公开(公告)号：US09637223B1

公开(公告)日：2017-05-02

申请号：US13457686

申请日：2012-04-27

申请人： Jack DiCocco ,  Troy Prince ,  Mehul Patel ,  Tsun Ming Terry Ng

发明人： Jack DiCocco ,  Troy Prince ,  Mehul Patel ,  Tsun Ming Terry Ng

IPC分类号： B64C21/00

CPC分类号： B64C21/00 ,  B64C5/12 ,  F41G7/00 ,  F42B10/14 ,  F42B10/60 ,  F42B10/62 ,  F42B15/01 ,  G05D1/0088

摘要： An afterbody flow control system is used for aircraft or missile flow control to provide enhanced maneuverability and stabilization. A method of operating the flow control system is also described. The missile or aircraft comprises an afterbody and a forebody; at least one activatable flow effector on the missile or aircraft afterbody; at least one sensor having a signal, the at least one sensor being positioned to detect forces or flow conditions on the missile or aircraft afterbody; and a closed loop control system; wherein the closed loop control system is used for activating and deactivating the at least one activatable flow effector based on at least in part the signal of the at least one sensor.

公开(公告)号：US09023647B2

公开(公告)日：2015-05-05

申请号：US13293868

申请日：2011-11-10

申请人： Stephen Poole ,  Mehul Patel

发明人： Stephen Poole ,  Mehul Patel

IPC分类号： C12N5/00 ,  G01N33/68 ,  G01N33/50

CPC分类号： G01N33/6869 ,  G01N33/5047 ,  G01N33/5055 ,  G01N33/5091 ,  G01N33/6863 ,  G01N2333/5412 ,  G01N2800/7095

摘要： An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests that include at least one microtiter well having at least one interior surface comprising polypropylene and having a shape such that monocyte-containing reagent is concentrated in the well to provide greater cell to cell contact. The invention also relates to a diagnostic kit that can be used to test for the presence of non-endotoxin pyrogens in a sample.

摘要翻译： 描述了改进的单核细胞活化试验，其更能够检测医疗产品中的非内毒素热原，其中将样品与包含至少一个包含聚丙烯的表面的测定系统中的含单核细胞的试剂一起温育。 本发明还涉及用于这些测试的测定系统，其包括至少一个微量滴定孔，其具有至少一个包含聚丙烯的内表面，并且具有使含单核细胞的试剂在孔中浓缩以提供更大的细胞与细胞接触的形状。 本发明还涉及可用于测试样品中非内毒素热原的存在的诊断试剂盒。

公开(公告)号：US20140100231A1

公开(公告)日：2014-04-10

申请号：US14047515

申请日：2013-10-07

申请人： Kenneth L. Arrington ,  Christopher Burgey ,  Robert Gilfillan ,  Yongxin Han ,  Mehul Patel ,  Chun Sing Li ,  Yaozong Li ,  Yunfu Luo ,  Zhiyu Lei

发明人： Kenneth L. Arrington ,  Christopher Burgey ,  Robert Gilfillan ,  Yongxin Han ,  Mehul Patel ,  Chun Sing Li ,  Yaozong Li ,  Yunfu Luo ,  Zhiyu Lei

IPC分类号： A61K31/513 ,  C07D405/14 ,  C07D403/06 ,  C07D471/04 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K31/513 ,  A61K45/06 ,  C07D239/52 ,  C07D239/54 ,  C07D239/56 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14

摘要： Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

摘要翻译： 式I化合物是HIV逆转录酶抑制剂，其中R1，R2，RE，L，M和Z在本文中定义。 式I化合物及其药学上可接受的盐可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发作或进展以及AIDS治疗。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

公开(公告)号：US08548650B1

公开(公告)日：2013-10-01

申请号：US13455182

申请日：2012-04-25

申请人： Troy S. Prince ,  Richard Kolacinski ,  Mehul Patel

发明人： Troy S. Prince ,  Richard Kolacinski ,  Mehul Patel

IPC分类号： B64C13/00 ,  F41G7/00 ,  G01C23/00

CPC分类号： G05D1/107 ,  F42B10/38 ,  F42B10/40 ,  F42B10/42 ,  F42B10/668 ,  F42B15/01

摘要： The present invention relates to a missile or munition with a hierarchical, modular, closed-loop flow control system, more particularly to aircraft or munition with flow control system for enhanced aerodynamic control, maneuverability and stabilization. The present invention further relates to a method of operating the flow control system.Various embodiments of the flow control system involve elements including flow sensors, active flow control devices or activatable flow effectors, and logic devices with closed loop control architecture. The sensors are used to estimate or determine flow conditions on the surfaces of a missile or munition. The active flow control device or activatable flow effectors create on-demand flow disturbances, preferably micro-disturbances, at different points along the various aerodynamic surfaces of the missile or aircraft to achieve a desired stabilization or maneuverability effect. The logic devices are embedded with a hierarchical control structure allowing for rapid, real-time control at the flow surface.

摘要翻译： 本发明涉及具有分级，模块化，闭环流量控制系统的导弹或弹药，更具体地涉及具有用于增强的空气动力学控制，机动性和稳定性的流量控制系统的飞机或弹药。 本发明还涉及一种操作流量控制系统的方法。 流量控制系统的各种实施例涉及包括流量传感器，主动流量控制装置或可激活流动效应器以及具有闭环控制架构的逻辑装置的元件。 传感器用于估计或确定导弹或弹药表面的流动状况。 主动流量控制装置或可激活流动效应器沿着导弹或飞行器的各种空气动力学表面在不同点处产生按需的流动干扰，优选微扰动，以实现期望的稳定性或机动性效果。 逻辑器件嵌入了分层控制结构，允许在流表面进行快速，实时的控制。

公开(公告)号：US08367992B1

公开(公告)日：2013-02-05

申请号：US12977519

申请日：2010-12-23

申请人： Mehul Patel ,  T Terry Ng ,  Alan B Cain ,  Zak Sowle ,  Jack DiCocco

发明人： Mehul Patel ,  T Terry Ng ,  Alan B Cain ,  Zak Sowle ,  Jack DiCocco

IPC分类号： F42B10/02 ,  B64C3/54

CPC分类号： F42B10/64 ,  F41G7/20 ,  F42B3/006 ,  F42B10/02 ,  F42B15/00 ,  F42B15/01 ,  F42B15/36 ,  F42B19/01

摘要： The present invention relates to an aircraft, missile, projectile, or underwater vehicle with an improved control system and a method for increasing the maneuverability or stability of an aircraft, missile, projectile, or underwater vehicle. More particularly, the present invention relates to a method for increasing the maneuverability or stability of an aircraft, missile, underwater vehicle or projectile through the use of removable control surfaces. The technical advantage of the removable control surface system (or “removable control surface”) over other systems is that the removable control surface system enables the aircraft, missile, underwater vehicle or projectile to have two or more design configurations, each configuration being tailored to the aircraft, missile, projectile, or underwater vehicle's specific stability or maneuverability requirements during a specific portion of the flight.

摘要翻译： 本发明涉及一种具有改进的控制系统的飞机，导弹，射弹或水下车辆，以及用于增加飞机，导弹，射弹或水下航行器的机动性或稳定性的方法。 更具体地说，本发明涉及通过使用可拆卸的控制表面来提高飞机，导弹，水下航行器或射弹的机动性或稳定性的方法。 可移动控制表面系统（或可移除控制面）在其他系统上的技术优点在于，可移动控制面系统使得飞机，导弹，水下航行器或射弹能够具有两个或多个设计配置，每个配置适合飞机 ，导弹，射弹或水下航行器在特定部分飞行过程中的具体稳定性或机动性要求。

公开(公告)号：US08191833B1

公开(公告)日：2012-06-05

申请号：US11415534

申请日：2006-05-02

申请人： Jack DiCocco ,  Troy Prince ,  Mehul Patel ,  Tsun Ming Terry Ng

发明人： Jack DiCocco ,  Troy Prince ,  Mehul Patel ,  Tsun Ming Terry Ng

IPC分类号： B64C21/00

CPC分类号： B64C21/00 ,  B64C5/12 ,  F41G7/00 ,  F42B10/14 ,  F42B10/60 ,  F42B10/62 ,  F42B15/01 ,  G05D1/0088

摘要： The present invention relates to an afterbody flow control system and more particularly to aircraft or missile flow control system for enhanced maneuverability and stabilization. The present invention further relates to a method of operating the flow control system.In one embodiment, the present invention includes a missile or aircraft comprising an afterbody and a forebody; at least one activatable flow effector on the missile or aircraft afterbody; at least one sensor each having a signal, the at least one sensor being positioned to detect forces or flow conditions on the missile or aircraft afterbody; and a closed loop control system; wherein the closed loop control system is used for activating and deactivating the at least one activatable flow effector based on at least in part the signal of the at least one sensor.

摘要翻译： 本发明涉及后体流量控制系统，更具体地涉及用于增强机动性和稳定性的飞机或导弹流量控制系统。 本发明还涉及一种操作流量控制系统的方法。 在一个实施例中，本发明包括一个包括后身体和前体的导弹或飞机; 在导弹或飞机后身上至少有一个可激活的流动执行器; 每个具有信号的至少一个传感器，所述至少一个传感器被定位成检测导弹或飞机后身上的力或流动状况; 和闭环控制系统; 其中所述闭环控制系统用于至少部分地基于所述至少一个传感器的信号来激活和去激活所述至少一个可激活的流动效应器。

公开(公告)号：US08021130B2

公开(公告)日：2011-09-20

申请号：US11719518

申请日：2006-08-10

申请人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

发明人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

IPC分类号： F04B17/00

CPC分类号： F04B19/006 ,  B01J2219/0081 ,  B01J2219/00891 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/565 ,  B01L7/52 ,  B01L2300/0896 ,  B01L2400/0478 ,  B82Y30/00 ,  F04B9/02 ,  F04B23/06 ,  G01N2035/00158

摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.

摘要翻译： 以纳米级速率处理流体的装置和方法。 线性位移泵产生低至nl / mm范围的非脉动液体流速。 泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。 微流体互连装置可以联接到枪管。 这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置 在与泵的桶或桶相对的一侧与导热体接触。

公开(公告)号：US07940899B2

公开(公告)日：2011-05-10

申请号：US11545021

申请日：2006-10-06

申请人： John C. Moorman, III ,  Dhruv Chawla ,  Brian M. Castelli ,  Amy T. Leigh ,  Subramanian Sivaramakrishnan ,  Vorapong Sutanont ,  Sanjay Subramanian ,  Bennett R. Davis ,  Olufemi Tairu ,  Mehul Patel ,  John W. Dennis

发明人： John C. Moorman, III ,  Dhruv Chawla ,  Brian M. Castelli ,  Amy T. Leigh ,  Subramanian Sivaramakrishnan ,  Vorapong Sutanont ,  Sanjay Subramanian ,  Bennett R. Davis ,  Olufemi Tairu ,  Mehul Patel ,  John W. Dennis

IPC分类号： H04M1/64 ,  G06Q40/00

CPC分类号： G06Q40/00 ,  G06Q20/10 ,  G06Q40/025

摘要： Techniques using data matching and clustering algorithms are disclosed to aid investigators in detecting potentially fraudulent activity, performing risk analysis or assessing compliance with applicable regulations.

摘要翻译： 公开了使用数据匹配和聚类算法的技术，以帮助调查人员检测潜在的欺诈活动，执行风险分析或评估遵守适用法规。

公开(公告)号：US07880125B1

公开(公告)日：2011-02-01

申请号：US12077447

申请日：2008-03-19

申请人： Mehul Patel ,  T. Terry Ng ,  Alan B. Cain ,  Zak Sowle ,  Jack DiCocco

发明人： Mehul Patel ,  T. Terry Ng ,  Alan B. Cain ,  Zak Sowle ,  Jack DiCocco

IPC分类号： F42B15/01

CPC分类号： F42B10/64 ,  F41G7/20 ,  F42B3/006 ,  F42B10/02 ,  F42B15/00 ,  F42B15/01 ,  F42B15/36 ,  F42B19/01

摘要： The present invention relates to an aircraft, missile, projectile, or underwater vehicle with an improved control system and an improved control system for maneuvering an aircraft, missile, projectile, or underwater vehicle. More particularly, the present invention relates to an aircraft, missile, underwater vehicle or projectile with removable control surfaces. The technical advantage of the removable control surface system (or “removable control surface”) over other systems is that the removable control surface system enables the aircraft, missile, underwater vehicle or projectile to have two or more design configurations, each configuration being tailored to the aircraft, missile, projectile, or underwater vehicle's specific stability or maneuverability requirements during a specific portion of the flight.

摘要翻译： 本发明涉及具有改进的控制系统的飞机，导弹，射弹或水下航行器，以及用于操纵飞机，导弹，射弹或水下航行器的改进的控制系统。 更具体地，本发明涉及具有可移除控制表面的飞机，导弹，水下航行器或射弹。 可移动控制表面系统（或“可移除控制表面”）在其他系统上的技术优点是可移动控制表面系统使得飞机，导弹，水下航行器或射弹能够具有两个或多个设计配置，每个配置被定制为 飞机，导弹，射弹或水下航行器在特定部分飞行过程中的具体稳定性或机动性要求。

公开(公告)号：US07709772B1

公开(公告)日：2010-05-04

申请号：US11292972

申请日：2005-12-02

申请人： Mehul Patel ,  T. Terry Ng ,  Alan B. Cain ,  Zak Sowle ,  Jack DiCocco

发明人： Mehul Patel ,  T. Terry Ng ,  Alan B. Cain ,  Zak Sowle ,  Jack DiCocco

IPC分类号： F42B15/01

CPC分类号： F42B10/64 ,  F41G7/20 ,  F42B3/006 ,  F42B10/02 ,  F42B15/00 ,  F42B15/01 ,  F42B15/36 ,  F42B19/01

摘要： The present invention relates to an aircraft, missile, projectile, or underwater vehicle with an improved control system and an improved control system for maneuvering an aircraft, missile, projectile, or underwater vehicle. More particularly, the present invention relates to an aircraft, missile, underwater vehicle or projectile with removable control surfaces. The technical advantage of the removable control surface system (or “removable control surface”) over other systems is that the removable control surface system enables the aircraft, missile, underwater vehicle or projectile to have two or more design configurations, each configuration being tailored to the aircraft, missile, projectile, or underwater vehicle's specific stability or maneuverability requirements during a specific portion of the flight.

摘要翻译： 本发明涉及具有改进的控制系统的飞机，导弹，射弹或水下航行器，以及用于操纵飞机，导弹，射弹或水下航行器的改进的控制系统。 更具体地，本发明涉及具有可移除控制表面的飞机，导弹，水下航行器或射弹。 可移动控制表面系统（或“可移除控制表面”）在其他系统上的技术优点是可移动控制表面系统使得飞机，导弹，水下航行器或射弹能够具有两个或多个设计配置，每个配置被定制为 飞机，导弹，射弹或水下航行器在特定部分飞行过程中的具体稳定性或机动性要求。