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1.发明申请公开(公告)号：US20070108128A1
公开(公告)日：2007-05-17
申请号：US10580869
申请日：2004-09-11
Applicant: Pascal Kopperschmidt , Malte Gross
Inventor： Pascal Kopperschmidt , Malte Gross
IPC: B01D61/32
CPC classification number: A61M1/3441 , A61M1/3434 , A61M1/3437 , A61M1/3609 , A61M1/3639 , A61M2230/207
Abstract: A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.
Abstract translation: 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。
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2.发明授权Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis 有权用于监测患者治疗的方法和装置，优选用于监测血液透析，血液透析滤过和/或腹膜透析公开(公告)号：US09215985B2
公开(公告)日：2015-12-22
申请号：US14111248
申请日：2012-04-10
Applicant: Malte Gross , Pascal Kopperschmidt , Andreas Maierhofer , Alfred Gagel
Inventor： Malte Gross , Pascal Kopperschmidt , Andreas Maierhofer , Alfred Gagel
CPC classification number: A61B5/0082 , A61B5/0071 , A61B5/0075 , A61B5/14546 , A61B5/14557 , A61M1/367 , G01N21/6486 , G01N21/65
Abstract: A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.
Abstract translation: 一种监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，其包括以下步骤：用至少第一照射波长的照射光照射用于治疗的透析液样品，检测 由至少第一检测波长的被照射样品发射的光，检测波长不同于第一照射波长，并且基于检测到的光来确定样品中至少一种分析物的存在和/或浓度。
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公开(公告)号：US08439857B2
公开(公告)日：2013-05-14
申请号：US13130116
申请日：2009-11-14
Applicant: Pascal Kopperschmidt , Malte Gross , Reiner Spickermann
Inventor： Pascal Kopperschmidt , Malte Gross , Reiner Spickermann
CPC classification number: A61B5/02042 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/18 , A61M2205/3331
Abstract: A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line is provided. A device for extracorporeal blood treatment comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extracorporeal blood treatment. One aspect of the method and the device is that pressure changes that come from a pressure level exhibiting a large difference from a reference value are more strongly considered than those that come from a pressure level that exhibits only a minor difference from the reference value.
Abstract translation: 提供了一种方法和装置，用于在通过管线向血管通路供血时和/或通过管线从血管通路中取出血液来供应血液，以识别旁路出血。 还提供了一种用于体外血液处理的装置，其包括用于识别paravasal出血的装置。 该方法和装置基于在体外血液处理期间记录的动脉分支中的动脉压的变化或在体外循环的静脉分支中的静脉压。 该方法和装置的一个方面是，从与参考值相比仅显示较小差异的压力水平的压力水平的压力变化更强烈地考虑来自与参考值的差异较大的压力水平的压力变化。
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4.发明申请METHOD AND APPARATUS FOR MONITORING A TREATMENT OF A PATIENT, PREFERABLY FOR MONITORING HEMODIALYSIS, HEMODIAFILTRATION, AND/OR PERITONEAL DIALYSIS 有权用于监测患者的方法和装置，用于监测HEMODIALYSIS，HEMODIAFILTRATION和/或PERITONEAL DIALYSIS公开(公告)号：US20140098359A1
公开(公告)日：2014-04-10
申请号：US14111248
申请日：2012-04-10
Applicant: Malte Gross , Pascal Kopperschmidt , Andreas Malerhofer , Alfred Gagel
Inventor： Malte Gross , Pascal Kopperschmidt , Andreas Malerhofer , Alfred Gagel
CPC classification number: A61B5/0082 , A61B5/0071 , A61B5/0075 , A61B5/14546 , A61B5/14557 , A61M1/367 , G01N21/6486 , G01N21/65
Abstract: The present invention pertains to a method for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, the method comprising the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.
Abstract translation: 本发明涉及一种用于监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，所述方法包括以下步骤：将用于治疗的透析液样品至少照射至少 第一照射波长，检测由至少第一检测波长的被照射样品发射的光，检测波长与第一照射波长不同，并且基于该基准确定样品中至少一种分析物的存在和/或浓度 的检测光。
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5.发明授权公开(公告)号：US08460552B2
公开(公告)日：2013-06-11
申请号：US10580869
申请日：2004-09-11
Applicant: Pascal Kopperschmidt , Malte Gross
Inventor： Pascal Kopperschmidt , Malte Gross
CPC classification number: A61M1/3441 , A61M1/3434 , A61M1/3437 , A61M1/3609 , A61M1/3639 , A61M2230/207
Abstract: A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.
Abstract translation: 一种方法和装置，其使用体外血液透析装置来识别血液体外处理期间体外血液回路中的血流的损伤，其中振荡压力信号的至少一次谐波振荡在体外传播的相位角 确定血液回路。 基于对压力信号的至少一次谐波振荡的相位角的特征修改，在体外血液回路中检测出血流的损伤。 可以将相位角的时间修改与预定义的阈值进行比较，并且如果相位角的修改值大于预定阈值，则检测损伤。 该方法和装置允许早期鉴定血液透析装置中血液的凝结，从而可以及时启动对策。
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Patent Agency Ranking
6.发明授权Device and method for determining and controlling the concentration of at least one solute in a fluid circuit 有权用于确定和控制流体回路中至少一种溶质的浓度的装置和方法公开(公告)号：US08764987B2
公开(公告)日：2014-07-01
申请号：US13262407
申请日：2010-03-31
Applicant: Malte Gross , Andreas Maierhofer
Inventor： Malte Gross , Andreas Maierhofer
CPC classification number: A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/3609 , A61M2205/3317 , A61M2205/3324 , A61M2205/502 , A61M2205/52 , A61M2230/65
Abstract: An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.
Abstract translation: 一种用于确定和调节流体回路中至少一种溶解物质的浓度的装置和方法，其中，所述流体回路包括以半渗透方式由过滤器隔开的至少两个部分回路，包括检测单元 用于确定至少一种第一溶解物质的浓度差的确定单元，用于确定与所述至少一种第一溶解物质不同的至少一种第二溶解物质的影响的判定单元，以及用于调节所述至少一种溶解物质浓度的调节单元 至少一种溶解物质在流体回路中。
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7.发明授权公开(公告)号：US08784353B2
公开(公告)日：2014-07-22
申请号：US13123290
申请日：2009-10-02
Applicant: Andreas Maierhofer , Malte Gross
Inventor： Andreas Maierhofer , Malte Gross
CPC classification number: A61M1/367 , A61M1/3656 , A61M1/3663 , A61M39/10 , A61M39/105 , A61M39/1055 , A61M39/22 , A61M39/223 , A61M2039/1044 , A61M2039/229 , A61M2205/3515 , A61M2205/3561 , A61M2205/3569 , A61M2205/6018 , A61M2205/6054 , F16K11/074
Abstract: A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.
Abstract translation: 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。
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8.发明申请DEVICE FOR REVERSING THE BLOOD FLOW FOR AN EXTRACORPOREAL BLOOD TREATMENT DEVICE AND METHOD FOR DETERMINING THE REVERSAL OF THE BLOOD FLOW DURING AN EXTRACORPOREAL BLOOD TREATMENT 有权用于逆转血液流量的装置用于外部血液治疗装置和用于确定在血液内血液治疗期间血液循环逆转的方法公开(公告)号：US20110196279A1
公开(公告)日：2011-08-11
申请号：US13123290
申请日：2009-10-02
Applicant: Andreas Maierhofer , Malte Gross
Inventor： Andreas Maierhofer , Malte Gross
IPC: A61M1/14
CPC classification number: A61M1/367 , A61M1/3656 , A61M1/3663 , A61M39/10 , A61M39/105 , A61M39/1055 , A61M39/22 , A61M39/223 , A61M2039/1044 , A61M2039/229 , A61M2205/3515 , A61M2205/3561 , A61M2205/3569 , A61M2205/6018 , A61M2205/6054 , F16K11/074
Abstract: A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.
Abstract translation: 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。
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9.发明申请DEVICE AND METHOD FOR MONITORING AN ACCESS TO A PATIENT, IN PARTICULAR A VASCULAR ACCESS DURING AN EXTRACORPOREAL BLOOD TREATMENT 审中-公开用于监测患者，特别是血液透析过程中的血液通透途径的装置和方法公开(公告)号：US20110046534A1
公开(公告)日：2011-02-24
申请号：US12920636
申请日：2009-03-03
Applicant: Malte Gross
Inventor： Malte Gross
CPC classification number: A61M1/367 , A61M5/158 , A61M2005/1588 , A61M2205/15
Abstract: The invention relates to the monitoring of an access to a patient at a puncture point, in particular the monitoring of the arterial and/or venous vascular access during an extracorporeal blood treatment. The device according to the invention is a magnetoelastic moisture sensor, which is embedded in an absorbent material and is laid on the puncture point. For the case in which infusion solution and/or blood exits from the puncture point, the incorrect seating of the puncture cannula can be recognized reliably using the device according to the invention. The absorbent material having the embedded magnetoelastic moisture sensor can be laid like conventional bandage material or a gauze bandage on the puncture point.
Abstract translation: 本发明涉及在穿刺点处对病人的进入的监测，特别是在体外血液处理期间监测动脉和/或静脉血管通路。 根据本发明的装置是一种磁弹性水分传感器，其被嵌入吸收材料中并铺设在穿刺点上。 对于输液和/或血液从穿刺点离开的情况，可以使用根据本发明的装置可靠地识别穿刺套管的错位。 具有嵌入式磁弹性湿度传感器的吸收材料可以像传统的绷带材料或纱布绷带放置在穿刺点上。
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10.发明授权Method for determining a treatment parameter on a haemofiltration device, and haemofiltration device for applying the method 有权用于确定血液净化装置上的治疗参数的方法和用于应用该方法的血液净化装置公开(公告)号：US06939471B2
公开(公告)日：2005-09-06
申请号：US10393361
申请日：2003-03-21
Applicant: Malte Gross , Andreas Maierhofer
Inventor： Malte Gross , Andreas Maierhofer
CPC classification number: A61M1/16 , A61M1/1603 , A61M1/1613 , A61M1/1654 , A61M1/1656 , A61M1/361 , A61M2202/0498 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/52
Abstract: A method for determining a treatment parameter on a haemofiltration device, as well as a haemofiltration device for applying the method, based on the recognition that a determination method known from haemodialysis can, with little modification, be transferred to haemofiltration. To this effect a physical-chemical characteristic of the substitution fluid and of the fluid which is removed from the haemofilter by way of an ultrafiltrate outlet pipe, is determined. Furthermore, this characteristic is acquired before, after or during a change of this characteristic in the substitution fluid, and is evaluated. As a result, the ion dialysance and thus the urea clearance of a haemofiltration device, which can also be operated as a haemodiafiltration device, can be determined.
Abstract translation: 基于认识到从血液透析已知的测定方法可以很少改进的方法转移到血液过滤中，用于确定血液净化装置上的治疗参数以及用于应用该方法的血液净化装置的方法。 为此，确定了取代流体和通过超滤出口管从除污机除去的流体的物理化学特性。 此外，在替代液中的该特性的变化之前，之后或期间获取该特性，并进行评价。 结果，可以确定也可以作为血液透析过滤装置操作的血液净化装置的离子透析性以及因此的尿素清除率。
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