摘要:
The invention relates to a nucleic acid aptamer with the capability of binding specifically to a and inhibiting TLR-4, to a complex comprising said aptamer and a functional group, as well as to pharmaceutical compositions thereof. The invention also relates to uses and methods for detecting TLR-4 and to uses and methods for inhibiting TLR-4. Finally, the invention also relates to an aptamer for use in manufacturing a drug for the treatment of a pathology characterized by an increase in expression of TLR4 and/or an increase in activation of TLR-4.
摘要:
The present invention is about a volume-measuring device installed inside a box that used to store a liquid. The measuring device is placed at the bottom of the box dispensing the liquid, and displays via a measuring tower a measure of the volume of the liquid still in the box. The device is comprised of a receptacle or sealed pouch connected to a measuring tower. As the pressure from the weight of the liquid changes, the receptacle reacts by moving the measuring marker to reflect such change, thus measuring the current liquid volume in the dispensing box.
摘要:
Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant.
摘要:
The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by detecting and/or quantifying the protein Ganglioside GM2 Activator Protein (GM2AP). The failure can be due to the administration of at least one nephrotoxic agent, wherein the nephrotoxic agent can be an aminoglycoside antibiotic as for example gentamicin.
摘要:
An assembly (30) controls the amount of downward movement of a counterweight (24) within an elevator system (20). By limiting the downward movement of the counterweight (24), a desired overhead clearance above an elevator car (22) can be maintained. One example includes at least one safety device (80, 84, 86, 88) on top of the elevator car (22) to provide an indication for when a holding member (34) should allow a stop member of the assembly (30) to move into a position to limit the downward movement of the counterweight (24). In one example, the stop member (32) moves into an employed position by the force of gravity and is manually moveable back into a retracted position when it is not needed. One example includes a guide member (60) that facilitates controlling the position of the stop member (32) when it is in the employed position.
摘要:
In a process for the production of an aircraft stop by molding a composite material of resin and carbon fibers, a stack of pieces made of composite material, in which a metal piece will have been inserted, is draped by superposing layers of carbon fibers that are preimpregnated with resin, whereby the fibers are oriented so as to ensure maximum cohesion of the unit around the metal piece (4).
摘要:
Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising said cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.
摘要:
The present invention provides an apparatus and method of orienting perforating gun strings. One embodiment of the present invention provides an orienting weight provided in a portion of the perforating device, such as the shaped charge, the loading tube or the gun housing. Additional weight may be provided as separate components and attached to the gun components.
摘要:
A hand held power tool having a non-removable handle. The handle may be positioned in two or more fixed positions during operation of the hand held power tool.
摘要:
A system to decrease the World Wide Web network usage at peak hours by clients requesting viewing of videos. The system will use a video content server and a software application running on a client's computer. The software application will schedule at off peak hours the pre-load of videos for the client. The selection of the pre-load list of videos will be calculated between the video content server and the software application based on the client's past behavior of video selections, and the current list of most popular videos available in the video content server. The pre-load videos will be stored at a client local storage. Whenever the client wants to watch videos a list of the pre-loaded videos will be presented and all selections done by the client on this list will save World Wide Web network peak hour utilization.