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公开(公告)号：US5066817A
公开(公告)日：1991-11-19
申请号：US516304
申请日：1990-04-30
申请人： Hirofumi Nakano , Mitsunobu Hara , Tsuyoshi Mokudai , Isao Kawamoto , Mayumi Yoshida , Eiji Kobayashi
发明人： Hirofumi Nakano , Mitsunobu Hara , Tsuyoshi Mokudai , Isao Kawamoto , Mayumi Yoshida , Eiji Kobayashi
IPC分类号： C07D407/04 , C12P17/06
CPC分类号： C07D407/04 , C12P17/06 , Y10S435/886
摘要： Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.
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公开(公告)号：US4914198A
公开(公告)日：1990-04-03
申请号：US946842
申请日：1986-12-29
申请人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
发明人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
摘要翻译： 通过培养微生物产生的新物质UCY1003具有以下化学结构和镇痛，降血压和抗真菌活性：
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公开(公告)号：US5082857A
公开(公告)日：1992-01-21
申请号：US612317
申请日：1990-11-13
申请人： Hirofumi Nakano , Mitsunobu Hara , Yohichi Uosaki , Isao Kawamoto , Keiiechi Takahashi , Katsushige Gomi
发明人： Hirofumi Nakano , Mitsunobu Hara , Yohichi Uosaki , Isao Kawamoto , Keiiechi Takahashi , Katsushige Gomi
CPC分类号： C07D493/04 , C12P17/06
摘要： The present invention relates to a compound designated "DC114-C" having excellent anti-bacterial and anti-tumor activities. This compound may be obtained by fermentation of a microorganism of the genus Streptomyces, preferably Streptomyces sp. DO-114 (FERM BP-2641).
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公开(公告)号：US5101038A
公开(公告)日：1992-03-31
申请号：US458543
申请日：1989-12-28
申请人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
发明人： Hirofumi Nakano , Isami Takahashi , Isao Kawamoto , Toru Yasuzawa , Keiichi Takahashi , Eiji Kobayashi
IPC分类号： A61K31/40 , A61P35/00 , C07D487/04 , C07D487/10 , C12N1/20 , C12P17/18 , C12R1/465
CPC分类号： C07D487/10 , C12P17/182
摘要： A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.
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公开(公告)号：US06194195B1
公开(公告)日：2001-02-27
申请号：US09181083
申请日：1998-10-27
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C12N120
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
摘要翻译： 本发明涉及链霉菌属的生物纯培养物。 RE-701（FERM BP-3624）和Streptomyces sp。 产生内皮素拮抗肽的RE-629（FERM BP-4126）。
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公开(公告)号：US5639860A
公开(公告)日：1997-06-17
申请号：US321625
申请日：1994-10-12
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1021 , C07K5/1024 , C07K7/08
摘要： Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.These peptides have endothelin-antagonizing activity, and are useful for treating hypertension, asthma, cerebral apoplexy, angina pectoris, acute renal failure, cardiac infarction and cerebral vasospasm.
摘要翻译： 由下式（I）表示的肽：其中A表示Asn或Asp; B代表His或Lys; E表示Ala或Ser; （1）将X1和Y1组合在一起形成单键作为X1-Y1，或（2）X1表示氢，Y1表示羟基; 而在（1）的情况下，Z表示Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z1 Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1， Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1，Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z1，Trp- Phe-Phe-Asn-Tyr-RT-Z1，其中Z1是有机部分，其中R是Tyr或共价键，T是Trp，Ala，Phe，Tyr，Trp-Trp，Asn-Tyr-Tyr-Trp，Trp -Tn-Tyr-Tyr-Trp，Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp，或在（2）的情况下，Z表示Trp-Val-Tyr-Phe-Ala -His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Leu-Tyr-Phe-Ala-His-Gln -Asp-Val-Ile-Trp-Z1。 这些肽具有内皮素拮抗作用，可用于治疗高血压，哮喘，脑中风，心绞痛，急性肾功能衰竭，心肌梗死和脑血管痉挛。
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公开(公告)号：US5081264A
公开(公告)日：1992-01-14
申请号：US584278
申请日：1990-09-18
申请人： Shinichiro Toki , Mika Nozawa , Mayumi Yoshida , Hiroshi Sano , Katsuhiko Ando , Isao Kawamoto , Yuzuru Matsuda , Junichi Ikeda , Kazuhiro Kubo
发明人： Shinichiro Toki , Mika Nozawa , Mayumi Yoshida , Hiroshi Sano , Katsuhiko Ando , Isao Kawamoto , Yuzuru Matsuda , Junichi Ikeda , Kazuhiro Kubo
IPC分类号： C12P17/06 , A61K31/35 , A61K31/352 , A61P9/10 , A61P25/18 , A61P25/28 , C07D311/92 , C12P17/16 , C12R1/645
CPC分类号： C12P17/162 , C07D311/92
摘要： A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.The compounds are capable of protecting the nerve cells and also antagonistic activity against N-methyl-D-aspartic acid receptors.They may be prepared by fermentation of a microorganism of the genus Verticillium or a mutant thereof.
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公开(公告)号：US06642355B2
公开(公告)日：2003-11-04
申请号：US09750754
申请日：2001-01-02
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C07K700
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或 其药学上可接受的盐。
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公开(公告)号：US4935415A
公开(公告)日：1990-06-19
申请号：US28201
申请日：1987-03-20
申请人： Hirofumi Nakano , Isami Takahashi , Tatsuya Tamaoki , Fusao Tomita , Isao Kawamoto , Kozo Asano , Makoto Morimoto , Hisayo Nomoto
发明人： Hirofumi Nakano , Isami Takahashi , Tatsuya Tamaoki , Fusao Tomita , Isao Kawamoto , Kozo Asano , Makoto Morimoto , Hisayo Nomoto
IPC分类号： A61K31/55 , A61P31/04 , A61P35/00 , C07D498/22 , C07H9/06 , C07H19/044 , C12P17/18 , C12R1/465
CPC分类号： C07H9/06 , C07H19/044 , C12P17/18 , C12P17/188 , C12R1/465 , Y10S435/886 , Y10S514/908
摘要： UCN-01 having an anti-tumor activity and an anti-bacterial activity is produced by culturing a microorganism belonging to the genus Streptomyces.
摘要翻译： 通过培养属于链霉菌属的微生物来产生具有抗肿瘤活性和抗细菌活性的UCN-01。
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10.发明授权Pyrindamycins A and B and duocarmycin A antibiotics derived from certain streptomyces culture 失效来自某些链霉菌培养物的青霉素A和B以及二焦霉素A抗生素
公开(公告)号：US4923990A
公开(公告)日：1990-05-08
申请号：US242788
申请日：1988-09-09
申请人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
发明人： Hirofumi Nakano , Isami Takahashi , Michio Ichimura , Isao Kawamoto , Kozo Asasno , Fusao Tomita , Hiroshi Sano , Toru Yasuzawa , Makoto Morimoto , Kazuhisa Fujimoto
CPC分类号： C12P1/06
摘要： The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.
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