2205/051 , A61M2205/053 , A61M2205/3331 , A61M2205/3334 , A61M2205/6018 , A61M2230/207 , G01M3/26
摘要： A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200).
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公开(公告)号：US11992620B2
公开(公告)日：2024-05-28
申请号：US15854643
申请日：2017-12-26
发明人： Jim Potenziano , Joe Stauffer
CPC分类号： A61M16/12 , A61K33/00 , A61M16/0096 , G16H10/20 , G16H50/30 , A61M2016/1035 , A61M2202/0208 , A61M2202/025 , A61M2202/0275 , Y02A90/10
摘要： Disclosed are methods of treatment that permit a reduction of risk of mortality in infants who are candidates for treatment with inhaled nitric oxide, by identifying a subset of such infants who are at an increased risk of mortality upon treatment with inhaled nitric oxide; also disclosed are related systems for use in administering inhaled nitric oxide and methods of distributing a pharmaceutical product.
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公开(公告)号：US11660416B2
公开(公告)日：2023-05-30
申请号：US16785983
申请日：2020-02-10
CPC分类号： A61M16/12 , A61K33/00 , A61M16/024 , A61M16/06 , A61M16/202 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2202/0275 , A61M2205/3334 , A61M2205/50 , A61M2205/502
摘要： Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
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公开(公告)号：US10894140B2
公开(公告)日：2021-01-19
申请号：US15281512
申请日：2016-09-30
发明人： John C. Falligant , Craig R. Tolmie
摘要： Systems and methods of the present invention can enable high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.
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公开(公告)号：US10661045B2
公开(公告)日：2020-05-26
申请号：US15204176
申请日：2016-07-07
发明人： Duncan P. Bathe , John Klaus , David Christensen
IPC分类号： A61M16/20 , A61M16/08 , A61M16/00 , A61M16/12 , A61M16/10 , A61M16/04 , A61M16/06 , A61M16/16
摘要： A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gases containing nitric oxide are also described.
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公开(公告)号：US20200155777A1
公开(公告)日：2020-05-21
申请号：US16748319
申请日：2020-01-21
发明人： Jaron M. Acker , Jeff Milsap , Robin Roehl , Jeffrey Schmidt , Craig R. Tolmie
摘要： Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
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公开(公告)号：US20200094010A1
公开(公告)日：2020-03-26
申请号：US16696142
申请日：2019-11-26
发明人： Jaron Acker , Muhammad Asif , Craig Flanagan , Douglas Alan Greene , Sarah Jayne Ridley , Frank Kenneth Schweighardt , Lien-Lung Sheu
摘要： The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO2, and providing an indication of the remaining useful life and/or break-through.
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公开(公告)号：US20200046798A1
公开(公告)日：2020-02-13
申请号：US16669151
申请日：2019-10-30
IPC分类号： A61K38/095 , G01N33/49 , G01N15/10 , A61M27/00 , A61K45/06 , A61K38/38 , A61K9/00 , A61B5/145 , A61B5/0205
摘要： The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC 12 cells/4; HR>90 bpm; and any one of HCO3 20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
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公开(公告)号：US10478584B2
公开(公告)日：2019-11-19
申请号：US15420689
申请日：2017-01-31
发明人： Jaron M. Acker , Craig R. Tolmie
摘要： The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.
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公开(公告)号：US10426913B2
公开(公告)日：2019-10-01
申请号：US13800287
申请日：2013-03-13
发明人： Craig R. Tolmie , Robert Schnitman , Joseph J. Medicis , Jim Potenziano , Jaron Acker , Jeffrey Schmidt
摘要： Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
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