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公开(公告)号：US06604054B2
公开(公告)日：2003-08-05
申请号：US09794255
申请日：2001-02-28
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F15075
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译： 用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极， 与第一电极电隔离并设置在探针的远端。 振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。 通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。 可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。
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公开(公告)号：US06851453B2
公开(公告)日：2005-02-08
申请号：US10425615
申请日：2003-04-30
申请人： James H. Lipscomb , Anna Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： Larry Jurik
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译： 用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极， 与第一电极电隔离并设置在探针的远端。 振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。 通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。 可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。
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公开(公告)号：US5829721A
公开(公告)日：1998-11-03
申请号：US834533
申请日：1997-04-04
CPC分类号： A47B21/0371
摘要： A number of embodiments of a support for a portion of a limb of a user are described. In one embodiment, the support comprises a frame, and a platform movably connected with the frame such that the platform is variably positionable with respect to the frame. A supporting member is constructed to simultaneously support a wrist and a portion of an arm of the user. A supporting member bearing structure connects the platform with the supporting member such that the supporting member is multi-directionally movable with respect to the frame and the platform.
摘要翻译： 描述了用户对肢体的一部分的支持的多个实施例。 在一个实施例中，支撑件包括框架和与框架可移动地连接的平台，使得平台相对于框架可变地定位。 支撑构件被构造成同时支撑使用者的手腕和手臂的一部分。 支撑构件承载结构将平台与支撑构件连接，使得支撑构件相对于框架和平台可多方向移动。
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公开(公告)号：US4738534A
公开(公告)日：1988-04-19
申请号：US30931
申请日：1987-03-26
CPC分类号： G01N21/253 , G01J2003/123 , G01N2201/0407 , G01N2201/0826 , Y10S436/807
摘要： A vertical beam spectrophotometer for measuring the light absorption of an assay prepared using standard wet chemistry procedures and conventional solid phase coated bead technology is disclosed. The spectrophotometer measures the absorption of the assay in a conventional reaction cuvette with the bead remaining in the cuvette. The light source of the spectrophotometer illuminates the bead, which diffuses the light into the surrounding assay solution. A lense projects the diffused light onto a photocell which converts it into an electrical signal having magnitude related to the light absorption of the assay. The signal is processed in a known manner by conventional processing circuitry to obtain an absorption value.
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公开(公告)号：US5275951A
公开(公告)日：1994-01-04
申请号：US939570
申请日：1992-09-03
IPC分类号： G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G01F23/00 , G01F23/28
CPC分类号： G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G02B7/28 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G01N35/1004 , Y10T137/7306 , Y10T436/115831
摘要： An apparatus is provided which includes a reaction cartridge having a plurality of reaction wells having different reagents disposed thereon, at least one well adapted to receive a sample, a well containing particles adapted to bind to the sample and which have the capability of being separated from cells which are not bound to the separation particles and at least one fluorophore adapted to bind to a specific type of cell in the sample, and a wash area adapted for washing a probe. An image forming device is provided to detect images which indicate whether specific reactions have occurred in each of the reaction wells. The apparatus also includes a mechanism for dispensing and aspirating liquids including a mechanism for detecting liquid levels. The device further includes logic for analyzing the information received from the image detection apparatus and processing the information to generate a visual indication of the results of the assays being performed. A microprocessor is provided to assist in the operation of the device as well as in the image processing.
摘要翻译： 提供了一种装置，其包括具有多个反应孔的反应筒，反应孔具有设置在其上的不同试剂，至少一个适于接收样品的孔，含有适于结合样品的颗粒的孔，并具有与样品分离的能力 不结合分离颗粒的细胞和至少一种适于结合样品中特定类型的细胞的荧光团和适于洗涤探针的洗涤区域。 提供图像形成装置以检测指示每个反应孔中是否发生特定反应的图像。 该装置还包括用于分配和抽吸液体的机构，包括用于检测液位的机构。 该装置还包括用于分析从图像检测装置接收的信息并处理信息以生成正在执行的测定结果的视觉指示的逻辑。 提供微处理器以帮助设备的操作以及图像处理。
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公开(公告)号：US06914555B2
公开(公告)日：2005-07-05
申请号：US10426655
申请日：2003-05-01
申请人： James H. Lipscomb , Anna Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： Larry Jurik
IPC分类号： G01F23/26 , G01N35/08 , G01N35/10 , G01F23/284
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译： 用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极， 与第一电极电隔离并设置在探针的远端。 振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。 通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。 可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。
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公开(公告)号：US06663353B2
公开(公告)日：2003-12-16
申请号：US10214158
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译： 用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极， 与第一电极电隔离并设置在探针的远端。 振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。 通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。 可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。
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公开(公告)号：US06658946B2
公开(公告)日：2003-12-09
申请号：US10214161
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant device for detecting fluid flow through the conduit.
摘要翻译： 用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极， 与第一电极电隔离并设置在探针的远端。 振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。 通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。 可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的辅助冗余装置。
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