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    Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
    3.
    发明授权
    Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin 有权
    通过施用人绒毛膜促性腺激素衍生物治疗和预防HIV感染

    公开(公告)号：US06699656B2

    公开(公告)日：2004-03-02

    申请号：US10050875

    申请日：2001-11-20

    申请人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    发明人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    IPC分类号： C12Q170

    CPC分类号： C07K14/59 ,  A61K38/00 ,  Y10S435/974

    摘要： The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.

    摘要翻译： 本发明涉及β-hCG，特别是具有41-54,45-54,47-53,45-57和45-58位氨基酸序列的β-hCG蛋白及其类似物和衍生物。 本发明还涉及通过施用本发明的治疗化合物治疗和预防HIV感染的方法。 这些治疗化合物包括hCG，β-hCG和β-hCG肽，hCG，β-hCG和β-hCG肽的类似物和衍生物，以及编码hCG，β-hCG和β-hCG肽的核酸。 在优选的实施方案中，将Aβ-hCG肽，特别是氨基酸47-53,45-57或45-58的β-hCG肽施用于受试者，以治疗或预防该受试者的HIV感染。 本发明还提供了用于筛选用于治疗或预防HIV感染的活性的hCG制剂的方法。 还提供药物组合物和治疗剂的施用方法。

    Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection
    4.
    发明授权
    Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection 失效
    巨噬细胞来源的趋化因子（MDC）作为用于治疗和预防慢病毒感染的抗病毒剂

    公开(公告)号：US06548631B1

    公开(公告)日：2003-04-15

    申请号：US08931764

    申请日：1997-09-16

    申请人： Anthony L. DeVico ,  Ranajit Pal ,  Robert C. Gallo ,  Phillip D. Markham ,  Alfredo Garzino-Demo

    发明人： Anthony L. DeVico ,  Ranajit Pal ,  Robert C. Gallo ,  Phillip D. Markham ,  Alfredo Garzino-Demo

    IPC分类号： C07K700

    CPC分类号： C07K14/523 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.

    摘要翻译： 本发明涉及巨噬细胞来源的趋化因子（MDC）的治疗组合物以及使用MDC蛋白质，核酸和/或其衍生物或类似物治疗和预防慢病毒，特别是免疫缺陷病毒，特别是HIV的感染的方法。 本发明还涉及使用MDC作为预后指标的禽流感病毒感染特别是HIV感染的检测和预后的方法。 本发明还提供了MDC蛋白质，编码这种蛋白质的核酸，其具有不同于其他MDC分离物的氨基末端序列。 还提供了重组宿主细胞和生产方法。

    Nucleic acids encoding biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
    10.
    发明授权
    Nucleic acids encoding biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) 有权
    编码生物活性多肽的核酸衍生自命名为雌激素（MA）的新型早期妊娠因子

    公开(公告)号：US09175077B2

    公开(公告)日：2015-11-03

    申请号：US13159285

    申请日：2011-06-13

    申请人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    发明人： Robert C. Gallo ,  Joseph Bryant ,  Yanto Lunardi-Iskandar

    IPC分类号： C07H21/02 ,  A61K38/00 ,  A61K38/04 ,  C12N1/20 ,  C12N15/00 ,  C07K16/26 ,  C07K14/59 ,  A61K48/00

    CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K48/00 ,  C07K14/59 ,  C07K2319/00

    摘要： The invention relates to nucleotides encoding therapeutic polypeptides and fragments thereof isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.

    摘要翻译： 本发明涉及编码从人类早孕尿中发现的现在合成产生并命名为Maternin的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽及其片段的核苷酸。 治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。 治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。 本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。