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公开(公告)号：US07807109B2
公开(公告)日：2010-10-05
申请号：US11803349
申请日：2007-05-14
Applicant: Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
Inventor： Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
CPC classification number: C40B60/08 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00319 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00693 , B01J2219/00698 , B01J2219/0072 , B01J2219/00736 , B01J2219/00738 , B01J2219/00747
Abstract: Described is a parallel batch reactor for effecting chemical reactions. The parallel batch reactor includes a plurality of reactor vessels for receiving components of a reaction, an inlet port for receiving pressurized fluid, and a plurality of valves configured to transfer fluid from the inlet port to the reactor vessels and fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The reactor further includes a pressure monitoring system comprising an array of pressure sensors configured to sense pressure in the reactor vessels. Each of the pressure sensors is aligned with one of the plurality of reactor vessels and located external to the reactor vessels and fluid passageways in fluid communication with the reactor vessels.
Abstract translation: 描述了用于进行化学反应的平行间歇反应器。 并联反应器包括用于接收反应组分的多个反应器容器，用于接收加压流体的入口端口和多个阀，所述多个阀被配置成将流体从入口传送到反应器容器并且流体地隔离一个或多个 来自至少一个其他反应器容器的反应器容器。 反应器还包括压力监测系统，其包括被配置为感测反应器容器中的压力的压力传感器阵列。 每个压力传感器与多个反应器容器中的一个对准并且位于反应器容器外部和与反应器容器流体连通的流体通道。
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公开(公告)号：US06701774B2
公开(公告)日：2004-03-09
申请号：US09801430
申请日：2001-03-07
Applicant: Ravi Srinivasan , Daniel Meron Pinkas , Shenheng Guan , Michael Myslovaty , Michael Spitkovsky , James R. Engstrom , H. Sam Bergh
Inventor： Ravi Srinivasan , Daniel Meron Pinkas , Shenheng Guan , Michael Myslovaty , Michael Spitkovsky , James R. Engstrom , H. Sam Bergh
IPC: G01N3004
CPC classification number: G01N30/18 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , G01N30/466 , G01N30/6004 , G01N30/6095 , G01N30/66 , G01N30/8631 , G01N2030/185 , G01N2030/208 , G01N2030/3084 , G01N2030/8881
Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
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公开(公告)号：US20080286170A1
公开(公告)日：2008-11-20
申请号：US11803348
申请日：2007-05-14
Applicant: Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
Inventor： Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00698 , B01J2219/00702 , B01J2219/0072 , B01J2219/00736 , B01J2219/00747 , C40B60/08 , C40B60/14
Abstract: In one embodiment, a parallel batch reactor for effecting chemical reactions includes a vessel block comprising reactor vessels for receiving components of a reaction and a valve block removably attached to the vessel block. The valve block includes a first plurality of valves in fluid communication with an inlet port for supplying pressurized fluid to the reactor vessels and configured to fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The valve block further includes a second plurality of valves in fluid communication with the reactor vessels for injecting chemical components into the pressurized reactor vessels or sampling chemical components from the pressurized reactor vessels. The vessel block and valve block are configured to sustain an operating pressure of at least 15 psig.
Abstract translation: 在一个实施方案中，用于实现化学反应的并行批量反应器包括容器块，其包含用于接收反应组分的反应器容器和可移除地附接到容器块的阀块。 阀块包括与入口端口流体连通的第一多个阀，用于将加压流体供应到反应器容器并且构造成将一个或多个反应器容器与至少一个其它反应器容器进行流体隔离。 阀块还包括与反应器容器流体连通的第二多个阀，用于将化学组分注入加压反应器容器或从加压反应器容器取样化学组分。 容器块和阀块被配置为维持至少15psig的操作压力。
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公开(公告)号：US07281408B2
公开(公告)日：2007-10-16
申请号：US10718196
申请日：2003-11-20
Applicant: Ravi Srinivasan , Daniel M. Pinkas , Shenheng Guan , Michael Myslovaty , Mikhail Spitkovsy , James R. Engstrom , H. Sam Bergh
Inventor： Ravi Srinivasan , Daniel M. Pinkas , Shenheng Guan , Michael Myslovaty , Mikhail Spitkovsy , James R. Engstrom , H. Sam Bergh
IPC: G01N30/04
CPC classification number: G01N30/18 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , G01N30/466 , G01N30/6004 , G01N30/6095 , G01N30/66 , G01N30/8631 , G01N2030/185 , G01N2030/208 , G01N2030/3084 , G01N2030/8881
Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
Abstract translation: 本发明的气相色谱通常包含四个或更多个分析通道。 具体地说，四个或更多个气相色谱柱被配置用于并行分析四种或更多种气态样品，其中使用包含四个或更多微量检测器的微量检测器阵列进行检测。 在一个实施例中，四个或更多个微检测器510是微制造的检测器，并且与基板或与安装在基板上的一个或多个微芯片体整体形成。 在优选实施例中，微检测器阵列包括具有一个或多个薄膜检测丝的四个或更多个热导检测器。 还公开了用于高度平行的气相色谱仪的优选的加热环境。
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Patent Agency Ranking
公开(公告)号：US5657617A
公开(公告)日：1997-08-19
申请号：US591853
申请日：1996-01-25
Applicant: Ronald Allen , Michael Myslovaty , Michael Edwin Slafter
Inventor： Ronald Allen , Michael Myslovaty , Michael Edwin Slafter
CPC classification number: B65B69/00 , B65B7/2842
Abstract: Apparatus for placing covers (5, 8) on a cassette (1) and taking covers (5, 8) off a cassette (1) comprises an upper cover removal structure (100U), a lower cover removal structure (100L), and means for holding the cassette in place (170-176). The upper cover removal structure (100U) includes a central body portion (102), a pair of arms (104, 106) rotatably mounted at the end of the central body portion, and fingers (112, 114) located at the end of the arms (104, 106). The fingers (112, 114) can be moved up and down in a direction parallel to the main axis of the arms. The upper cover removal structure (100U) includes means for moving the upper cover removal structure (100U) toward or away from the cassette (1). The lower cover removal structure (100L) includes a central body portion and a pair of arms 156, 158 having fingers (190, 192) at the ends thereof. The arms can move inwardly or outwardly to grasp the bottom cover (8). Also included are means (154) for moving the lower cover removal unit (100L) toward or away from the cassette. The apparatus is designed to minimize generation of particulate contamination. For example, during use, arms (104, 106) and fingers (112, 114) pull tongues (20) of top cover (5) outwardly so that catches (23) on tongues (20) do not snap over rims on the cassettes and generate particulate contamination.
Abstract translation: 用于将盖（5,8）放置在盒（1）上并从盒（1）上取下盖（5,8）的装置包括上盖移除结构（100U），下盖移除结构（100L）和装置 用于将盒子保持在位（170-176）。 上盖拆卸结构（100U）包括中心主体部分（102），可旋转地安装在中心主体部分的端部处的一对臂（104,106），以及位于中心主体部分的端部处的手指（112,114） 臂（104,106）。 手指（112,114）可以在平行于臂的主轴线的方向上上下移动。 上盖移除结构（100U）包括用于将上盖移除结构（100U）朝向或远离盒（1）移动的装置。 下盖移除结构（100L）包括中心主体部分和在其端部具有指状物（190,192）的一对臂156,158。 臂可以向内或向外移动以抓住底盖（8）。 还包括用于将下盖拆卸单元（100L）朝向或远离盒移动的装置（154）。 该设备被设计为最小化颗粒污染物的产生。 例如，在使用期间，臂（104,106）和手指（112,114）向外拉动顶盖（5）的舌部（20），使得舌片（20）上的卡扣（23）不卡在盒子上的边缘上 并产生颗粒污染。
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公开(公告)号：US07655191B2
公开(公告)日：2010-02-02
申请号：US11803224
申请日：2007-05-14
Applicant: Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
Inventor： Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
CPC classification number: B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00319 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00601 , B01J2219/00693 , B01J2219/00698 , B01J2219/00702 , B01J2219/0072 , B01J2219/00736 , B01J2219/00738 , B01J2219/00747 , C40B60/08 , Y10T436/25
Abstract: In one embodiment, a parallel batch reactor generally includes a plurality of reactor vessels and a plurality of valves configured to allow flow into the reactor vessels when a gas is supplied to the reactor at a pressure higher than a pressure within the reactor vessels and restrict flow from the reactor vessels. A method includes inserting chemical components into the reactor vessels, supplying a first gas to the reactor vessels to pressurize the reactor vessels, stopping supply of the first gas, and supplying a second gas to the reactor at a lower pressure than a pressure within the reactor vessels. The second gas passes through the valves and into the reactor vessels when the pressure within the reactor vessels drops below the pressure of the second gas.
Abstract translation: 在一个实施方案中，平行间歇反应器通常包括多个反应器容器和多个阀，其构造成当气体以高于反应器容器内的压力的压力供应到反应器中时允许流入反应器容器，并限制流动 从反应堆船只。 一种方法包括将化学成分插入反应器容器中，向反应器容器中提供第一气体以加压反应器容器，停止供应第一气体，并以比反应器内的压力更低的压力向反应器供应第二气体 船只。 当反应器容器内的压力低于第二气体的压力时，第二气体通过阀门进入反应器容器。
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公开(公告)号：US20090004063A1
公开(公告)日：2009-01-01
申请号：US11771824
申请日：2007-06-29
Applicant: Kenneth Higashihara , Jeffrey Yoder , Tuyen Nguyen , Scott Whiting , Michael Myslovaty
Inventor： Kenneth Higashihara , Jeffrey Yoder , Tuyen Nguyen , Scott Whiting , Michael Myslovaty
CPC classification number: G01N35/0099 , A61M5/008 , G01N35/1009 , G01N2035/0434
Abstract: A robotic workstation includes apparatus for actuating one or more syringes. Each syringe has a cylinder and a plunger movable in the cylinder. A programmable robot has at least one syringe actuating device. The actuating device has a holder for holding and releasing a syringe cylinder and an actuator movable relative to the holder. A coupling couples the actuator to the plunger of the syringe such that, when the cylinder is held by the holder, movement of the actuator relative to the holder causes the plunger to move in the cylinder. A method of dispensing a material into a container includes robotically moving at least one syringe to a position for dispensing into a container. The plunger is robotically moved in the cylinder to dispense material from the syringe into the container. The workstation suitably includes a mixing apparatus for mixing materials in an array of containers at the workstation.
Abstract translation: 机器人工作站包括用于致动一个或多个注射器的装置。 每个注射器具有可在气缸中移动的气缸和柱塞。 可编程机器人具有至少一个注射器致动装置。 致动装置具有用于保持和释放注射器筒的保持器和可相对于保持器移动的致动器。 联接器将致动器连接到注射器的柱塞，使得当气缸由保持器保持时，致动器相对于保持器的运动导致柱塞在气缸中移动。 将材料分配到容器中的方法包括将至少一个注射器机械地移动到用于分配到容器中的位置。 柱塞在气缸中自动移动以将材料从注射器分配到容器中。 工作站适当地包括用于在工作站处将容器的阵列中的材料混合的混合装置。
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公开(公告)号：US20080286174A1
公开(公告)日：2008-11-20
申请号：US11803224
申请日：2007-05-14
Applicant: Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
Inventor： Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
CPC classification number: B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00319 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00601 , B01J2219/00693 , B01J2219/00698 , B01J2219/00702 , B01J2219/0072 , B01J2219/00736 , B01J2219/00738 , B01J2219/00747 , C40B60/08 , Y10T436/25
Abstract: In one embodiment, a parallel batch reactor generally includes a plurality of reactor vessels and a plurality of valves configured to allow flow into the reactor vessels when a gas is supplied to the reactor at a pressure higher than a pressure within the reactor vessels and restrict flow from the reactor vessels. A method includes inserting chemical components into the reactor vessels, supplying a first gas to the reactor vessels to pressurize the reactor vessels, stopping supply of the first gas, and supplying a second gas to the reactor at a lower pressure than a pressure within the reactor vessels. The second gas passes through the valves and into the reactor vessels when the pressure within the reactor vessels drops below the pressure of the second gas.
Abstract translation: 在一个实施方案中，平行间歇反应器通常包括多个反应器容器和多个阀，其构造成当气体以高于反应器容器内的压力的压力供应到反应器中时允许流入反应器容器，并限制流动 从反应堆船只。 一种方法包括将化学成分插入反应器容器中，向反应器容器中提供第一气体以加压反应器容器，停止供应第一气体，并以比反应器内的压力更低的压力向反应器供应第二气体 船只。 当反应器容器内的压力低于第二气体的压力时，第二气体通过阀门进入反应器容器。
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公开(公告)号：US20080286171A1
公开(公告)日：2008-11-20
申请号：US11803349
申请日：2007-05-14
Applicant: Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
Inventor： Gary M. Diamond , Keith A. Hall , Thomas Harding McWaid , Vince Murphy , Michael Myslovaty , James A. W. Shoemaker , Robbie Singh Sidhu , Howard Turner , Eric Dias , Mikhail Spitkovsky
IPC: B01J19/00
CPC classification number: C40B60/08 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00319 , B01J2219/00337 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00693 , B01J2219/00698 , B01J2219/0072 , B01J2219/00736 , B01J2219/00738 , B01J2219/00747
Abstract: In one embodiment, a parallel batch reactor for effecting chemical reactions includes a plurality of reactor vessels for receiving components of a reaction, an inlet port for receiving pressurized fluid, and a plurality of valves configured to transfer fluid from the inlet port to the reactor vessels and fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The reactor further includes a pressure monitoring system comprising an array of pressure sensors configured to sense pressure in the reactor vessels. Each of the pressure sensors is aligned with one of the plurality of reactor vessels and located external to the reactor vessels and fluid passageways in fluid communication with the reactor vessels.
Abstract translation: 在一个实施方案中，用于实现化学反应的并联批量反应器包括用于接收反应组分的多个反应器容器，用于接收加压流体的入口端口和多个阀，其配置成将流体从入口传送到反应器容器 并且将一个或多个反应器容器与至少一个其它反应器容器流体隔离。 反应器还包括压力监测系统，其包括被配置为感测反应器容器中的压力的压力传感器阵列。 每个压力传感器与多个反应器容器中的一个对准并且位于反应器容器外部和与反应器容器流体连通的流体通道。
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