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公开(公告)号：US07201833B2
公开(公告)日：2007-04-10
申请号：US10307468
申请日：2002-12-02
IPC分类号： G01N33/487
CPC分类号： B01L3/5023 , B01J2219/00286 , B01J2219/00358 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00722 , B01J2219/00725 , B01J2219/00783 , B01J2219/00831 , B01J2219/00853 , B01J2219/0086 , B01L3/502707 , B01L3/50273 , B01L3/502753 , B01L2200/12 , B01L2200/16 , B01L2300/0645 , B01L2300/0825 , B01L2300/10 , B01L2400/0415 , B01L2400/0418 , G01N33/6845 , G01N2035/00158
摘要： The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integral electro-kinetic pumping electrodes. The hydrophilic matrix circuits are enclosed within a gas permeable electrical insulator. The devices are for use in micro-scale bio-analysis, mixture separation and reaction.
摘要翻译： 本发明涉及具有积分流体输入和输出的分析装置和微阵列。 这些器件由平面固相亲水基质电路构成，其包含覆盖整体电动泵浦电极的干化学试剂。 亲水基质电路封闭在透气电绝缘体内。 该装置用于微量生物分析，混合物分离和反应。
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公开(公告)号：US06379883B2
公开(公告)日：2002-04-30
申请号：US09741347
申请日：2000-12-21
申请人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
发明人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
IPC分类号： C12Q100
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
摘要翻译： 化学传感器包括位于扩散层上的酶层，扩散层和分析物阻挡层。 通过在分析物阻挡层中的微细加工形成孔径，以允许控制的分析物通量到扩散层。
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3.发明授权
公开(公告)号：US5605664A
公开(公告)日：1997-02-25
申请号：US546796
申请日：1995-10-23
CPC分类号： G01N33/4925 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/106664 , Y10T436/209163
摘要： Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.
摘要翻译： 公开了一种平衡水溶液的溶解气体组成以反映包含在气体平衡储存器中的预定气体组成的装置和方法。 平衡的含水流体可用于确定流体样品中溶解气体浓度的方法。 在一个实施方案中，所公开的方法用于控制校准流体的平衡气体组成，其又用于测量样品流体（例如整体）中的溶解气体（例如氧气和二氧化碳）的浓度 血液。
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公开(公告)号：US08124026B2
公开(公告)日：2012-02-28
申请号：US12718139
申请日：2010-03-05
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US07722817B2
公开(公告)日：2010-05-25
申请号：US10649683
申请日：2003-08-28
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US6030827A
公开(公告)日：2000-02-29
申请号：US12579
申请日：1998-01-23
申请人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
发明人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
IPC分类号： G01N27/327 , C12Q1/00 , C12M1/40
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
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公开(公告)号：US5789253A
公开(公告)日：1998-08-04
申请号：US816006
申请日：1997-03-10
CPC分类号： G01N33/4925 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/106664 , Y10T436/209163
摘要： An apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.
摘要翻译： 一种用于平衡含水流体的溶解气体组成以反映包含在气体平衡储存器中的预定气体组成的装置和方法。 平衡的含水流体可用于确定流体样品中溶解气体浓度的方法。 在一个实施方案中，该方法用于控制校准物流体的平衡气体组成，其又用于测量样品流体（例如全血）中的溶解气体（例如氧气和二氧化碳）的浓度 。
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公开(公告)号：US20100202926A1
公开(公告)日：2010-08-12
申请号：US12718139
申请日：2010-03-05
CPC分类号： B01L3/50273 , B01L2200/0673 , B01L2200/10 , B01L2300/0816 , B01L2400/0406 , B01L2400/0418 , F04B19/006 , Y10T436/2575
摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.
摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。
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公开(公告)号：US5614416A
公开(公告)日：1997-03-25
申请号：US546797
申请日：1995-10-23
CPC分类号： G01N33/4925 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/106664 , Y10T436/209163
摘要： Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.
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公开(公告)号：US5609824A
公开(公告)日：1997-03-11
申请号：US274387
申请日：1994-07-13
CPC分类号： G01N33/4925 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/106664 , Y10T436/209163
摘要： Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.
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