公开(公告)号：US20080226691A1

公开(公告)日：2008-09-18

申请号：US12130287

申请日：2008-05-30

Applicant: Bryan Monro Armitage ,  Ira ISON ,  Mark FULMER ,  Sean KERR ,  Michael LEHMICKE ,  Patrick LEAMY ,  William SCHIFFER

Inventor： Bryan Monro Armitage ,  Ira ISON ,  Mark FULMER ,  Sean KERR ,  Michael LEHMICKE ,  Patrick LEAMY ,  William SCHIFFER

IPC: A61L24/04

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Abstract translation: 本发明一般涉及可植入组合物及其制备方法，其含有钙盐组分，任选的软化骨，多个离散纤维，任选的流动添加剂，以及可选地连续的增强纤维或有组织纤维阵列 以网格的形式。 有利地，离散纤维具有约50:1至约1000:1的特定纵横比（长度/直径）。 添加少量离散纤维和/或连续增强纤维或纤维网可导致某些机械性能的急剧增加，包括弯曲强度，弯曲韧性和/或螺纹拔出强度。

公开(公告)号：US20050131458A1

公开(公告)日：2005-06-16

申请号：US10913511

申请日：2004-08-09

Applicant: Christopher Batich ,  Matthew Eadens ,  Robert Mericle ,  Matthew Burry ,  Courtney Watkins ,  Swadeshmukul Santra ,  Patrick Leamy

Inventor： Christopher Batich ,  Matthew Eadens ,  Robert Mericle ,  Matthew Burry ,  Courtney Watkins ,  Swadeshmukul Santra ,  Patrick Leamy

IPC: A61B20060101 ,  A61B17/08 ,  A61B17/12 ,  A61K9/00 ,  A61K9/50 ,  A61K9/51 ,  A61K49/04 ,  A61L24/00 ,  A61L24/02 ,  A61L31/02 ,  A61L31/18

CPC classification number: A61L24/02 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12186 ,  A61B2017/00876 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5015 ,  A61K9/5115 ,  A61K9/5153 ,  A61K49/0404 ,  A61K49/0423 ,  A61K49/0485 ,  A61L24/001 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/06 ,  A61L2430/36 ,  B82Y5/00

Abstract: A flowable, biodegradable endovascular embolic composition effective for embolizing a vascular defect consisting essentially of: (a) a biocompatible, biodegradable polymer or polymeric material forming composition; (b) a biocompatible embolic solvent for the polymer or polymer forming composition capable of diffusion into mammalian tissue; (c) biocompatible magnetic particles responsive to a magnetic field; wherein: the polymer or polymeric forming material and solvent are present in the composition in amounts and relative proportions such that (1) the composition is deliverable to a vascular defect site and (2) upon delivery to the site, solidifies into an embolic mass; and the magnetic particles are present in the composition in an amount sufficient to enable the composition being deliverable to the vascular site by a magnetic field. Also disclosed are methods and articles of manufacture embodying the above-described composition.

Abstract translation: 一种可流动的，可生物降解的血管内栓塞组合物，其有效栓塞血管缺损，其基本上由以下组成：（a）生物相容的，可生物降解的聚合物或形成聚合物的组合物; （b）能够扩散入哺乳动物组织的聚合物或聚合物形成组合物的生物相容性栓塞溶剂; （c）响应于磁场的生物相容性磁性颗粒; 其中：聚合物或聚合物形成材料和溶剂以数量和相对比例存在于组合物中，使得（1）组合物可输送到血管缺损部位，和（2）在递送至部位后，固化成栓塞体; 并且磁性颗粒以足以使组合物通过磁场输送到血管部位的量存在于组合物中。 还公开了体现上述组合物的方法和制品。

公开(公告)号：US20200237944A1

公开(公告)日：2020-07-30

申请号：US16840041

申请日：2020-04-03

Applicant: Patrick Leamy ,  Qing-Qing Qiu ,  Michael S. Pohle ,  Jason Michael Pomerleau ,  Jerome Connor

Inventor： Patrick Leamy ,  Qing-Qing Qiu ,  Michael S. Pohle ,  Jason Michael Pomerleau ,  Jerome Connor

IPC: A61L2/26 ,  A61L2/00 ,  A61L2/20 ,  A61B50/30

Abstract: Systems for sterilization of tissues, including acellular tissue matrices, comprising a package having a portion permeable to supercritical carbon dioxide and a portion impermeable to moisture are described. Methods of sterilizing acellular tissue matrices from soft tissues or demineralized bone are provided.

公开(公告)号：US08057595B2

公开(公告)日：2011-11-15

申请号：US12611716

申请日：2009-11-03

Applicant: Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

Inventor： Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

IPC: C04B12/02 ,  C04B28/14 ,  C09K3/00

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Abstract translation: 本发明一般涉及可植入组合物及其制备方法，其含有钙盐组分，任选的软化骨，多个离散纤维，任选的流动添加剂，以及可选地连续的增强纤维或有组织纤维阵列 以网格的形式。 有利地，离散纤维具有约50:1至约1000:1的特定纵横比（长度/直径）。 添加少量离散纤维和/或连续增强纤维或纤维网可导致某些机械性能的急剧增加，包括弯曲强度，弯曲韧性和/或螺纹拔出强度。

公开(公告)号：US07628851B2

公开(公告)日：2009-12-08

申请号：US12130287

申请日：2008-05-30

Applicant: Bryan Monro Armitage ,  Ira C Ison ,  Mark Thomas Fulmer ,  Sean Hamilton Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

Inventor： Bryan Monro Armitage ,  Ira C Ison ,  Mark Thomas Fulmer ,  Sean Hamilton Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

IPC: A61F2/28

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

公开(公告)号：US07494950B2

公开(公告)日：2009-02-24

申请号：US10936188

申请日：2004-09-07

Applicant: Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

Inventor： Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

IPC: A61F2/28

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Abstract translation: 本发明一般涉及可植入组合物及其制备方法，其含有钙盐组分，任选的软化骨，多个离散纤维，任选的流动添加剂，以及可选地连续的增强纤维或有组织纤维阵列 以网格的形式。 有利地，离散纤维具有约50:1至约1000:1的特定纵横比（长度/直径）。 添加少量离散纤维和/或连续增强纤维或纤维网可导致某些机械性能的急剧增加，包括弯曲强度，弯曲韧性和/或螺纹拔出强度。

公开(公告)号：US20100048763A1

公开(公告)日：2010-02-25

申请号：US12611716

申请日：2009-11-03

Applicant: Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

Inventor： Bryan Monro Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

IPC: A61F2/00

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Abstract translation: 本发明一般涉及可植入组合物及其制备方法，其含有钙盐组分，任选的软化骨，多个离散纤维，任选的流动添加剂，以及可选地连续的增强纤维或有组织纤维阵列 以网格的形式。 有利地，离散纤维具有约50:1至约1000:1的特定纵横比（长度/直径）。 添加少量离散纤维和/或连续增强纤维或纤维网可导致某些机械性能的急剧增加，包括弯曲强度，弯曲韧性和/或螺纹拔出强度。

公开(公告)号：US20050208094A1

公开(公告)日：2005-09-22

申请号：US10936188

申请日：2004-09-07

Applicant: Bryan Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

Inventor： Bryan Armitage ,  Ira Ison ,  Mark Fulmer ,  Sean Kerr ,  Michael Lehmicke ,  Patrick Leamy ,  William Schiffer

IPC: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/00 ,  A61L27/42 ,  A61L27/46 ,  A61L27/50

CPC classification number: A61K31/74 ,  A61K33/06 ,  A61K33/42 ,  A61L24/001 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61K2300/00

Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.

Abstract translation: 本发明一般涉及可植入组合物及其制备方法，其含有钙盐组分，任选的软化骨，多个离散纤维，任选的流动添加剂，以及可选地连续的增强纤维或有组织纤维阵列 以网格的形式。 有利地，离散纤维具有约50:1至约1000:1的特定纵横比（长度/直径）。 添加少量离散纤维和/或连续增强纤维或纤维网可导致某些机械性能的急剧增加，包括弯曲强度，弯曲韧性和/或螺纹拔出强度。

公开(公告)号：US5590245A

公开(公告)日：1996-12-31

申请号：US294030

申请日：1994-08-24

Applicant: Patrick Leamy ,  Alan Leamy ,  John Gillin

Inventor： Patrick Leamy ,  Alan Leamy ,  John Gillin

IPC: G06F3/12 ,  H04N1/00 ,  H04N1/32 ,  G06F13/00

CPC classification number: H04N1/32561 ,  G06F3/12 ,  H04N1/00204 ,  H04N2201/0081 ,  H04N2201/0082 ,  H04N2201/0086 ,  H04N2201/0087

Abstract: An image processing method is carried out by a system (1) where a client system (2) automatically logs client data and retrieves image data to produce a job file which is automatically transmitted to a modem (10) of an image processing system (3). A control image processor (11) automatically monitors the job file and carries out routing operations and also supervisor notification operations to ensure efficient and effective implementation of the image processing method as required by the client. Each of the workstations (18, 19, 20) is capable of automatic configuration for particular job types by setting of image processing parameter values such as memory and virtual memory settings.

Abstract translation: 一种图像处理方法由系统（1）执行，其中客户端系统（2）自动记录客户端数据并检索图像数据以产生自动发送到图像处理系统（3）的调制解调器（10）的作业文件 ）。 控制图像处理器（11）自动监视作业文件并执行路由操作以及管理程序通知操作，以确保客户端所要求的图像处理方法的有效和有效的实现。 通过设置诸如存储器和虚拟存储器设置的图像处理参数值，每个工作站（18,19,20）能够对特定作业类型进行自动配置。