-
公开(公告)号：US11613547B2
公开(公告)日：2023-03-28
申请号：US16924037
申请日：2020-07-08
申请人： University of Health Sciences & Pharmacy in St. Louis , University of Southern California , The University of North Carolina at Chapel Hill , Memorial Sloan Kettering Cancer Center , University of Florida Research Foundation, Incorporated , Memorial Sloan Kettering Cancer Center
发明人： Susruta Majumdar , Vsevolod Katritch , Bryan Roth , Jay McLaughlin , Saheem Zaidi , Gavril W. Pasternak , Rajendra Uprety
IPC分类号： C07D489/00 , C07D221/28
摘要： In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
-
公开(公告)号：US20210061814A1
公开(公告)日：2021-03-04
申请号：US16924037
申请日：2020-07-08
申请人： St. Louis College of Pharmacy , University of Southern California , The University of North Carolina at Chapel Hill , Memorial Sloan Kettering Cancer Center , University of Florida Research Foundation, Incorporated , Memorial Sloan Kettering Cancer Center
发明人： Susruta MAJUMDAR , Vsevolod KATRITCH , Bryan ROTH , JAY MCLAUGHLIN , Saheem ZAIDI , Gavril W. PASTERNAK , Rajendra UPRETY
IPC分类号： C07D489/00 , C07D221/28
摘要： In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
-
公开(公告)号：US12122844B2
公开(公告)日：2024-10-22
申请号：US16927675
申请日：2020-07-13
CPC分类号： C07K16/3053 , A61K48/005 , C07K16/22 , C07K16/24 , C07K16/2863 , A61K2039/505 , A61K48/00 , C07K2317/21 , C07K2317/24 , C12N2750/14141 , C12N2799/025
摘要： The invention provides methods to inhibit or treat brain cancers by locally inhibiting expression or activity of growth factors or growth factor receptors.
-
公开(公告)号：US20240307441A1
公开(公告)日：2024-09-19
申请号：US18538640
申请日：2023-12-13
发明人： Renier J. Brentjens , Mauro P. Avanzi , Sarah Yoo
IPC分类号： A61K35/17 , A61K38/20 , A61P35/00 , C07K14/54 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： A61K35/17 , A61K38/20 , A61P35/00 , C07K14/54 , C07K14/7051 , C07K14/70521 , C07K16/2803 , C12N5/0636 , C07K2319/02 , C07K2319/03 , C12N2501/2318 , C12N2510/02
摘要： The present disclosure provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells comprising antigen recognizing receptors (e.g., chimeric antigen receptors (CARs) or T cell receptors (TCRs)), and expressing increased level of IL-18. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and resistant to immunosuppression and/or have enhanced immune-activating properties.
-
公开(公告)号：US12086985B2
公开(公告)日：2024-09-10
申请号：US17218087
申请日：2021-03-30
申请人： Ventana Medical Systems, Inc. , Johns Hopkins University , Memorial Sloan Kettering Cancer Center
发明人： Mehrnoush Khojasteh , Jim F. Martin , Lidija Pestic-Dragovich , Lei Tang , Xiangxue Wang , Wenjun Zhang , Robert Anders , Luis Diaz
IPC分类号： G16H50/50 , C07K16/28 , G06T7/00 , G16H10/40 , G16H20/10 , G16H30/20 , G16H30/40 , G16H50/20 , G16H50/70
CPC分类号： G06T7/0016 , C07K16/2818 , G16H10/40 , G16H20/10 , G16H30/20 , G16H30/40 , G16H50/20 , G16H50/50 , G16H50/70 , C07K2317/24 , G06T2207/10056 , G06T2207/30024 , G06T2207/30096
摘要： A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.
-
公开(公告)号：US20240293481A1
公开(公告)日：2024-09-05
申请号：US18656397
申请日：2024-05-06
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Melody Smith , Marcel Van Den Brink , Anqi Dai , Sean Devlin , Marco Ruella , Andrea Facciabene
IPC分类号： A61K35/742 , A61K35/17 , A61K35/745 , A61K35/747 , A61K39/00 , A61K45/06 , C12Q1/06 , C12Q1/689
CPC分类号： A61K35/742 , A61K35/17 , A61K35/745 , A61K35/747 , A61K39/4611 , A61K39/4631 , A61K39/464412 , A61K39/464417 , A61K45/06 , C12Q1/06 , C12Q1/689 , C12Q2600/106
摘要： The present disclosure relates to compositions and methods for predicting cancer survival or toxicity in a subject receiving a chimeric antigen receptor (CAR) T cell therapy. The present disclosure further discloses compositions, e.g., pharmaceutical compositions, and methods for treating said subject.
-
公开(公告)号：US12072481B2
公开(公告)日：2024-08-27
申请号：US17717774
申请日：2022-04-11
CPC分类号： G02B21/361 , A61B5/0068 , A61B5/0077 , A61B5/444 , G02B21/0008 , G02B21/0028 , G02B21/0036 , G02B21/02 , G02B21/06 , A61B5/0075
摘要： A device for viewing a target, the device including a housing, an objective lens positioned within the housing, where the objective lens has a first lens group including at least a first lens and a second lens group including at least a second lens, the first lens positioned closer to the target than the second lens, and a camera positioned within the objective lens between the first lens and the second lens, where the camera is configured to provide images of the target located near a focal point of the objective lens, and wherein the arrangement of the first lens, the second lens, and the camera provides for simultaneous capture of a first image of a surface of the target and a second image of a sub-surface cellular structure of the target.
-
公开(公告)号：US20240279601A1
公开(公告)日：2024-08-22
申请号：US18542134
申请日：2023-12-15
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
发明人： Lorenz STUDER , Yujie Fan
IPC分类号： C12N5/0793 , A61K35/30
CPC分类号： C12N5/0619 , A61K35/30 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/19 , C12N2501/415 , C12N2506/45
摘要： The present disclosure relates to methods for generating sacral neural crest lineage cells and enteric neurons. Also provided are sacral neural crest lineage cells and enteric neurons generated by the presently disclosed methods and compositions comprising such cells. The present disclosure further provides uses of the sacral neural crest lineage cells and enteric neurons for preventing, modeling, and/or treating of enteric nervous system disorders.
-
公开(公告)号：US20240279600A1
公开(公告)日：2024-08-22
申请号：US18647342
申请日：2024-04-26
IPC分类号： C12N5/079
CPC分类号： C12N5/0618 , C12N2501/999
摘要： The present disclosure provides compositions, kits, and methods for promoting in vitro maturation of cells. The present disclosure also provides methods of screening compounds that are suitable for promoting in vitro maturation of cells.
-
公开(公告)号：US20240261402A1
公开(公告)日：2024-08-08
申请号：US18560436
申请日：2022-05-13
IPC分类号： A61K39/00 , C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： A61K39/4611 , A61K39/4631 , A61K39/4632 , A61K39/464412 , C07K14/7051 , C07K16/2803 , C12N5/0636 , C07K2317/73 , C12N2510/00
摘要： The present invention provides NKG2C+CD8+ T cells, including engineered NKG2C+CD8+ T cells expressing chimeric antigen receptor (CAR) A molecules or transgenic T cell receptors, compositions comprising such cells, methods of generating such cells from conventional CD8+ T cells, and methods of using such cells, for example in adoptive cell therapy methods.
-
-
-
-
-
-
-
-
-
搜索结果
1283 条记录 (耗时 0.026 秒)
