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    Substituted organopolysiloxanes and use thereof
    2.
    发明授权
    Substituted organopolysiloxanes and use thereof 有权

    公开(公告)号：US09982095B2

    公开(公告)日：2018-05-29

    申请号：US11659329

    申请日：2005-07-26

    申请人： John Robert Howe Wilson ,  Alice Caroline Sullivan ,  Siud Pui Man

    发明人： John Robert Howe Wilson ,  Alice Caroline Sullivan ,  Siud Pui Man

    IPC分类号： C08G77/28 ,  C08G77/50

    CPC分类号： C08G77/28 ,  C08G77/50

    摘要： The invention relates to new compounds of Formula 1: wherein R, R1, are each independently hydrogen, a linear or branched C1-40 alkyl, C2-40-alkenyl or C2-40-alkynyl group, an aryl or C1-40-alkylaryl group; X is H, OH, O(Mn)1/n or R4 where M is a metal ion derived from a lanthanide, actinide, main group or transition metal and V is a substituted C1-40-alkyl, C2-40-alkenyl or C2-40-alkynyl group or an aryl group or C1-40-alkylaryl sulfide, sulfoxide, sulfone, amine or a polyalkyl amine or phosphine or other phosphorous containing group; R4 is a linear or branched C1-40 alkyl, C2-40-alkenyl or C2-40-alkynyl group, an aryl or C1-40-alkylaryl group; e is an integer from 0 to 2; f is an integer from 1 to 100; n is an integer from 1 to 4: the free valences of the silicate oxygen atoms are saturated by one or more of: silicon atoms of other groups of Formula 1, hydrogen, a linear or branched C1-12-alkyl group or by cross-linking bridge members or by polymer chains (R2)2Si(OR3)1O1/2 or (R2)2SiO2/2 or (R2)3SiO1/2 or R2qTi(OR3)mOk/2 or Al(OR3)3−pOp/2 or R2Al(OR3)2−rOr/2; where R3 is a linear or branched C1- 12-alkyl group; and R2 is a linear or branched C1-6-alkyl group; k is an integer from 1 to 4 and q is an integer from 0 to 3 and m is an integer from 0 to 3; such that m+k+q=4; p is an integer from 1 to 3; and r is an integer from 1 to 2: a, b, c and d are integers such that the ratio of a:b varies from 0.00001 to 100,000 and in the formula AaBbCcDd where A represents [O3/2SiCH2CH2S(O)e(CRR1)fS(O)eX], B represents [(O3/2SiCH2CH2S(O)e(CRR1)fS(O)eCH2CH2Si(O3/2)], C represents [O4/2Si] and D represents [O3/2SiV] both A and B are always present. The compounds are useful as scavengers for the removal of unwanted organic and inorganic compounds, for solid phase extraction, for solid phase synthesis, for catalysis, for metal ion abstraction and for the immobilisation of bio-molecules. In addition, the compounds have high chemical and thermal stability, fixed and rigid structures, are insoluble in organic solvents, high resistance to ageing, and can easily be purified and reused.

    MOTION COMPENSATING CATHETER DEVICE
    5.
    发明申请
    MOTION COMPENSATING CATHETER DEVICE 审中-公开
    运动补偿导管装置

    公开(公告)号：US20130190726A1

    公开(公告)日：2013-07-25

    申请号：US13643625

    申请日：2011-04-29

    申请人： Samuel Kesner ,  Robert Howe ,  Shelton Yuen ,  Pedro Del Nido ,  Douglas Perrin ,  Nikolay Vasilyev

    发明人： Samuel Kesner ,  Robert Howe ,  Shelton Yuen ,  Pedro Del Nido ,  Douglas Perrin ,  Nikolay Vasilyev

    IPC分类号： A61M25/01

    CPC分类号： A61M25/0116 ,  A61B8/0841 ,  A61B8/483 ,  A61B8/565 ,  A61B34/20 ,  A61M25/0045 ,  A61M25/0105 ,  A61M25/0113 ,  A61M25/0133 ,  A61M25/0147 ,  A61M2025/0046 ,  A61M2025/0166 ,  A61M2025/0681

    摘要： A catheter system allows for percutaneous intervention on the fast-moving structures inside the heart. The device consists of a steerable catheter sheath, an actuated, multi-degree of freedom moving catheter, and a catheter end effector, such as a fixation device. An actuator controls the motion of the catheter guide-wire in the catheter sheath to follow the motion of the target tissue. A control system controls the actuator and compensates for mechanical characteristics of the system including friction and backlash. A 3-D imaging system can be used to view the motion of the target tissue and the catheter end effector and produce 3-D imaging data. The 3-D imaging data can be used by the control system to track the target tissue and accurately position the end effector with respect to the moving target tissue allowing a clinician to repair the target tissue while it is moving. The system can be used to perform mitral valve annuloplasty wherein the actuated catheter compensates for the heart valve motion and an end effector fixation device is used to place fixation items, like anchors or staples, into the heart valve tissue to fix the annulus.

    摘要翻译： 导管系统允许对心脏内的快速移动结构进行经皮干预。 该装置由可导向的导管鞘，致动的多自由度移动导管和导管末端执行器（例如固定装置）组成。 执行器控制导管护套中导管导丝的运动，以跟随目标组织的运动。 控制系统控制致动器并补偿系统的机械特性，包括摩擦和齿隙。 3-D成像系统可用于观察目标组织和导管末端执行器的运动并产生3-D成像数据。 控制系统可以使用3-D成像数据来跟踪目标组织并相对于运动的目标组织精确地定位末端执行器，允许临床医生在移动时修复目标组织。 该系统可用于执行二尖瓣瓣膜成形术，其中致动的导管补偿心脏瓣膜运动，并且使用末端执行器固定装置将固定物品（如锚或钉）放置在心脏瓣膜组织中以固定环。

    FUNCTIONALISED MATERIALS AND USES THEREOF
    6.
    发明申请
    FUNCTIONALISED MATERIALS AND USES THEREOF 审中-公开
    功能材料及其用途

    公开(公告)号：US20100290962A1

    公开(公告)日：2010-11-18

    申请号：US12738743

    申请日：2008-10-20

    申请人： John Robert Howe Wilson ,  Nico Galaffu ,  Siud Pui Man ,  Robin Wilkes

    发明人： John Robert Howe Wilson ,  Nico Galaffu ,  Siud Pui Man ,  Robin Wilkes

    IPC分类号： C22B11/00 ,  B01J41/12 ,  C02F1/42 ,  C22B23/00

    CPC分类号： C07F7/21 ,  A61K47/24 ,  A61K47/34

    摘要： [(O3/2)SiCH2CH2SX]a[Si(O4/2)]b[WSi(O3/2)]c[VSi(O3/2)]d wherein X is selected from (CR1R2)eNR5CO NHR, (CR1R2)eNR5CSNHR, W when present is selected from (CR6R7)eZR, (CH2)3SR1(CH2)3NRR1, (CH2)eSR8, CH2CH2S (CR1R2)fNR5CONHR, CH2CH2S(CR1R2),NR5CSNHR, CH2CH2S(CH2)fOR; Z is O or S, R, R1-7 are independently selected from hydrogen, alkyl group, aryl group or alkylaryl group, R8 is selected from [CH2CH2NR1]PR and (CR1R2)mSR9 where R9 is hydrogen, C1-22-alkyl group, and V is a group which is optionally substituted and selected from a C1-22-alkyl group, C2-22-alkenyl group, a C2-22-alkynyl group or an aryl group. The compounds are useful as immobilisation materials for bio-molecules including enzymes, cation and anion exchangers, organic and inorganic compound scavengers, solid phase purification or extraction materials, removal and purification of biological compounds including endotoxins, anti-microbial agents, hydrophilicity modifiers, flame proofing agents, antistatic agents, coatings for biomedical devices, water repellent films and coatings, solid phase synthesis materials and chromatography materials.

    摘要翻译： [（O3 / 2）SiCH2CH2SX] a [Si（O4 / 2）] b [WSi（O3 / 2）] c [VSi（O3 / 2）] d其中X选自（CR1R2）eNR5CO NHR，（CR1R2） 当存在时，eNR5CSNHR，W选自（CR6R7）eZR，（CH2）3SR1（CH2）3NRR1，（CH2）eSR8，CH2CH2S（CR1R2）fNR5CONHR，CH2CH2S（CR1R2），NR5CSNHR，CH2CH2S（CH2）fOR; Z为O或S，R 1，R 7为独立地选自氢，烷基，芳基或烷基芳基，R 8选自[CH 2 CH 2 NR1] PR和（CR 1 R 2）m S R 9，其中R 9为氢， 并且V是任选被取代并选自C 1-22烷基，C 2-20 - 烯基，C 2--22 - 炔基或芳基的基团。 该化合物可用作包括酶，阳离子和阴离子交换剂，有机和无机化合物清除剂，固相纯化或提取物质在内的生物分子的固定物质，除去和纯化包括内毒素，抗微生物剂，亲水性改性剂，火焰 防静电剂，生物医学装置用涂料，防水膜和涂料，固相合成材料和色谱材料。

    WORK PLACE AND STORAGE APPARATUS
    7.
    发明申请
    WORK PLACE AND STORAGE APPARATUS 有权
    工作地点和存储设备

    公开(公告)号：US20100194063A1

    公开(公告)日：2010-08-05

    申请号：US12457068

    申请日：2009-06-01

    申请人： WILLIAM HAND ,  ROBERT HOWE

    发明人： WILLIAM HAND ,  ROBERT HOWE

    IPC分类号： B62B3/02

    CPC分类号： B25H1/04 ,  B25H3/02 ,  B62B1/20 ,  B62B1/204 ,  B62B2205/32

    摘要： A storage and work place apparatus used in conjunction with a wheelbarrow or similar item. The apparatus includes a housing having a bottom portion and a side portion extending outwardly to form an open chamber the bottom portion is intended to a lie atop a wheelbarrow a cover is used in conjunction with the open chamber and is hingedly or slidingly attached to the housing in order to extend laterally from the housing. At least a first leg attainably connects to the housing and extends outwardly to contact a ground surface adjacent the wheel barrow. At least a second leg is rotatable attached to the cover and also extends outwardly therefrom to support the cover above the ground surface when the leg contacts the ground surface.

    摘要翻译： 与独轮车或类似物品一起使用的储存和工作场所装置。 该装置包括具有底部部分和向外延伸以形成开口腔室的侧部分的壳体，该底部部分旨在使其与开放室结合使用，并且铰接地或滑动地附接到壳体 以便从壳体横向延伸。 至少第一腿可以连接到壳体并且向外延伸以接触与手推车相邻的地面。 至少第二条腿可旋转地附接到盖并且当腿部接触地面时也从其向外延伸以支撑覆盖在地面上方的盖。

    Organopolysiloxanes containing phosphonic groups, method for the production and use thereof
    8.
    发明授权
    Organopolysiloxanes containing phosphonic groups, method for the production and use thereof 有权
    含有膦酸基的有机聚硅氧烷，其制备方法及其应用

    公开(公告)号：US07728159B2

    公开(公告)日：2010-06-01

    申请号：US11455545

    申请日：2006-06-19

    申请人： Alice Caroline Sullivan ,  John Robert Howe Wilson

    发明人： Alice Caroline Sullivan ,  John Robert Howe Wilson

    IPC分类号： C07F7/26

    CPC分类号： C07F9/4012 ,  B01J39/19 ,  C07C41/56 ,  C07C45/515 ,  C07C45/52 ,  C07C45/72 ,  C07C45/74 ,  C07C51/29 ,  C07C67/03 ,  C07C67/08 ,  C07D301/12 ,  C07D303/04 ,  C08G77/30 ,  C07C49/78 ,  C07C49/04 ,  C07C49/796 ,  C07C63/06 ,  C07C63/10 ,  C07C69/58 ,  C07C43/307

    摘要： The invention relates to new compounds of the formula, wherein R and R1 are each independently hydrogen, a linear or branched C1-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl or C1-40 alkylaryl group or an optionally complex metal ion Mn+/n wherein n is an integer from 1 to 8; the free valences of the silicate oxygen atoms are saturated by one or more of: silicon atoms of other groups of the formula, hydrogen, a linear or branched C1-12 alkyl group or by cross-linking bridge members R3qM1(OR2)mOk/2 or Al(OR2)3-pOp/2 or R3 Al(OR−)2-1 O1/2; wherein M1 is Si or Ti; R2 is linear or branched C1-12 alkyl group; and R3 is alinear or branched C1-6 alkyl group; k is an integer from 1 to 4 and q and m are integers from 0 to 2; such that M+k+q=4; and p is an integer from 1 to 3; and r is an integer from 1 to 2; or other known oxo metal bridging systems; x, y and z are integers such that the radio of x:y+z, varies from 0.00001 to 100,000 with the fragments [O3/2SiCH(CH2PO(OR)(OR1))CH2CH2SiO3/2]x and [O3/2SiCH2CH2PO(OR)(OR1)]y always present whilst the integer z varies from 0 to 200y. The compounds are useful as catalysts for a wide variety of reactions and have the advantages that they can be prepared in a one-pot reaction and functional group losding can be tailored to be at a required level. In addition, the compounds have high chemical and thermal stability, fixed and rigid structures, are insoluble in organic solvents, high resistance to ageing, and can easily be purified and reused.

    摘要翻译： 本发明涉及新的下式化合物，其中R 1和R 2各自独立地为氢，直链或支链C 1-20烷基，C 2-40链烯基或C 2-40炔基，芳基或C 1-4烷基芳基或任选地 复合金属离子Mn + / n，其中n为1至8的整数; 硅酸盐氧原子的自由价饱和的一个或多个：下式的其他基团的硅原子：氢，直链或支链的C 1-12烷基，或通过桥连构件R3qM1（OR2）mOk / 2 或Al（OR2）3-pOp / 2或R3Al（OR-）2-1O1 / 2; 其中M1是Si或Ti; R2是直链或支链C1-12烷基; 并且R 3是亚胺基或支链C 1-6烷基; k是1至4的整数，q和m是0至2的整数; 使得M + k + q = 4; 并且p是1至3的整数; 并且r是1至2的整数; 或其它已知的氧代金属桥接体系; 片段[O3 / 2SiCH（CH2PO（OR）（OR1））CH2CH2SiO3 / 2] x和[O3 / 2SiCH2CH2PO（...）的x：y + z的放射线从0.00001到100,000变化， OR）（OR1）] y总是存在，而整数z从0到200y变化。 该化合物可用作多种反应的催化剂，并且具有可以在一锅反应中制备的优点，并且官能团可以定制为所需的水平。 此外，化合物具有高的化学和热稳定性，固定和刚性结构，不溶于有机溶剂，耐老化，易于纯化和再利用。

    Robust Compliant Adaptive Grasper and Method of Manufacturing Same
    9.
    发明申请
    Robust Compliant Adaptive Grasper and Method of Manufacturing Same 有权
    强大的自适应Grasper和制造方法相同

    公开(公告)号：US20090302626A1

    公开(公告)日：2009-12-10

    申请号：US12447939

    申请日：2007-11-05

    申请人： Aaron Dollar ,  Robert Howe

    发明人： Aaron Dollar ,  Robert Howe

    IPC分类号： B25J15/00

    CPC分类号： B25J9/104 ,  B25J9/0015 ,  B25J15/12

    摘要： A mechanical grasping system that is both simple to fabricate and operate and robust. A multi-fingered hand may be driven by a single actuator, yet can grasp objects spanning a wide range of size, shape, and mass. The hand may be constructed using polymer-based Shape Deposition Manufacturing, with joints formed by elastomeric flexures and actuator and sensor components embedded in tough rigid polymers. The passively compliant, adaptive hand has superior robustness properties, able to withstand large impacts without damage and capable of grasping objects in the presence of large positioning errors, appropriate for use in unstructured and/or human environments.

    摘要翻译： 一种机械抓握系统，其制造和操作都很简单，坚固耐用。 多指手可以由单个执行器驱动，但可以抓住广泛尺寸，形状和质量的物体。 可以使用基于聚合物的形状沉积制造来构建手，其中由弹性体弯曲形成的接头和致动器以及传感器部件嵌入坚固的刚性聚合物中。 被动适应的自适应手具有优异的鲁棒性，能够承受大的冲击而不会损坏，并能够在存在大的定位误差的情况下抓住物体，适用于非结构化和/或人类环境。

    Phosphate flame retardant polymers
    10.
    发明授权
    Phosphate flame retardant polymers 失效
    磷酸酯阻燃聚合物

    公开(公告)号：US06815476B1

    公开(公告)日：2004-11-09

    申请号：US08841028

    申请日：1997-04-29

    申请人： Qamar Bhatia ,  Robert Howe

    发明人： Qamar Bhatia ,  Robert Howe

    IPC分类号： C08K553

    CPC分类号： C08K5/523 ,  C08L71/123 ,  C08L71/12 ,  C08L85/02 ,  C08L2666/04

    摘要： A flame retardant moldable thermoplastic resin composition consisting of a thermoplastic resin and a flame retardant consisting of a combination of a low molecular weight phosphate having a molecular weight of about 500 to about 2000 and a high molecular weight phosphate having a molecular weight of about 2300 to about 11,000 and to articles molded therewith. The composition has a high heat deflection temperature, good impact resistance, excellent flame retardancy and good flow for easier processing.

    摘要翻译： 一种由热塑性树脂和阻燃剂组成的阻燃可成型热塑性树脂组合物，该阻燃剂由分子量为约500至约2000的低分子量磷酸盐和分子量约2300至高分子量磷酸盐的组合组成， 约11,000件，以及与其成型的制品。 该组合物具有高的热变形温度，良好的耐冲击性，优异的阻燃性和良好的流动性以便加工。