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    Assay of blood or other biologic samples for target analytes
    1.
    发明授权
    Assay of blood or other biologic samples for target analytes 失效
    测定目标分析物的血液或其他生物样品

    公开(公告)号：US5635362A

    公开(公告)日：1997-06-03

    申请号：US247336

    申请日：1994-05-23

    Applicant: Robert A. Levine ,  Stephen C. Wardlaw ,  Rodolfo R. Rodriguez ,  Adrien P. Malick ,  Alvydas J. Ozinskas

    Inventor： Robert A. Levine ,  Stephen C. Wardlaw ,  Rodolfo R. Rodriguez ,  Adrien P. Malick ,  Alvydas J. Ozinskas

    IPC: G01N33/543 ,  B01L3/14 ,  G01N33/49 ,  G01N33/537 ,  G01N33/569 ,  G01N33/58 ,  G01N33/558

    CPC classification number: B01L3/5021 ,  G01N33/491 ,  G01N33/5375 ,  G01N33/56972 ,  G01N33/585 ,  Y10S435/81 ,  Y10S435/967 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/824 ,  Y10S436/829 ,  Y10T436/111666

    Abstract: A patient's health may be diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more bodies or groups of bodies such as floats, inserts, liposomes, or plastic beads of different densities. Each density-defined body carries analyte-capture binding materials such as antigens or antibodies, which are specific to an epitope, or other specific high affinity binding site on a target analyte which target analyte may be in the blood or other sample being tested; and the level of which analyte is indicative of the patient's health. At least one labeled binding material which is also specific to an epitope, or other specific high affinity binding site on the target analyte is added to the sample so as to form labeled binding material/analyte/body complexes in the sample. Upon centrifugation, the complexes will settle out in different areas in the tube according to the respective density of the body or bodies; and the degree of label emission of the complex layers can enable qualitative and/or quantitative analyses of the sample to be made. Unbound labeled binding materials will be separated from the complexed layers by the washing action of ascending or descending components of the sample during the centrifugation step. Unbound labeled binding material will thus not interfere with the analysis.

    Abstract translation: 可以通过将透明管中的血液样品离心来诊断患者的健康，该管包含一个或多个不同密度的浮体，插入物，脂质体或塑料珠的主体或组。 每个密度定义的身体携带分析物 - 捕获结合材料，例如抗原或抗体，其对靶分析物是特异性的，或靶分析物上的其它特异性高亲和力结合位点，其目标分析物可能在待测试的血液或其他样品中; 并且其分析物的水平表示患者的健康。 将至少一种对靶分析物上的表位或其他特异性高亲和力结合位点特异性的标记结合物质加入到样品中，以便在样品中形成标记的结合材料/分析物/身体复合物。 离心后，复合物将根据身体或身体的相应密度沉淀在管中的不同区域; 并且复合层的标签发射程度可以使得要进行样品的定性和/或定量分析。 通过在离心步骤期间样品的上升或下降组分的洗涤作用，未结合的标记结合材料将从复合层分离。 因此，未结合的标签结合材料不会影响分析。

    Fluid transfer mechanism
    3.
    发明授权
    Fluid transfer mechanism 失效
    流体输送机构

    公开(公告)号：US4276260A

    公开(公告)日：1981-06-30

    申请号：US115691

    申请日：1980-01-28

    Applicant: Vladimir J. Drbal ,  Guenter Ginsberg ,  Bruce J. Hodgins ,  John A. Richardson ,  Ted W. Britton ,  Richard M. Grimm ,  Ernesto Bello ,  Rodolfo R. Rodriguez ,  Ivan K. Saltz

    Inventor： Vladimir J. Drbal ,  Guenter Ginsberg ,  Bruce J. Hodgins ,  John A. Richardson ,  Ted W. Britton ,  Richard M. Grimm ,  Ernesto Bello ,  Rodolfo R. Rodriguez ,  Ivan K. Saltz

    IPC: B01F11/00 ,  G01N35/10 ,  G01N1/14

    CPC classification number: G01N35/1009 ,  B01F11/0082 ,  G01N2035/1025 ,  G01N2035/1086 ,  G01N35/1004

    Abstract: A fluid transfer mechanism for rapidly and accurately picking up or aspirating a fluid quantity or aliquot in one position, moving it to a second position and dispensing the aspirated aliquot. The mechanism includes an arm mounted on a high helix shaft on one end and driven up and down the shaft by a first motor and rotated around the shaft by a second motor. The arm includes at a second end a fluid transfer probe which is moved into and out of the fluids to aspirate and dispense the fluids in precise angular locations. The arm may be accelerated and deaccelerated as it is rotated to avoid vibrations and spilling of the fluid from the probe. The probe may include a level sensing structure for sensing when the probe has contacted a fluid surface. The probe also may be coupled to an oscillator to oscillate the probe in a vessel into which the fluid has been dispensed to mix the fluids therein.

    Abstract translation: 流体转移机构，用于快速且准确地将流体量或等分试样拾取或吸入一个位置，将其移动到第二位置并分配吸出的等分试样。 该机构包括臂，其一端安装在高螺旋轴上，并通过第一马达上下驱动轴，并通过第二马达围绕轴旋转。 臂在第二端包括流体转移探针，其被移入和流出流体以在精确的角度位置吸入和分配流体。 手臂可以在旋转时加速和减速，以避免来自探头的流体的振动和溢出。 探针可以包括用于感测探头何时接触流体表面的液位感测结构。 探针还可以耦合到振荡器以将探针摆动在已经分配流体的容器中以将流体混合在其中。

    MICROFLUIDIC CHAMBER ASSEMBLY FOR MASTITIS ASSAY
    4.
    发明申请
    MICROFLUIDIC CHAMBER ASSEMBLY FOR MASTITIS ASSAY 审中-公开
    用于MASTITIS测定的MICROFLUIDIC CHAMBER ASSEMBLY

    公开(公告)号：US20090233329A1

    公开(公告)日：2009-09-17

    申请号：US12294037

    申请日：2007-03-26

    Applicant: Rodolfo R. Rodriguez ,  Charles F. Galanaugh

    Inventor： Rodolfo R. Rodriguez ,  Charles F. Galanaugh

    IPC: C12Q1/06 ,  C12M1/34

    CPC classification number: G01N33/04 ,  B01L3/5027 ,  G01N1/2813 ,  G01N15/1463 ,  G01N15/1484 ,  G01N2015/008

    Abstract: The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like.

    Abstract translation: 本发明涉及一种用于从哺乳动物体液例如牛奶中检测乳腺炎或其它疾病的装置和方法。 该装置和方法涉及一种楔形微流体室，其用于使用最少量的流体并且能够使用该装置观察单层中的白细胞以用于疾病检测，细胞计数等。

    Fluid transfer mechanism
    7.
    发明授权
    Fluid transfer mechanism 失效
    流体输送机构

    公开(公告)号：US4341736A

    公开(公告)日：1982-07-27

    申请号：US248276

    申请日：1981-03-27

    Applicant: Vladimir J. Drbal ,  Guenter Ginsberg ,  Bruce J. Hodgins ,  John A. Richardson ,  Ted W. Britton ,  Richard M. Grimm ,  Ernesto Bello ,  Rodolfo R. Rodriguez ,  Ivan K. Saltz

    Inventor： Vladimir J. Drbal ,  Guenter Ginsberg ,  Bruce J. Hodgins ,  John A. Richardson ,  Ted W. Britton ,  Richard M. Grimm ,  Ernesto Bello ,  Rodolfo R. Rodriguez ,  Ivan K. Saltz

    IPC: B01F11/00 ,  G01N35/10 ,  G01N1/12 ,  G01N1/14

    CPC classification number: G01N35/1009 ,  B01F11/0082 ,  G01N2035/1025 ,  G01N2035/1086 ,  G01N35/1004

    Abstract: A fluid transfer mechanism for rapidly and accurately picking up or aspirating a fluid quantity or aliquot in one position, moving it to a second position and dispensing the aspirated aliquot. The mechanism includes an arm mounted on a high helix shaft on one end and driven up and down the shaft by a first motor and rotated around the shaft by a second motor. The arm includes at a second end a fluid transfer probe which is moved into and out of the fluids to aspirate and dispense the fluids in precise angular locations. The arm may be accelerated and deaccelerated as it is rotated to avoid vibrations and spilling of the fluid from the probe. The probe may include a level sensing structure for sensing when the probe has contacted a fluid surface. The probe also may be coupled to an oscillator to oscillate the probe in a vessel into which the fluid has been dispensed to mix the fluids therein.

    Abstract translation: 流体转移机构，用于快速且准确地将流体量或等分试样拾取或吸入一个位置，将其移动到第二位置并分配吸出的等分试样。 该机构包括臂，其一端安装在高螺旋轴上，并通过第一马达上下驱动轴，并通过第二马达围绕轴旋转。 臂在第二端包括流体转移探针，其被移入和流出流体以在精确的角度位置吸入和分配流体。 手臂可以在旋转时加速和减速，以避免来自探头的流体的振动和溢出。 探针可以包括用于感测探头何时接触流体表面的液位感测结构。 探针还可以耦合到振荡器以将探针摆动在已经分配流体的容器中以将流体混合在其中。

    Nephelometer having means semiautomatically cancelling components from scattering by particles smaller or larger than those of interest
    8.
    发明授权
    Nephelometer having means semiautomatically cancelling components from scattering by particles smaller or larger than those of interest 失效
    浊度计具有半自动消除部件不被感兴趣的粒子小于或大于粒子散射的装置

    公开(公告)号：US3967901A

    公开(公告)日：1976-07-06

    申请号：US600593

    申请日：1975-07-31

    Applicant: Rodolfo R. Rodriguez

    Inventor： Rodolfo R. Rodriguez

    IPC: G01N21/51 ,  G01N21/00

    CPC classification number: G01N21/51 ,  Y10S436/805

    Abstract: An improved nephelometer for immunochemical complex assay measures forward light scatter in samples. The angle of forward scatter, about 30.degree., is small enough to result in a large amount of forward scatter from the immunochemical complex particles which are to be assayed, whose size is of the order of the wave length of the light used in the optical system. Forward scattering from smaller particles, such as from molecules of buffer, antibody and serum, is constant during the course of a test, and is compensated for by the use of subtraction circuits which are readily and semiautomatically adjusted to subtract proper values, in accordance with the readings taken on standard or "blank" samples of buffer, antibody and serum. Forward scattering from large particles, such as dust, is variable, and results in fluctuating signals, which are electrically processed to ignore the spurious peaks. The results of a test are displayed on a digital read out meter.Also described is a method of and protocol for immunochemical assay, whereby the amount of antigen originally present in a sample is determined by adding a known amount of antibody, and by assaying the "blank" component ingredients and the resulting mixture.

    Abstract translation: 用于免疫化学复合物测定的改进的浊度计测量样品中的向前光散射。 约30°的前向散射角度足够小，导致要测定的免疫化学复合物颗粒的大量前向散射，其尺寸为光学中使用的光的波长的数量级 系统。 来自较小颗粒（例如来自缓冲液，抗体和血清的分子）的正向散射在测试过程中是恒定的，并且通过使用容易和半自动调整以减去适当值的减法电路进行补偿，以根据 在缓冲液，抗体和血清的标准或“空白”样品上读取的读数。 来自大颗粒（例如灰尘）的正向散射是可变的，并且导致波动的信号，其被电处理以忽略杂散峰。 测试结果显示在数字读出仪表上。

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