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    Flow cell array and the utilization thereof for multianalyte determination
    1.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 有权
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US08053225B2

    公开(公告)日：2011-11-08

    申请号：US12695553

    申请日：2010-01-28

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Kit and method for determining a plurality of analytes
    4.
    发明授权
    Kit and method for determining a plurality of analytes 有权
    用于确定多种分析物的试剂盒和方法

    公开(公告)号：US07396675B2

    公开(公告)日：2008-07-08

    申请号：US10296851

    申请日：2001-05-25

    申请人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    IPC分类号： G01N33/543 ,  G01N33/551

    CPC分类号： G01N21/6452 ,  B01L3/5085 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10S435/808 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808

    摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.

    摘要翻译： 本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导 至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个 由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触 所述测量区域在所述传感器平台上直接或与其它试剂混合之后。 本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

    Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
    5.
    发明授权
    Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence 有权
    用于使用ev逝激发光的并行检测多个分析物的传感器平台和方法

    公开(公告)号：US06289144B1

    公开(公告)日：2001-09-11

    申请号：US09487560

    申请日：2000-01-19

    申请人： Dieter Neuschäfer ,  Gert Ludwig Duveneck ,  Michael Pawlak ,  Uwe Pieles ,  Wolfgang Budach

    发明人： Dieter Neuschäfer ,  Gert Ludwig Duveneck ,  Michael Pawlak ,  Uwe Pieles ,  Wolfgang Budach

    IPC分类号： G02B600

    CPC分类号： G01N21/648 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/7703 ,  G01N2021/0346 ,  G01N2021/7786 ,  G01N2021/7793

    摘要： The invention relates to a sensor platform based on at least two planar, separate, inorganic dielectric waveguiding regions on a common substrate and to a method for the parallel evanescent excitation and detection of the luminescence of identical or different analytes. The invention relates also to a modified sensor platform that consists of the sensor platform having the planar, separate, inorganic dielectric waveguiding regions and one or more organic phases immobilised thereon. A further subject of the invention is the use of the sensor platform or of the modified sensor platform in a luminescence detection method for quantitative affinity sensing and for the selective quantitative determination of luminescent constituents of optically opaque solutions.

    摘要翻译： 本发明涉及一种基于公共衬底上的至少两个平面，分离的无机介电波导区域的传感器平台，以及用于平行ev逝激发和检测相同或不同分析物的发光的方法。 本发明还涉及一种由传感器平台组成的改进的传感器平台，传感器平台具有平面，分离的无机介质波导区域和固定在其上的一个或多个有机相。 本发明的另一个主题是在用于定量亲和力感测的发光检测方法中以及用于选择性定量确定光学不透明溶液的发光成分的传感器平台或修改的传感器平台的使用。

    Integrated optical luminescence sensor
    6.
    发明授权
    Integrated optical luminescence sensor 有权
    集成光学发光传感器

    公开(公告)号：US06211954B1

    公开(公告)日：2001-04-03

    申请号：US09155617

    申请日：1999-11-05

    申请人： Burkhard Danielzik ,  Dieter Neuschäfer ,  Michael Pawlak ,  Gert Ludwig Duveneck

    发明人： Burkhard Danielzik ,  Dieter Neuschäfer ,  Michael Pawlak ,  Gert Ludwig Duveneck

    IPC分类号： G01N2164

    CPC分类号： G01N21/648 ,  G01N21/7703

    摘要： An integrated-optical luminescence sensor having an excitation light beam with a first optical axis (kein), a planar waveguide (1), a sample interacting with the evanescent field thereof, and a detection beam path, with a second optical axis, that comes from the waveguide, and/or a coupling-out grating (7) for coupling out the portion of luminescence light guided in the waveguide, wherein the luminescence light to be detected is physically separate from the excitation light.

    摘要翻译： 一种集成光学发光传感器，其具有具有第一光轴（kein）的激发光束，平面波导（1），与其消逝场相互作用的样本以及具有第二光轴的检测光束路径，其具有来自 和/或用于耦合在波导管中引导的发光的部分的耦合出光栅（7），其中待检测的发光与物理上与激发光分离。

    Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence
    7.
    发明授权
    Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence 失效
    用于使用ev逝激发光的并行检测多个分析物的传感器平台和方法

    公开(公告)号：US6078705A

    公开(公告)日：2000-06-20

    申请号：US945588

    申请日：1997-10-28

    申请人： Dieter Neuschafer ,  Gert Ludwig Duveneck ,  Michael Pawlak ,  Uwe Pieles ,  Wolfgang Budach

    发明人： Dieter Neuschafer ,  Gert Ludwig Duveneck ,  Michael Pawlak ,  Uwe Pieles ,  Wolfgang Budach

    IPC分类号： G01N21/64 ,  G01N21/05 ,  G01N21/27 ,  G01N21/55 ,  G01N21/76 ,  G01N21/77 ,  G02B6/00

    CPC分类号： G01N21/648 ,  G01N21/6452 ,  G01N21/7703 ,  G01N2021/0346 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N21/05

    摘要： The invention relates to a sensor platform based on at least two planar, separate, inorganic dielectric waveguiding regions on a common substrate and to a method for the parallel evanescent excitation and detection of the luminescence of identical or different analytes. The invention relates also to a modified sensor platform that consists of the sensor platform having the planar, separate, inorganic dielectric waveguiding regions and one or more organic phases immobilised thereon. A further subject of the invention is the use of the sensor platform or of the modified sensor platform in a luminescence detection method for quantitative affinity sensing and for the selective quantitative determination of luminescent constituents of optically opaque solutions.

    摘要翻译： PCT No.PCT / EP96 / 01817 Sec。 371日期1997年10月28日第 102（e）1997年10月28日PCT PCT 1996年5月2日PCT公布。 公开号WO96 / 35940 日期1996年11月14日本发明涉及基于公共衬底上的至少两个平面，分离的无机介电波导区域的传感器平台以及用于平行ev逝激发和检测相同或不同分析物的发光的方法。 本发明还涉及一种由传感器平台组成的改进的传感器平台，传感器平台具有平面，分离的无机介质波导区域和固定在其上的一个或多个有机相。 本发明的另一个主题是在用于定量亲和力感测的发光检测方法中以及用于选择性定量确定光学不透明溶液的发光成分的传感器平台或修改的传感器平台的使用。

    Flow cell array and the utilization thereof for multianalyte determination
    9.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 失效
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US07678565B2

    公开(公告)日：2010-03-16

    申请号：US12071526

    申请日：2008-02-21

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Grating waveguide structure for reinforcing an excitation field and use thereof
    10.
    发明申请
    Grating waveguide structure for reinforcing an excitation field and use thereof 审中-公开
    用于加强激励场的光栅波导结构及其用途

    公开(公告)号：US20090224173A1

    公开(公告)日：2009-09-10

    申请号：US12318568

    申请日：2008-12-31

    申请人： Gert Ludwig Duveneck ,  Martin Andreas Bopp ,  Michael Pawlak ,  Markus Ehrat ,  Gerd Marowsky

    发明人： Gert Ludwig Duveneck ,  Martin Andreas Bopp ,  Michael Pawlak ,  Markus Ehrat ,  Gerd Marowsky

    IPC分类号： G01J1/58 ,  G02F1/01

    CPC分类号： G01N21/648 ,  G01N21/6428 ,  G01N21/774 ,  G01N2021/6419 ,  G01N2021/7786 ,  G02B6/124

    摘要： The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.

    摘要翻译： 本发明涉及一种基于具有比层（a）折射率低的第二光学透明层（b）上具有第一光学透明层（a）的平面薄膜波导的光栅波导结构的可变实施例， 以及在层（a）中调制的光栅结构（c），其中以共耦合角度照射到层（a）中的激发光的强度在层（a）上至少增加100倍，并且在层 （a），至少在光栅结构（c）的区域中，与衬底表面上的所述激发光的强度相比较，而不会激发激发光的耦合。 本发明还涉及具有激发光源和根据本发明的光栅波导结构的实施例的光学系统，以及用于增强激发光强度的方法及其在生物分析检测过程中的用途， 线性光学或电信或通信行业。