公开(公告)号：US06599926B2

公开(公告)日：2003-07-29

申请号：US09887936

申请日：2001-06-22

申请人： Donald J. P. Pinto ,  Mimi L. Quan ,  Francis J. Woerner

发明人： Donald J. P. Pinto ,  Mimi L. Quan ,  Francis J. Woerner

IPC分类号： A61K3141

CPC分类号： C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

摘要： The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of factor Xa.

公开(公告)号：US06506771B2

公开(公告)日：2003-01-14

申请号：US09887850

申请日：2001-06-22

申请人： Donald J. P. Pinto ,  Mimi L. Quan ,  Francis J. Woerner ,  Renhua Li

发明人： Donald J. P. Pinto ,  Mimi L. Quan ,  Francis J. Woerner ,  Renhua Li

IPC分类号： C07D47104

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

摘要翻译： 本申请描述了可用作因子Xa抑制剂的杂芳基 - 苯基杂双环及其衍生物或其药学上可接受的盐形式。

公开(公告)号：US5506355A

公开(公告)日：1996-04-09

申请号：US269281

申请日：1994-06-30

申请人： Prabhakar K. Jadhav ,  Wayne F. Daneker ,  Francis J. Woerner

发明人： Prabhakar K. Jadhav ,  Wayne F. Daneker ,  Francis J. Woerner

IPC分类号： C12N9/99 ,  A61K31/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/451 ,  A61K31/505 ,  A61K31/55 ,  A61K31/554 ,  A61P31/12 ,  A61P43/00 ,  C07C49/723 ,  C07C49/737 ,  C07C49/747 ,  C07D211/74 ,  C07D211/76 ,  C07D223/10 ,  C07D223/12 ,  C07D239/10 ,  C07D243/04 ,  C07D245/02 ,  C07D247/02 ,  C07D267/06 ,  C07D279/02 ,  C07D281/02 ,  C07D285/16 ,  C07D285/36 ,  C07D313/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07D521/00 ,  C07F9/6584 ,  C07D513/04

CPC分类号： C07D239/10 ,  C07C49/723 ,  C07C49/747 ,  C07D211/76 ,  C07D223/10 ,  C07D223/12 ,  C07D231/12 ,  C07D233/56 ,  C07D243/04 ,  C07D245/02 ,  C07D249/08 ,  C07D267/06 ,  C07D279/02 ,  C07D281/02 ,  C07D285/16 ,  C07D285/36 ,  C07D313/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07F9/65848

摘要： The present invention discloses processes for the preparation of substituted cyclic sulfamides which are useful as intermediates for the synthesis of cyclic sulfamide human immunodeficiency virus (HIV) protease inhibitors. Such substituted cyclic sulfamide intermediates contain a cyclic acetal-protected diol.

摘要翻译： 本发明公开了制备可用作合成环状磺酰胺人类免疫缺陷病毒（HIV）蛋白酶抑制剂的中间体的取代的环状磺酰胺的方法。 这种取代的环状磺酰胺中间体含有环状缩醛保护的二醇。

公开(公告)号：US09175315B2

公开(公告)日：2015-11-03

申请号：US13162868

申请日：2011-06-17

申请人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J Woerner

发明人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J Woerner

IPC分类号： C12P7/62 ,  C12P7/22 ,  C12P7/16 ,  C12N1/00 ,  C12N1/12 ,  C07H21/04 ,  B01D3/00 ,  B01D21/26 ,  C07C29/86 ,  C11B1/02 ,  C11B13/00 ,  C12M1/00 ,  C12P7/64 ,  C12P7/18

CPC分类号： C12P7/16 ,  A23K10/38 ,  B01D3/002 ,  B01D11/0492 ,  B01D21/26 ,  B01D21/262 ,  C07C29/86 ,  C11B1/025 ,  C11B13/00 ,  C12F3/10 ,  C12M1/00 ,  C12M21/12 ,  C12M45/04 ,  C12M45/09 ,  C12N1/14 ,  C12N15/00 ,  C12P7/18 ,  C12P7/6418 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02W30/74

摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.

公开(公告)号：US20120156738A1

公开(公告)日：2012-06-21

申请号：US13162868

申请日：2011-06-17

申请人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

发明人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

IPC分类号： C12P7/62 ,  C12N1/19 ,  C12N1/00 ,  C12P7/02 ,  C12P7/16

CPC分类号： C12P7/16 ,  A23K10/38 ,  B01D3/002 ,  B01D11/0492 ,  B01D21/26 ,  B01D21/262 ,  C07C29/86 ,  C11B1/025 ,  C11B13/00 ,  C12F3/10 ,  C12M1/00 ,  C12M21/12 ,  C12M45/04 ,  C12M45/09 ,  C12N1/14 ,  C12N15/00 ,  C12P7/18 ,  C12P7/6418 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02W30/74

摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.

公开(公告)号：US09206448B2

公开(公告)日：2015-12-08

申请号：US13162828

申请日：2011-06-17

申请人： Douglas Robert Anton ,  Jelena Cirakovic ,  Bruce A. Diner ,  Michael Charles Grady ,  Francis J. Woerner

发明人： Douglas Robert Anton ,  Jelena Cirakovic ,  Bruce A. Diner ,  Michael Charles Grady ,  Francis J. Woerner

IPC分类号： C12P1/00 ,  C12N9/00 ,  C12N15/00 ,  C12N1/14 ,  C07H21/04 ,  C12P7/16 ,  B01D3/00 ,  B01D21/26 ,  C07C29/86 ,  C11B1/02 ,  C11B13/00 ,  C12M1/00 ,  C12P7/64 ,  C12P7/18

CPC分类号： C12P7/16 ,  A23K10/38 ,  B01D3/002 ,  B01D11/0492 ,  B01D21/26 ,  B01D21/262 ,  C07C29/86 ,  C11B1/025 ,  C11B13/00 ,  C12F3/10 ,  C12M1/00 ,  C12M21/12 ,  C12M45/04 ,  C12M45/09 ,  C12N1/14 ,  C12N15/00 ,  C12P7/18 ,  C12P7/6418 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02W30/74

摘要： In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be chemically converted into a reaction product, such as fatty acids, fatty alcohols, fatty amides, fatty acid methyl esters, fatty acid glycol esters, and hydroxylated triglycerides, and mixtures thereof, which forms a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be chemically converting into the fermentation product extractant. The oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be chemically converted to a fermentation product extractant, which can then contacted with a fermentation product comprising a product alcohol, whereby the product alcohol is separated from the fermentation product.

摘要翻译： 在酒精发酵过程中，将来自生物质的油化学转化成可从发酵液中原位除去产物醇如丁醇的萃取剂。 油中的甘油酯可以化学转化成反应产物，例如脂肪酸，脂肪醇，脂肪酰胺，脂肪酸甲酯，脂肪酸二醇酯和羟基化甘油三酸酯及其混合物，其形成发酵产物提取剂，其具有 产物醇的分配系数大于产物醇的生物质油的分配系数。 来自醇发酵方法的原料的油可以化学转化成发酵产物萃取剂。 在将原料进料到发酵容器之前，油可以与原料分离，并且将分离的油化学转化成发酵产物萃取剂，然后可将其与包含产物醇的发酵产物接触，由此产物醇 与发酵产物分离。

公开(公告)号：US09040263B2

公开(公告)日：2015-05-26

申请号：US13193147

申请日：2011-07-28

申请人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

发明人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

IPC分类号： C12P7/64 ,  A23K1/00 ,  A23K1/06 ,  C12P7/16 ,  C12P7/62

CPC分类号： A23K1/007 ,  A23K10/12 ,  A23K10/38 ,  C12P7/16 ,  C12P7/62 ,  C12P7/649 ,  C12P2203/00 ,  Y02E50/10 ,  Y02E50/13 ,  Y02P60/873

摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.

摘要翻译： 醇发酵方法和组合物，其包括通过在发酵培养基中与产物醇与羧酸（例如，脂肪酸）和能够酯化产物醇（例如丁醇）的催化剂（例如脂肪酶）酯化产生醇酯， 与羧酸形成醇酯。 醇酯可以​​从发酵培养基中提取，并从醇酯中回收产物醇。 羧酸也可以用作从发酵培养基中除去醇酯的提取剂。

公开(公告)号：US20110312044A1

公开(公告)日：2011-12-22

申请号：US13162828

申请日：2011-06-17

申请人： DOUGLAS ROBERT ANTON ,  JELENA CIRAKOVIC ,  BRUCE A. DINER ,  MICHAEL CHARLES GRADY ,  FRANCIS J. WOERNER

发明人： DOUGLAS ROBERT ANTON ,  JELENA CIRAKOVIC ,  BRUCE A. DINER ,  MICHAEL CHARLES GRADY ,  FRANCIS J. WOERNER

IPC分类号： C12P7/04 ,  C12N1/19 ,  C12N1/15 ,  C12P13/02 ,  C12P7/64 ,  C07C29/04 ,  C12P7/06 ,  C11C3/00 ,  C11C1/02 ,  C07C29/147 ,  C11C3/10 ,  C12N1/21 ,  C12P7/16

CPC分类号： C12P7/16 ,  A23K10/38 ,  B01D3/002 ,  B01D11/0492 ,  B01D21/26 ,  B01D21/262 ,  C07C29/86 ,  C11B1/025 ,  C11B13/00 ,  C12F3/10 ,  C12M1/00 ,  C12M21/12 ,  C12M45/04 ,  C12M45/09 ,  C12N1/14 ,  C12N15/00 ,  C12P7/18 ,  C12P7/6418 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02W30/74

摘要： In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be chemically converted into a reaction product, such as fatty acids, fatty alcohols, fatty amides, fatty acid methyl esters, fatty acid glycol esters, and hydroxylated triglycerides, and mixtures thereof, which forms a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be chemically converting into the fermentation product extractant. The oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be chemically converted to a fermentation product extractant, which can then contacted with a fermentation product comprising a product alcohol, whereby the product alcohol is separated from the fermentation product.

摘要翻译： 在酒精发酵过程中，将来自生物质的油化学转化成可从发酵液中原位除去产物醇如丁醇的萃取剂。 油中的甘油酯可以化学转化成反应产物，例如脂肪酸，脂肪醇，脂肪酰胺，脂肪酸甲酯，脂肪酸二醇酯和羟基化甘油三酸酯及其混合物，其形成发酵产物提取剂，其具有 产物醇的分配系数大于产物醇的生物量的油的分配系数。 来自醇发酵方法的原料的油可以化学转化成发酵产物萃取剂。 在将原料进料到发酵容器之前，油可以与原料分离，并且将分离的油化学转化成发酵产物萃取剂，然后可将其与包含产物醇的发酵产物接触，由此产物醇 与发酵产物分离。

公开(公告)号：US20120208246A1

公开(公告)日：2012-08-16

申请号：US13193147

申请日：2011-07-28

申请人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

发明人： Douglas Robert Anton ,  Stephane Francois Bazzana ,  Keith H. Burlew ,  Jelena Cirakovic ,  Robert Dicosimo ,  Bruce A. Diner ,  Michael Charles Grady ,  Brian Michael Roesch ,  Francis J. Woerner

IPC分类号： C12P7/64 ,  C12N9/16 ,  A23K1/06 ,  C12P7/16

CPC分类号： A23K1/007 ,  A23K10/12 ,  A23K10/38 ,  C12P7/16 ,  C12P7/62 ,  C12P7/649 ,  C12P2203/00 ,  Y02E50/10 ,  Y02E50/13 ,  Y02P60/873

摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.

摘要翻译： 醇发酵方法和组合物，其包括通过在发酵培养基中与产物醇与羧酸（例如，脂肪酸）和能够酯化产物醇（例如丁醇）的催化剂（例如脂肪酶）酯化产生醇酯， 与羧酸形成醇酯。 醇酯可以​​从发酵培养基中提取，并从醇酯中回收产物醇。 羧酸也可以用作从发酵培养基中除去醇酯的提取剂。