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    Peptide templates for nanoparticle synthesis obtained through PCR-driven phage display method
    3.
    发明申请
    Peptide templates for nanoparticle synthesis obtained through PCR-driven phage display method 审中-公开
    通过PCR驱动的噬菌体展示法获得纳米颗粒合成的肽模板

    公开(公告)号：US20060172282A1

    公开(公告)日：2006-08-03

    申请号：US11045488

    申请日：2005-01-31

    Applicant: Rajesh Naik ,  Morley Stone ,  Daniel Carter

    Inventor： Rajesh Naik ,  Morley Stone ,  Daniel Carter

    IPC: C40B40/08 ,  C40B30/02

    CPC classification number: C12N15/1037 ,  B82Y30/00 ,  C07K7/08

    Abstract: A method is provided for identifying and isolating peptides capable of binding of inorganic materials such as silica, silver, germanium, cobalt, iron, or oxides thereof, or other materials on a nanometric scale such as carbon nanotubes, using a combinatorial phage display peptide library and a polymerase-chain reaction (PCR) step to obtain specific amino acids sequences. In the method of the invention, a combinatorial phage display library is used to isolate and select the desired binding peptides by a series of steps of target binding of phage with the nanometric material of interest, elution and purification of the bound phages, and amplification using PCR to determine the sequences of phages producing the desired binding peptides. The binding peptides of the invention are particularly advantageous in that they may be used as templates to guide the development of useful structures on a nanometric scale.

    Abstract translation: 提供了一种方法，用于使用组合噬菌体展示肽文库鉴定和分离能够结合无机材料如二氧化硅，银，锗，钴，铁或其氧化物或纳米级别的其它材料的肽，例如碳纳米管 和聚合酶链式反应（PCR）步骤，以获得特定的氨基酸序列。 在本发明的方法中，组合噬菌体展示文库用于通过目标结合噬菌体与感兴趣的纳米材料，洗脱和纯化结合的噬菌体的一系列步骤来分离和选择所需的结合肽，并使用 PCR以确定产生所需结合肽的噬菌体的序列。 本发明的结合肽是特别有利的，因为它们可以用作模板以指导在纳米尺度上开发有用的结构。

    Process for preparation of gabapentin
    4.
    发明申请
    Process for preparation of gabapentin 失效
    加巴喷丁的制备方法

    公开(公告)号：US20050119503A1

    公开(公告)日：2005-06-02

    申请号：US10497899

    申请日：2002-11-18

    Applicant: Jagdish Saigal ,  Rajender Gupta ,  Rajesh Naik ,  Araddy Rajshekhar ,  Rajesh Joshi

    Inventor： Jagdish Saigal ,  Rajender Gupta ,  Rajesh Naik ,  Araddy Rajshekhar ,  Rajesh Joshi

    IPC: A61K31/195 ,  C07C227/38 ,  C07C227/42

    CPC classification number: C07C227/42 ,  C07C229/28

    Abstract: A process for producing Gabapentin, (1-(anminomethyl)-1-cyclohexaneacetic acid) from Gabapentin hydrochloride salt. In the process the Gabapentin hydrochloride is converted to Gabapentin using inorganic base such as Barium hydroxide. Gabapentin hydrochloride is converted to Gabapentin sulfate which in turn is converted to free base using Barium hydroxide. The process is directed to improvement in the manufacture of Gabapentin which would be industrially feasible and effective Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy. The above process involves simple steps and avoid the problems of the known art. In particular the process avoids severe conditions and/or complexities and can be readily adopted for industrial application. The process provides for good yield and does not involve lengthy extended process steps. It is cost-effective and can be carried out involving simple ingredients and steps of manufacture.

    Abstract translation: 从加巴喷丁盐酸盐制备加巴喷丁（1-（氨基甲基）-1-环己烷乙酸）的方法。 在该过程中，使用无机碱如氢氧化钡将盐酸加巴喷丁转化为加巴喷丁。 将加巴喷丁盐酸盐转化为硫酸氢巴比坦，然后使用氢氧化钡将其转化为游离碱。 本发明涉及在工业上可行且有效的加巴喷丁的制造方面的改进。本发明方法获得的加巴喷丁适合作为特别是治疗脑疾病如癫痫的药物。 上述过程涉及简单的步骤并且避免了已知技术的问题。 特别地，该方法避免了苛刻的条件和/或复杂性，并且可以容易地用于工业应用。 该方法提供良好的产率，并不涉及冗长的扩展工艺步骤。 它具有成本效益，可以进行简单的成分和制造步骤。

    Method and apparatus for use of thermally switching proteins in sensing and detecting devices
    5.
    发明申请
    Method and apparatus for use of thermally switching proteins in sensing and detecting devices 审中-公开
    用于在感测和检测装置中热切换蛋白质的方法和装置

    公开(公告)号：US20070295907A1

    公开(公告)日：2007-12-27

    申请号：US11724178

    申请日：2007-03-15

    Applicant: Lawrence Brott ,  Rajesh Naik ,  Morley Stone ,  Daniel Carter

    Inventor： Lawrence Brott ,  Rajesh Naik ,  Morley Stone ,  Daniel Carter

    IPC: G01J5/00

    CPC classification number: H01L51/428 ,  B82Y10/00 ,  G01J5/20 ,  G01N21/3563 ,  G01N25/72 ,  H01L27/305 ,  H01L27/307 ,  H01L51/0093 ,  H01L51/4206 ,  H01L51/4253 ,  Y02E10/549

    Abstract: An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium, means for recording changes in conductivity or resistance of the conductive film or gel caused by the presence of infrared radiation and its effect on the thermal-sensing protein, and means to analyze the changes in conductivity or resistance in the conductive film caused thereby so as to determine if infrared radiation is present. By virtue of the present invention, a “biomimetic” infrared sensor is provided which can integrate a recombinantly produced thermally sensitive protein in a conductive polymer matrix, such as a film or gel, and provide a low-cost, lightweight, conformable, and disposable infrared detecting device having high sensitivity and excellent dynamic range.

    Abstract translation: 提供了一种用于检测红外辐射的装置和方法，其包括温度感测螺旋线圈蛋白如TIpA，CC1，胶原或肌球蛋白，其结合到沉积在导电介质上的导电膜或凝胶中，用于记录变化的装置 在由红外辐射的存在引起的导电膜或凝胶的电导率或电阻及其对热敏感蛋白的影响，以及分析由此引起的导电膜的导电性或电阻变化的方法，以便确定红外辐射 存在。 凭借本发明，提供了一种“仿生”红外传感器，其可以将重组产生的热敏蛋白质整合到导电聚合物基质例如膜或凝胶中，并且提供低成本，轻质，顺应性和一次性的 红外线检测装置灵敏度高，动态范围优异。

    Entrapment of biomolecules and inorganic nanoparticles by biosilicification
    6.
    发明申请
    Entrapment of biomolecules and inorganic nanoparticles by biosilicification 审中-公开
    生物分子和无机纳米颗粒通过生物硅化作用截留

    公开(公告)号：US20050095690A1

    公开(公告)日：2005-05-05

    申请号：US10803633

    申请日：2004-03-18

    Applicant: Rajesh Naik ,  Morley Stone ,  Jim Spain ,  Heather Luckarift

    Inventor： Rajesh Naik ,  Morley Stone ,  Jim Spain ,  Heather Luckarift

    IPC: C07K17/02 ,  C07K17/06 ,  C12N11/14 ,  C12P3/00 ,  C12P21/04

    CPC classification number: C12N11/14 ,  C07K17/02 ,  C07K17/06 ,  Y02P20/588

    Abstract: A method of immobilizing at least one molecule in a silica matrix to form a biosilicification product. The at least one molecule may be immobilized in the silica matrix at substantially the same time as the silica matrix is formed. The method comprises combining at least one silaffin polypeptide, at least one molecule, and at least one hydroxylated water-soluble derivative to form the biosilicification product. The silaffin polypeptide may be Sil1 protein from C. fusiformis, a fragment of the Sil1 protein, poly-L-lysine, or a synthetic polypeptide having affinity for silica. The at least one molecule may be an enzyme, a protein, a polypeptide, an antibody, an antigen, poly(nucleic) acids, microbial cells, plant cells, or animal cells. The hydroxylated water-soluble derivative may be silicic acid.

    Abstract translation: 将至少一种分子固定在二氧化硅基质中以形成生物硅酸化产物的方法。 基本上与形成二氧化硅基质的同时，至少一个分子可以固定在二氧化硅基质中。 该方法包括组合至少一种烷基多糖，至少一种分子和至少一种羟基化水溶性衍生物以形成生物硅酸化产物。 所述丝质多肽可以是来自梭形梭菌的Sil1蛋白，Sil1蛋白的片段，聚-L-赖氨酸或对二氧化硅具有亲和力的合成多肽。 至少一个分子可以是酶，蛋白质，多肽，抗体，抗原，聚（核酸），微生物细胞，植物细胞或动物细胞。 羟基化的水溶性衍生物可以是硅酸。

    METHOD AND APPARATUS FOR USE OF THERMALLY SWITCHING PROTEINS IN SENSING AND DETECTING DEVICES
    10.
    发明申请
    METHOD AND APPARATUS FOR USE OF THERMALLY SWITCHING PROTEINS IN SENSING AND DETECTING DEVICES 失效
    在传感和检测装置中使用热切换蛋白的方法和装置

    公开(公告)号：US20070037133A1

    公开(公告)日：2007-02-15

    申请号：US10313010

    申请日：2002-12-06

    Applicant: Lawrence Brott ,  Rajesh Naik ,  Morley Stone ,  Daniel Carter

    Inventor： Lawrence Brott ,  Rajesh Naik ,  Morley Stone ,  Daniel Carter

    IPC: C12Q1/00 ,  C07K14/435

    CPC classification number: H01L51/428 ,  B82Y10/00 ,  G01J5/20 ,  G01N21/3563 ,  G01N25/72 ,  H01L27/305 ,  H01L27/307 ,  H01L51/0093 ,  H01L51/4206 ,  H01L51/4253 ,  Y02E10/549

    Abstract: An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance of the conductive film or gel caused by the presence of infrared radiation and the effect of the infrared radiation on the thermal-sensing protein, and means to analyze the changes in conductivity or resistance in the conductive film caused by the infrared radiation so as to determine if infrared radiation is present. By virtue of the present invention, a “biomimetic” infrared sensor is provided which can integrate a recombinantly produced thermally sensitive protein in a conductive polymer matrix, such as a film or gel, so as to provide for the first time a low-cost, lightweight, conformable, and even possibly disposable, infrared detecting device having high sensitivity and excellent dynamic range.

    Abstract translation: 提供了一种用于检测红外辐射的装置和方法，其包括温度感测螺旋线圈蛋白，例如TIpA，CC1，胶原或肌球蛋白，结合到沉积到导电介质如电极上的导电膜或凝胶中， 用于记录由红外辐射的存在引起的导电膜或凝胶的电导率或电阻的变化以及红外辐射对热感测蛋白的影响的手段，以及分析导电膜中导电性或电阻变化的手段 通过红外辐射来确定是否存在红外辐射。 凭借本发明，提供了一种“仿生”红外传感器，其可以将重组产生的热敏蛋白整合到导电聚合物基质如膜或凝胶中，以便首次提供低成本， 重量轻，一致，甚至一次性的红外线检测装置具有高灵敏度和优异的动态范围。

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