公开(公告)号：US07807109B2

公开(公告)日：2010-10-05

申请号：US11803349

申请日：2007-05-14

申请人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

发明人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC分类号： G05D16/00 ,  B01J19/00

CPC分类号： C40B60/08 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747

摘要： Described is a parallel batch reactor for effecting chemical reactions. The parallel batch reactor includes a plurality of reactor vessels for receiving components of a reaction, an inlet port for receiving pressurized fluid, and a plurality of valves configured to transfer fluid from the inlet port to the reactor vessels and fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The reactor further includes a pressure monitoring system comprising an array of pressure sensors configured to sense pressure in the reactor vessels. Each of the pressure sensors is aligned with one of the plurality of reactor vessels and located external to the reactor vessels and fluid passageways in fluid communication with the reactor vessels.

摘要翻译： 描述了用于进行化学反应的平行间歇反应器。 并联反应器包括用于接收反应组分的多个反应器容器，用于接收加压流体的入口端口和多个阀，所述多个阀被配置成将流体从入口传送到反应器容器并且流体地隔离一个或多个 来自至少一个其他反应器容器的反应器容器。 反应器还包括压力监测系统，其包括被配置为感测反应器容器中的压力的​​压力传感器阵列。 每个压力传感器与多个反应器容器中的一个对准并且位于反应器容器外部和与反应器容器流体连通的流体通道。

公开(公告)号：US07507337B2

公开(公告)日：2009-03-24

申请号：US11219073

申请日：2005-09-02

申请人： Miroslav Petro ,  Gary M. Diamond ,  Thomas Harding McWaid ,  Keith Anthony Hall ,  Li Song ,  Trevor G. Frank

发明人： Miroslav Petro ,  Gary M. Diamond ,  Thomas Harding McWaid ,  Keith Anthony Hall ,  Li Song ,  Trevor G. Frank

IPC分类号： B01D15/08

CPC分类号： G01N30/30 ,  B01D15/161 ,  B01D15/166 ,  G01N30/20 ,  G01N30/28 ,  G01N30/32 ,  G01N30/34 ,  G01N30/80

摘要： The invention relates to liquid chromatography techniques for rapidly characterizing samples, such as polymer solutions, emulsions and dispersions, and to devices for implementing such techniques. The system includes a design that provides the ability to perform chromatographic separations by using mobile phase composition gradients and temperature gradients during separations. The invention accomplishes this by providing mixing zones for a plurality of fluids as well as heated and chilled feeds feeding the fluids to the mixing zones. Additionally, the system provides the ability to analyze separated components with a detector and/or collect separated fractions into vessels of a fraction collector for further separation and/or analysis.

摘要翻译： 本发明涉及用于快速表征样品的液相色谱技术，例如聚合物溶液，乳液和分散体，以及用于实施这些技术的装置。 该系统包括通过在分离期间使用流动相组成梯度和温度梯度提供进行色谱分离的能力的设计。 本发明通过为多种流体提供混合区域以及将流体供给到混合区域的加热和冷冻进料来实现。 此外，该系统提供了利用检测器分析分离的组分和/或将分离的馏分收集到馏分收集器的容器中用于进一步分离和/或分析的能力。

公开(公告)号：US20080286170A1

公开(公告)日：2008-11-20

申请号：US11803348

申请日：2007-05-14

申请人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

发明人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00747 ,  C40B60/08 ,  C40B60/14

摘要： In one embodiment, a parallel batch reactor for effecting chemical reactions includes a vessel block comprising reactor vessels for receiving components of a reaction and a valve block removably attached to the vessel block. The valve block includes a first plurality of valves in fluid communication with an inlet port for supplying pressurized fluid to the reactor vessels and configured to fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The valve block further includes a second plurality of valves in fluid communication with the reactor vessels for injecting chemical components into the pressurized reactor vessels or sampling chemical components from the pressurized reactor vessels. The vessel block and valve block are configured to sustain an operating pressure of at least 15 psig.

摘要翻译： 在一个实施方案中，用于实现化学反应的并行批量反应器包括容器块，其包含用于接收反应组分的反应器容器和可移除地附接到容器块的阀块。 阀块包括与入口端口流体连通的第一多个阀，用于将加压流体供应到反应器容器并且构造成将一个或多个反应器容器与至少一个其它反应器容器进行流体隔离。 阀块还包括与反应器容器流体连通的第二多个阀，用于将化学组分注入加压反应器容器或从加压反应器容器取样化学组分。 容器块和阀块被配置为维持至少15psig的操作压力。

公开(公告)号：US20100081577A1

公开(公告)日：2010-04-01

申请号：US12242893

申请日：2008-09-30

申请人： Robbie Singh Sidhu ,  Thomas Harding McWaid ,  Gary M. Diamond ,  Keith Anthony Hall ,  Susan J. Schofer ,  Eric L. Dias ,  Thomas R. Boussie ,  Victor O. Nava-Salgado

发明人： Robbie Singh Sidhu ,  Thomas Harding McWaid ,  Gary M. Diamond ,  Keith Anthony Hall ,  Susan J. Schofer ,  Eric L. Dias ,  Thomas R. Boussie ,  Victor O. Nava-Salgado

IPC分类号： C40B30/00 ,  C40B60/08

CPC分类号： B01J19/0046 ,  B01J2219/00308 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601

摘要： A reactor system includes a housing and a plurality of reactors at least partially contained in the housing. The reactors each have a containment structure enclosing an internal space in the reactor. The containment structure including a circumferential sidewall having opposite ends and surrounding at least a portion of said internal space. The sidewall has a thermal mass and a sidewall heater adjacent an exterior surface of the sidewall. The ratio of the thermal mass of the sidewall to a volume of the portion of the internal space that is surrounded by the sidewall is relatively low.

摘要翻译： 反应器系统包括壳体和至少部分地容纳在壳体中的多个反应器。 反应器各自具有在反应器中包围内部空间的容纳结构。 所述容纳结构包括具有相对端并围绕所述内部空间的至少一部分的周向侧壁。 侧壁具有邻近侧壁的外表面的热质量和侧壁加热器。 侧壁的热质量与由侧壁包围的内部空间的部分的体积的比率相对较低。

公开(公告)号：US07655191B2

公开(公告)日：2010-02-02

申请号：US11803224

申请日：2007-05-14

申请人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

发明人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC分类号： B01J19/00 ,  B01J3/00 ,  G01N1/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747 ,  C40B60/08 ,  Y10T436/25

摘要： In one embodiment, a parallel batch reactor generally includes a plurality of reactor vessels and a plurality of valves configured to allow flow into the reactor vessels when a gas is supplied to the reactor at a pressure higher than a pressure within the reactor vessels and restrict flow from the reactor vessels. A method includes inserting chemical components into the reactor vessels, supplying a first gas to the reactor vessels to pressurize the reactor vessels, stopping supply of the first gas, and supplying a second gas to the reactor at a lower pressure than a pressure within the reactor vessels. The second gas passes through the valves and into the reactor vessels when the pressure within the reactor vessels drops below the pressure of the second gas.

摘要翻译： 在一个实施方案中，平行间歇反应器通常包括多个反应器容器和多个阀，其构造成当气体以高于反应器容器内的压力的压力供应到反应器中时允许流入反应器容器，并限制流动 从反应堆船只。 一种方法包括将化学成分插入反应器容器中，向反应器容器中提供第一气体以加压反应器容器，停止供应第一气体，并以比反应器内的压力更低的压力向反应器供应第二气体 船只。 当反应器容器内的压力低于第二气体的压力时，第二气体通过阀门进入反应器容器。

公开(公告)号：US20080286174A1

公开(公告)日：2008-11-20

申请号：US11803224

申请日：2007-05-14

申请人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

发明人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC分类号： B01J8/00 ,  B01J12/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747 ,  C40B60/08 ,  Y10T436/25

摘要： In one embodiment, a parallel batch reactor generally includes a plurality of reactor vessels and a plurality of valves configured to allow flow into the reactor vessels when a gas is supplied to the reactor at a pressure higher than a pressure within the reactor vessels and restrict flow from the reactor vessels. A method includes inserting chemical components into the reactor vessels, supplying a first gas to the reactor vessels to pressurize the reactor vessels, stopping supply of the first gas, and supplying a second gas to the reactor at a lower pressure than a pressure within the reactor vessels. The second gas passes through the valves and into the reactor vessels when the pressure within the reactor vessels drops below the pressure of the second gas.

摘要翻译： 在一个实施方案中，平行间歇反应器通常包括多个反应器容器和多个阀，其构造成当气体以高于反应器容器内的压力的压力供应到反应器中时允许流入反应器容器，并限制流动 从反应堆船只。 一种方法包括将化学成分插入反应器容器中，向反应器容器中提供第一气体以加压反应器容器，停止供应第一气体，并以比反应器内的压力更低的压力向反应器供应第二气体 船只。 当反应器容器内的压力低于第二气体的压力时，第二气体通过阀门进入反应器容器。

公开(公告)号：US20080286171A1

公开(公告)日：2008-11-20

申请号：US11803349

申请日：2007-05-14

申请人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

发明人： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC分类号： B01J19/00

CPC分类号： C40B60/08 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747

摘要： In one embodiment, a parallel batch reactor for effecting chemical reactions includes a plurality of reactor vessels for receiving components of a reaction, an inlet port for receiving pressurized fluid, and a plurality of valves configured to transfer fluid from the inlet port to the reactor vessels and fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The reactor further includes a pressure monitoring system comprising an array of pressure sensors configured to sense pressure in the reactor vessels. Each of the pressure sensors is aligned with one of the plurality of reactor vessels and located external to the reactor vessels and fluid passageways in fluid communication with the reactor vessels.

摘要翻译： 在一个实施方案中，用于实现化学反应的并联批量反应器包括用于接收反应组分的多个反应器容器，用于接收加压流体的入口端口和多个阀，其配置成将流体从入口传送到反应器容器 并且将一个或多个反应器容器与至少一个其它反应器容器流体隔离。 反应器还包括压力监测系统，其包括被配置为感测反应器容器中的压力的​​压力传感器阵列。 每个压力传感器与多个反应器容器中的一个对准并且位于反应器容器外部和与反应器容器流体连通的流体通道。