公开(公告)号：US07235592B2

公开(公告)日：2007-06-26

申请号：US10962975

申请日：2004-10-12

申请人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg ,  Jeffrey W. Ruberti ,  Niels Abt

发明人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg ,  Jeffrey W. Ruberti ,  Niels Abt

IPC分类号： C08F2/46

CPC分类号： C08J3/28 ,  C08J2329/04 ,  Y10S524/916

摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

摘要翻译： 本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。 所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。 根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。 所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

公开(公告)号：US20060079597A1

公开(公告)日：2006-04-13

申请号：US10962975

申请日：2004-10-12

申请人： Orhun Muratoglu ,  Stephen Spiegelberg ,  Jeffrey Ruberti ,  Niels Abt

发明人： Orhun Muratoglu ,  Stephen Spiegelberg ,  Jeffrey Ruberti ,  Niels Abt

IPC分类号： B29D11/00

CPC分类号： C08J3/28 ,  C08J2329/04 ,  Y10S524/916

摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

摘要翻译： 本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。 所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。 根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。 所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

公开(公告)号：US20070059334A1

公开(公告)日：2007-03-15

申请号：US11465743

申请日：2006-08-18

申请人： Niels Abt ,  Werner Schneider-Storrer

发明人： Niels Abt ,  Werner Schneider-Storrer

IPC分类号： A61F2/28 ,  H01J37/30 ,  A61K31/355 ,  A61F2/00

CPC分类号： C08J3/28 ,  A61K31/355 ,  A61L27/16 ,  A61L27/44 ,  A61L27/505 ,  C08J3/24 ,  C08J7/123 ,  C08J2323/06 ,  C08K5/005 ,  C08K5/1545 ,  C08L23/04 ,  C08L23/06 ,  C08L2205/02 ,  C08L2207/068 ,  C08L2312/06 ,  C08L2314/02 ,  Y10T428/269

摘要： The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E prior to irradiating the UHMWPE blend with electron beam radiation at a sufficient radiation dose rate to induce crosslinking. The crosslinked UHMWPE blend may be incorporated into a variety of implants, and in particular, into endoprosthetic joint replacements

摘要翻译： 本发明通常提供可植入制品和从由维生素E稳定的交联的超高分子量聚乙烯（“UHMWPE”）混合物形成可植入制品的方法。交联的UHMWPE共混物可以通过在辐照之前组合UHMWPE材料和维生素E来制备 UHMWPE与电子束辐射以足够的辐射剂量率混合以诱导交联。 交联的UHMWPE共混物可以掺入各种植入物中，特别是并入到假体内关节置换中

公开(公告)号：US20090175919A1

公开(公告)日：2009-07-09

申请号：US11969591

申请日：2008-01-04

申请人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

发明人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

IPC分类号： A61L27/14 ,  C08F120/10 ,  C08F116/06

CPC分类号： A61L27/52 ,  A61F2/32 ,  A61F2/442 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30673 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61L27/26 ,  A61L2430/06 ,  C08L33/26

摘要： The present invention provides a hydrogel composition comprising at least one polymer with functional groups including alcohol groups, acid groups, and amide groups and where the ratio of the functional alcohol groups to functional acid groups in the hydrogel composition ranges from about 16:1 to about 3:2. The present invention also provides a method of repairing an articulating surface in a body using the inventive composition. The inventive hydrogel composition is created by blending two or more polymers to achieve the desired ratio of functional groups, reacting at least one polymer with a reagent that results in the formation of alcohol, acid, and/or amide functional groups of the desired ratio, and/or polymerizing at least one monomer to achieve the desired ratio of functional groups.

摘要翻译： 本发明提供一种水凝胶组合物，其包含至少一种具有包括醇基，酸基和酰胺基团的官能团的聚合物，并且其中水凝胶组合物中官能醇基团与官能酸基团的比例为约16:1至约 3：2。 本发明还提供了使用本发明的组合物修复身体中的关节表面的方法。 本发明的水凝胶组合物是通过混合两种或更多种聚合物来实现所需比例的官能团，使至少一种聚合物与导致形成所需比例的醇，酸和/或酰胺官能团的试剂反应产生的， 和/或聚合至少一种单体以达到所需的官能团比例。

公开(公告)号：US08034362B2

公开(公告)日：2011-10-11

申请号：US11969591

申请日：2008-01-04

申请人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

发明人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

IPC分类号： A61L27/14 ,  C08F120/10 ,  C08F116/06

CPC分类号： A61L27/52 ,  A61F2/32 ,  A61F2/442 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30673 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61L27/26 ,  A61L2430/06 ,  C08L33/26

摘要： The present invention provides a hydrogel composition comprising at least one polymer with functional groups including alcohol groups, acid groups, and amide groups and where the ratio of the functional alcohol groups to functional acid groups in the hydrogel composition ranges from about 16:1 to about 3:2. The present invention also provides a method of repairing an articulating surface in a body using the inventive composition. The inventive hydrogel composition is created by blending two or more polymers to achieve the desired ratio of functional groups, reacting at least one polymer with a reagent that results in the formation of alcohol, acid, and/or amide functional groups of the desired ratio, and/or polymerizing at least one monomer to achieve the desired ratio of functional groups.

摘要翻译： 本发明提供一种水凝胶组合物，其包含至少一种具有包括醇基，酸基和酰胺基团的官能团的聚合物，并且其中水凝胶组合物中官能醇基团与官能酸基团的比例为约16:1至约 3：2。 本发明还提供了使用本发明的组合物修复身体中的关节表面的方法。 本发明的水凝胶组合物是通过混合两种或更多种聚合物来实现所需比例的官能团，使至少一种聚合物与导致形成所需比例的醇，酸和/或酰胺官能团的试剂反应产生的， 和/或聚合至少一种单体以达到所需的官能团比例。