公开(公告)号：US20110177082A1

公开(公告)日：2011-07-21

申请号：US13009413

申请日：2011-01-19

申请人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

发明人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K14/00 ,  C07K7/00 ,  C07K16/00 ,  A61K31/7088 ,  A61K38/00 ,  A61K35/12 ,  A61K39/00 ,  A61P35/00 ,  C12N15/63 ,  G01N33/68 ,  C12N5/0783 ,  G01N33/53 ,  G01N33/566 ,  C12N1/00 ,  C12N5/10

CPC分类号： C07K16/3069 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/4748 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US20080226643A1

公开(公告)日：2008-09-18

申请号：US11929833

申请日：2007-10-30

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K9/00 ,  C07K14/00 ,  C12N15/64 ,  C12Q1/68 ,  C12N5/08 ,  C07K16/00 ,  G01N33/53 ,  C07K19/00 ,  A61P35/00

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2319/00 ,  C12Q1/6886

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US07074898B2

公开(公告)日：2006-07-11

申请号：US10010940

申请日：2001-12-05

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022 ,  C12N2760/16222

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06630574B1

公开(公告)日：2003-10-07

申请号：US09614124

申请日：2000-07-11

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： A61K3816

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.

摘要翻译： 公开了包含分离的癌相关L552S多肽的组合物。 这样的组合物可以包括例如所述癌相关L552S多肽的部分和/或编码这些部分的相应多核苷酸。 还提供了组合物的说明性用途，例如癌症诊断方法。

公开(公告)号：US06620922B1

公开(公告)日：2003-09-16

申请号：US09636215

申请日：2000-08-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US07935338B2

公开(公告)日：2011-05-03

申请号：US10317747

申请日：2002-12-11

申请人： Gary R. Fanger ,  Neil Fanger ,  David King ,  Marc W. Retter ,  Kenneth L. Rock

发明人： Gary R. Fanger ,  Neil Fanger ,  David King ,  Marc W. Retter ,  Kenneth L. Rock

IPC分类号： A61K39/395

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732

摘要： Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.

摘要翻译： 公开了用于治疗癌症，特别是黑素瘤，骨髓瘤，小细胞肺癌，胸腺淋巴瘤，T细胞淋巴瘤，B细胞淋巴瘤，骨肉瘤和急性T细胞白血病的组合物和方法。 说明性组合物包括一种或多种编码这种抗神经节苷脂抗体的抗神经节苷脂抗体和多核苷酸。 这些抗体可以是例如仓鼠抗体，嵌合人/仓鼠抗体或人源化抗体。 所公开的组合物可用于例如治疗癌症，并可用于诱导癌细胞中的细胞凋亡。

公开(公告)号：US07517952B1

公开(公告)日：2009-04-14

申请号：US09593793

申请日：2000-06-13

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07K14/00 ,  A61K39/00 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/565

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20080311109A1

公开(公告)日：2008-12-18

申请号：US11929835

申请日：2007-10-30

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

IPC分类号： A61K35/12 ,  C07H21/04 ,  C12N15/63 ,  C12N5/06 ,  C07K16/00 ,  C07K2/00 ,  G01N33/53 ,  C12Q1/68 ,  A61P35/00 ,  C07K14/00 ,  C12N5/08 ,  A61K38/02 ,  A61K31/711 ,  A61K39/395 ,  A61K38/16

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2319/00 ,  C12Q1/6886

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US07425607B2

公开(公告)日：2008-09-16

申请号：US11301554

申请日：2005-12-13

申请人： Robert A Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D Kalos ,  Paul R Sleath ,  Jeffrey C Johnson ,  Marc W Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R Fanger ,  Thomas S Vedvick ,  Chaitanya S Bangur ,  Andria McNabb

发明人： Robert A Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D Kalos ,  Paul R Sleath ,  Jeffrey C Johnson ,  Marc W Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R Fanger ,  Thomas S Vedvick ,  Chaitanya S Bangur ,  Andria McNabb

IPC分类号： A61K38/00 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

公开(公告)号：US07202342B1

公开(公告)日：2007-04-10

申请号：US09570737

申请日：2000-05-12

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/3069 ,  C07K2317/34

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。