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公开(公告)号：US20080171690A1
公开(公告)日：2008-07-17
申请号：US11929579
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US20080292633A1
公开(公告)日：2008-11-27
申请号：US11929565
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C12N15/00 , C12N5/00 , A61K35/12 , C07K16/00 , G01N33/574 , C12N5/02
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US20080171048A1
公开(公告)日：2008-07-17
申请号：US11929572
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US07425607B2
公开(公告)日：2008-09-16
申请号：US11301554
申请日：2005-12-13
申请人： Robert A Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D Kalos , Paul R Sleath , Jeffrey C Johnson , Marc W Retter , Margarita Durham , Darrick Carter , Gary R Fanger , Thomas S Vedvick , Chaitanya S Bangur , Andria McNabb
发明人： Robert A Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D Kalos , Paul R Sleath , Jeffrey C Johnson , Marc W Retter , Margarita Durham , Darrick Carter , Gary R Fanger , Thomas S Vedvick , Chaitanya S Bangur , Andria McNabb
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US06858204B2
公开(公告)日：2005-02-22
申请号：US10017754
申请日：2001-10-29
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US06504010B1
公开(公告)日：2003-01-07
申请号：US09702705
申请日：2000-10-30
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： C07K14435
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US06630574B1
公开(公告)日：2003-10-07
申请号：US09614124
申请日：2000-07-11
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： A61K3816
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions comprising isolated cancer-associated L552S polypeptides are disclosed. Such compositions can comprise, for example, portions of said cancer-associated L552S polypeptides and/or the corresponding polynucleotides encoding such portions. Illustrative uses of the compositions, for example in cancer diagnostic methods, are also provided.
摘要翻译： 公开了包含分离的癌相关L552S多肽的组合物。 这样的组合物可以包括例如所述癌相关L552S多肽的部分和/或编码这些部分的相应多核苷酸。 还提供了组合物的说明性用途，例如癌症诊断方法。
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公开(公告)号：US07033827B2
公开(公告)日：2006-04-25
申请号：US10144678
申请日：2002-05-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher , Ta Deng
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher , Ta Deng
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C07K2319/00 , C12N9/6424 , C12N2710/14143 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。
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公开(公告)号：US06943236B2
公开(公告)日：2005-09-13
申请号：US10012896
申请日：2001-12-10
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/11 , C07K14/47 , C07K14/705 , C07K16/30 , C12N9/64 , C07K14/00 , C07H21/02 , C12Q1/68 , C12N1/20
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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公开(公告)号：US06667154B1
公开(公告)日：2003-12-23
申请号：US09671325
申请日：2000-09-26
申请人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
发明人： Tongtong Wang , Chaitanya S. Bangur , Michael J. Lodes , Gary R. Fanger , Thomas S. Vedvick , Darrick Carter , Marc W. Retter , Jane Mannion , Liqun Fan
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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