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27 条记录 (耗时 0.018 秒)

    Method and circuit for bypassing spurious resonance in lumped, distributed and waveguide element networks
    1.
    发明授权
    Method and circuit for bypassing spurious resonance in lumped, distributed and waveguide element networks 有权

    公开(公告)号：US11303259B2

    公开(公告)日：2022-04-12

    申请号：US16689623

    申请日：2019-11-20

    申请人： Richard Snyder

    发明人： Richard Snyder

    IPC分类号： H03H7/01

    摘要： Disclosed herein are methods and circuits that prevent energy that would produce a spurious resonance from lumped, distributed or waveguide circuit elements by using for example a low pass filter with a cut-off below the first spurious resonance frequency and bypassing the energy at frequencies at or above the first spurious resonance frequency through a secondary path. This secondary path is high pass in nature, with a cutoff substantially similar to the low pass filter. The two paths are combined at the common output, using a lowpass matching network.

    Methods for increasing the efficiency of recombinant AAV product
    4.
    发明授权
    Methods for increasing the efficiency of recombinant AAV product 失效
    提高重组AAV产品效率的方法

    公开(公告)号：US06548286B1

    公开(公告)日：2003-04-15

    申请号：US09060102

    申请日：1998-04-14

    申请人： Richard Jude Samulski ,  Xiao Xiao ,  Richard Snyder

    发明人： Richard Jude Samulski ,  Xiao Xiao ,  Richard Snyder

    IPC分类号： C12N701

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152

    摘要： The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titre recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titre rAAV vectors. The invention provides methods for regulating the expression of the AAV REP gene at the transcriptional and post-translational level. The methods and compositions of the invention can be used to produce high titre stocks of rAAV which can be used in gene therapy for the purpose of transferring genetic information into appropriate host cells for the management and correction of human diseases including inherited and acquired disorders.

    摘要翻译： 本发明涉及通过调节AAV REP和CAP蛋白的表达来增加重组AAV（rAAV）的高滴度储备的生产的方法和组合物。 本发明的方法和组合基于AAV REP蛋白的低水平表达增加AAV病毒衣壳蛋白的产生和包装效率的观察，导致产生较高滴度的重组病毒种群。 本发明包括引导AAV REP和CAP蛋白的表达的重组AAV载体，以及这些载体用于产生能产生高滴度rAAV载体的新型稳定细胞系的用途。 本发明提供了在转录和翻译后水平调节AAV REP基因表达的方法。 本发明的方法和组合物可用于生产高滴度的rAAV，其可用于基因治疗，以将遗传信息转移到合适的宿主细胞中，用于管理和矫正包括遗传和获得性疾病在内的人类疾病。

    Duct structure for a cotton harvester
    5.
    发明授权
    Duct structure for a cotton harvester 失效
    棉花收割机的管道结构

    公开(公告)号：US5857908A

    公开(公告)日：1999-01-12

    申请号：US768837

    申请日：1996-12-18

    申请人： Earl Richard Snyder ,  Timothy Allan Meeks ,  Michael J. Covington

    发明人： Earl Richard Snyder ,  Timothy Allan Meeks ,  Michael J. Covington

    IPC分类号： A01D46/08 ,  A01D46/10

    CPC分类号： A01D46/08

    摘要： Cotton harvester multi-piece duct structure for conveying cotton materials between a cotton harvesting row unit, arranged toward a lower end of the duct structure, and an inlet opening of an extendable/retractable basket assembly. Toward an upper end thereof, the duct structure has a distal end operably connected to a remaining portion of the duct structure to allow the distal end of the duct structure to period between an operational position, wherein an outlet end of the duct structure is in general registry with the inlet opening to the basket assembly, and a storage position, wherein the distal end of the duct structure is lowered from the operational position to facilitate transportation of the cotton harvester. A lock mechanism is also disclosed for releasably fastening the distal end of the duct structure in an operational position relative to the remaining portion of the duct structure.

    摘要翻译： 棉花收割机多件式管道结构，用于在棉花收获行单元之间输送棉花材料，布置成朝向管道结构的下端，以及可伸缩篮组件的入口。 导管结构朝向其上端，其远端可操作地连接到管道结构的剩余部分，以允许管道结构的远端在操作位置之间周期，其中管道结构的出口端一般 与通向篮组件的入口开口对准，以及存储位置，其中管道结构的远端从操作位置降低以便于棉花收割机的运输。 还公开了一种锁定机构，用于将管道结构的远端可释放地紧固在相对于管道结构的剩余部分的操作位置。

    Pulley system powered by loss of buoyancy
    6.
    发明申请
    Pulley system powered by loss of buoyancy 审中-公开

    公开(公告)号：US20100000212A1

    公开(公告)日：2010-01-07

    申请号：US12217382

    申请日：2008-07-03

    申请人： Carl Richard Snyder

    发明人： Carl Richard Snyder

    IPC分类号： F03B17/00

    CPC分类号： F03G3/00 ,  F03B17/025 ,  Y02E10/20

    摘要： The Pulley System Powered by Loss of Buoyancy is a design to configure a buoyant vessel, a pulley, and a counter-weight such that they form a system that can produce a positive work output that can be used to drive gears. The core idea of this design is the use of loss of buoyancy as a power source.The Pulley System Powered by Loss of Buoyancy is a system that can drive gears using loss of buoyancy as the source of power. Industry standard aluminum alloy or carbon fiber composite materials can be used to construct the system.(Refer to FIG. 1.) Vessel A has a floor, 4 walls, and an open top. The vessel is constructed of aluminum alloy or carbon fiber composite material. The vessel is initially buoyant and is placed in a lake, reservoir, or tank with adequate water supply. Vessel A is attached to a counter-weight E via cable that runs through pulleys C and D. Vessel A is also attached via wheels K to rail track G. Electronically activated valves B open and cause Vessel A to be flooded with water. As vessel A sinks, it pulls up counter-weight E and drives pulleys C and D. Vessel A eventually sinks to stop H and the movement of counter-weight E upwards is limited by stop F. Rail track G keeps vessel A aligned vertically as it sinks and rises. Gears can be linked to pulley D and driven during the sinking of vessel A.(Refer to FIG. 2.) The floor of Vessel A is shown in FIG. 2. The floor is divided into 4 sections. Each floor section is connected to its nearest vessel wall via a hinge (L). The portion of each floor section nearest to the hinge (M) is buoyant and lightweight. The portion of each floor section nearest to the center of the floor (N) is 5 times heavier than the rest of the floor section. Electronically controlled latches in the floor release the floor sections at the center once vessel A has sunk and its sinking has been stopped by stop H. The floor sections then swing out and down, with the heavier part of each section (N) sinking down into the water and allowing the floor sections to swing all the way out and down. After that occurs, the vessel can be lifted back up by counter-weight E. When the vessel is mostly out of the water, electrical motors and lifts (O) swing the floor sections back into place and the electrical latches in the floor lock the sections back together. Electronically activated valves B close as the floor sections are lifted back up. The process for sinking the vessel and driving the pulleys can start again.The system produces positive work output that can be used to drive gears attached to pulley D. Externally provided electrical power is needed to drive the electronically controlled valves, electronically controlled floor latches, and electronic floor section lifts.

    System and method for vertical flight planning
    7.
    发明申请
    System and method for vertical flight planning 有权
    垂直飞行计划的系统和方法

    公开(公告)号：US20050283281A1

    公开(公告)日：2005-12-22

    申请号：US10871668

    申请日：2004-06-21

    申请人： Gary Hartmann ,  Michael Jackson ,  Brian O'Laughlin ,  Richard Snyder ,  Rosa Weber

    发明人： Gary Hartmann ,  Michael Jackson ,  Brian O'Laughlin ,  Richard Snyder ,  Rosa Weber

    IPC分类号： G01C21/00 ,  G05D1/00 ,  G05D1/06

    CPC分类号： G05D1/0607 ,  G01C21/00

    摘要： A method for performing performance prediction with respect to a vertical flight plan. A system performs performance prediction with respect to a vertical flight plan of an aircraft that includes determining which vertical flight plan rules of a plurality of vertical flight rules that have been loaded in a predictions processor are active by monitoring for criteria that are used to initiate or terminate one or more of the vertical flight plan rules. Aircraft state is predicted at waypoints along a lateral flight path in view of active vertical flight plan rules, and the predicted aircraft state is updated within an integrated flight plan database that stores prediction performance data associated with the aircraft's flight.

    摘要翻译： 一种用于对垂直飞行计划进行性能预测的方法。 系统对飞行器的垂直飞行计划执行性能预测，其包括通过监视用于启动的标准来确定已经加载在预测处理器中的多个垂直飞行规则的哪些垂直飞行计划规则是活动的 终止一个或多个垂直飞行计划规则。 考虑到主动垂直飞行计划规则，沿着侧向飞行路径的航路点预测飞行器状态，并且在集成的飞行计划数据库内更新预测的飞行器状态，该飞行器状态存储与飞行器的飞行相关联的预测演奏数据。

    Filter assembly for cleaning cooling air for engines
    9.
    发明授权
    Filter assembly for cleaning cooling air for engines 失效
    用于清洁发动机冷却空气的过滤器组件

    公开(公告)号：US6162269A

    公开(公告)日：2000-12-19

    申请号：US299320

    申请日：1999-04-26

    申请人： Roy E. Greenlees ,  Richard Snyder ,  Kenneth S. Schultz ,  R. Ryan Greenlees

    发明人： Roy E. Greenlees ,  Richard Snyder ,  Kenneth S. Schultz ,  R. Ryan Greenlees

    IPC分类号： F01P11/12 ,  F02B77/00

    CPC分类号： F01P11/12 ,  Y10S55/28

    摘要： An engine filter assembly for cleaning cooling air for an internal-combustion engine for use in high-debris environment such as in roofing-removing machines includes a filter housing attached to the machine at a remote position. The filter housing houses a two-stage air filter that consists of a cylindrical-shaped filter element with an outer pre-filter covering. Both the carburetor air inlet and a fan housing leading to the cooling fan on the engine are connected to the filter housing by tubing. A shield protects the engine from direct contact with loose or air-borne materials during the operation of the machine. A thermal sensing device reads the temperature of the engine and automatically shuts down the engine if the temperature rises beyond specification, reducing the chance of engine failure.

    摘要翻译： 一种用于清洁用于高碎片环境的内燃机的冷却空气的发动机过滤器组件，例如在屋顶除尘机中包括在远程位置附接到机器的过滤器壳体。 过滤器壳体容纳两级空气过滤器，其由具有外部预过滤器覆盖物的圆柱形过滤元件组成。 化油器空气入口和通向发动机上的冷却风扇的风扇壳都通过管道连接到过滤器壳体。 屏蔽罩可保护发动机在机器运行过程中与松散或空气传播的材料直接接触。 如果温度升高超过规格，热感测装置读取发动机的温度并自动关闭发动机，减少发动机故障的机会。